Receptor
PDB id Resolution Class Description Source Keywords
4TU8 1.92 Å NON-ENZYME: OTHER STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA HOMO SAPIENS RNA SPLICING FACTOR RNA RECOGNITION MOTIF RNA BINDING PROTBINDING PROTEIN-DNA COMPLEX
Ref.: STRUCTURE-GUIDED U2AF65 VARIANT IMPROVES RECOGNITIO SPLICING OF A DEFECTIVE PRE-MRNA. PROC.NATL.ACAD.SCI.USA V. 111 17420 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DIO B:401;
B:402;
B:403;
B:404;
A:401;
A:402;
B:405;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
none;
 submit data
88.105 C4 H8 O2 C1COC...
DU DU DU DU BRU DA DU E:1;
P:1;
 Valid;
Valid;
 none;
none;
 submit data
2065.1 n/a BrC=1...
GOL A:403;
 Invalid;
 none;
 submit data
92.094 C3 H8 O3 C(C(C...
EDO A:405;
B:410;
B:407;
B:409;
A:407;
A:404;
B:408;
A:406;
A:408;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
none;
none;
none;
 submit data
62.068 C2 H6 O2 C(CO)...
SO4 B:411;
A:409;
A:410;
 Invalid;
Invalid;
Invalid;
 none;
none;
none;
 submit data
96.063 O4 S [O-]S...
CPQ B:406;
 Invalid;
 none;
 submit data
862.056 C42 H75 N3 O15 C[C@H...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4TU8 1.92 Å NON-ENZYME: OTHER STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA HOMO SAPIENS RNA SPLICING FACTOR RNA RECOGNITION MOTIF RNA BINDING PROTBINDING PROTEIN-DNA COMPLEX
Ref.: STRUCTURE-GUIDED U2AF65 VARIANT IMPROVES RECOGNITIO SPLICING OF A DEFECTIVE PRE-MRNA. PROC.NATL.ACAD.SCI.USA V. 111 17420 2014
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4TU9 - DU DU DU DU BRU DG DU n/a n/a
2 4TU8 - DU DU DU DU BRU DA DU n/a n/a
3 4TU7 - DU DU DU DU BRU DU DU n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4TU9 - DU DU DU DU BRU DG DU n/a n/a
2 4TU8 - DU DU DU DU BRU DA DU n/a n/a
3 4TU7 - DU DU DU DU BRU DU DU n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4TU9 - DU DU DU DU BRU DG DU n/a n/a
2 4TU8 - DU DU DU DU BRU DA DU n/a n/a
3 4TU7 - DU DU DU DU BRU DU DU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: DU DU DU DU BRU DA DU ; Similar ligands found: 19
No: Ligand ECFP6 Tc MDL keys Tc
1 DU DU DU DU BRU DA DU 1 1
2 DU DU DU DU BRU DU DU 0.733871 0.888889
3 DU DU DU DU BRU DG DU 0.671329 0.896552
4 ADS THS THS THS 0.564626 0.863636
5 3PD UM3 0.527397 0.83908
6 139 0.486667 0.870588
7 PUA 0.471338 0.858824
8 DT MA7 DT 0.454545 0.840909
9 CPA 0.447368 0.892857
10 PAX 0.441718 0.872093
11 4TA 0.43038 0.894118
12 BRU 0.410853 0.831325
13 DT ME6 DT 0.410256 0.781609
14 DUT MG 0.407407 0.802469
15 DU 0.40625 0.771084
16 UMP 0.40625 0.771084
17 101 0.40458 0.807229
18 3DR DT DT DT DT DT 0.403974 0.788235
19 UMP AF3 PO4 0.40146 0.788235
Similar Ligands (3D)
Ligand no: 1; Ligand: DU DU DU DU BRU DA DU ; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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