Receptor
PDB id Resolution Class Description Source Keywords
5D6Y 2.29 Å EC: 1.14.11.- CRYSTAL STRUCTURE OF DOUBLE TUDOR DOMAIN OF HUMAN LYSINE DEM KDM4A COMPLEXED WITH HISTONE H3K23ME3 HOMO SAPIENS DOUBLE TUDOR DOMAIN READER DOMAIN STRUCTURAL GENOMICS PSIPROTEIN STRUCTURE INITIATIVE ENZYME DISCOVERY FOR NATURAL BIOSYNTHESIS NATPRO OXIDOREDUCTASE
Ref.: READER DOMAIN SPECIFICITY AND LYSINE DEMETHYLASE-4 FUNCTION. NAT COMMUN V. 7 13387 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLN LEU ALA THR M3L ALA ALA ARG LYS SER D:20;
C:20;
A:19;
B:19;
 Valid;
Valid;
Valid;
Valid;
 none;
none;
none;
none;
 Kd = 2.2 uM
n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5D6Y 2.29 Å EC: 1.14.11.- CRYSTAL STRUCTURE OF DOUBLE TUDOR DOMAIN OF HUMAN LYSINE DEM KDM4A COMPLEXED WITH HISTONE H3K23ME3 HOMO SAPIENS DOUBLE TUDOR DOMAIN READER DOMAIN STRUCTURAL GENOMICS PSIPROTEIN STRUCTURE INITIATIVE ENZYME DISCOVERY FOR NATURAL BIOSYNTHESIS NATPRO OXIDOREDUCTASE
Ref.: READER DOMAIN SPECIFICITY AND LYSINE DEMETHYLASE-4 FUNCTION. NAT COMMUN V. 7 13387 2016
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 43 families.
1 5D6Y Kd = 2.2 uM GLN LEU ALA THR M3L ALA ALA ARG LYS SER n/a n/a
2 5VAR Kd = 81.7 uM 92Y C16 H23 N O CN(C)C[C@H....
3 2GFA Kd = 10.4 uM ALA ARG THR M3L GLN THR ALA ARG LYS SER n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 31 families.
1 5D6Y Kd = 2.2 uM GLN LEU ALA THR M3L ALA ALA ARG LYS SER n/a n/a
2 5VAR Kd = 81.7 uM 92Y C16 H23 N O CN(C)C[C@H....
3 2GFA Kd = 10.4 uM ALA ARG THR M3L GLN THR ALA ARG LYS SER n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 28 families.
1 5D6Y Kd = 2.2 uM GLN LEU ALA THR M3L ALA ALA ARG LYS SER n/a n/a
2 5VAR Kd = 81.7 uM 92Y C16 H23 N O CN(C)C[C@H....
3 2GFA Kd = 10.4 uM ALA ARG THR M3L GLN THR ALA ARG LYS SER n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLN LEU ALA THR M3L ALA ALA ARG LYS SER; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: GLN LEU ALA THR M3L ALA ALA ARG LYS SER; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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