Receptor
PDB id Resolution Class Description Source Keywords
4MDR 1.85 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ADAPTOR PROTEIN COMPLEX 4 (AP-4) MU4 SU TERMINAL DOMAIN D190A MUTANT, IN COMPLEX WITH A SORTING PEPT HE AMYLOID PRECURSOR PROTEIN (APP) HOMO SAPIENS IMMUNOGLOBULIN-LIKE BETA-SANDWICH ADAPTOR PROTEIN COMPLEX APPARATUS SORTING SIGNAL RECOGNITION ALZHEIMER-prime S DISEASEPRECURSOR PROTEIN PROTEIN TRANSPORT-PROTEIN BINDING COMPLE
Ref.: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF CARGO SITES ON THE MU 4-SUBUNIT OF ADAPTOR PROTEIN COMPLE PLOS ONE V. 9 88147 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLU ASN PRO THR TYR LYS PHE PHE GLU GLN B:686;
 Valid;
 none;
 Kd = 40.6 uM
n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4MDR 1.85 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ADAPTOR PROTEIN COMPLEX 4 (AP-4) MU4 SU TERMINAL DOMAIN D190A MUTANT, IN COMPLEX WITH A SORTING PEPT HE AMYLOID PRECURSOR PROTEIN (APP) HOMO SAPIENS IMMUNOGLOBULIN-LIKE BETA-SANDWICH ADAPTOR PROTEIN COMPLEX APPARATUS SORTING SIGNAL RECOGNITION ALZHEIMER-prime S DISEASEPRECURSOR PROTEIN PROTEIN TRANSPORT-PROTEIN BINDING COMPLE
Ref.: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF CARGO SITES ON THE MU 4-SUBUNIT OF ADAPTOR PROTEIN COMPLE PLOS ONE V. 9 88147 2014
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4MDR Kd = 40.6 uM GLU ASN PRO THR TYR LYS PHE PHE GLU GLN n/a n/a
2 3L81 - THR TYR LYS PHE PHE GLU GLN n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4MDR Kd = 40.6 uM GLU ASN PRO THR TYR LYS PHE PHE GLU GLN n/a n/a
2 3L81 - THR TYR LYS PHE PHE GLU GLN n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4MDR Kd = 40.6 uM GLU ASN PRO THR TYR LYS PHE PHE GLU GLN n/a n/a
2 3L81 - THR TYR LYS PHE PHE GLU GLN n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLU ASN PRO THR TYR LYS PHE PHE GLU GLN; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: GLU ASN PRO THR TYR LYS PHE PHE GLU GLN; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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