Receptor
PDB id Resolution Class Description Source Keywords
4J82 1.46 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/INSIG-2 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DOMAIN DILYSINE MOTIF ER RETRIEVAL VESICLETRAFFICKING PROTEIN TRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS SER HIS GLN GLU D:1;
C:1;
 Valid;
Valid;
 none;
none;
 submit data
627.656 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J73 1.44 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/P25 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DILYSINE MOTIF ER RETRIEVAL SIGNAL COATOMERECOGNITION PROTEIN TRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Members (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
70% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
11 4J8B - LEU LYS THR LYS LEU LEU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: LYS SER HIS GLN GLU; Similar ligands found: 57
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS SER HIS GLN GLU 1 1
2 LYS HIS LYS 0.640449 0.884615
3 GLU LYS VAL HIS VAL GLN 0.601852 0.854545
4 PHE ASN GLU LEU SER HIS LEU 0.537736 0.875
5 ALA SER ASN GLU HIS MET GLU THR MET 0.525 0.819672
6 GLN GLY HIS GLY GLU 0.514563 0.867925
7 HIS SER LYS LYS LYS CYS ASP GLU LEU 0.512397 0.896552
8 LYS GLN LYS 0.505618 0.711538
9 SER ILE ILE GLN PHE GLU HIS LEU 0.504 0.847458
10 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.496403 0.822581
11 LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.492537 0.774194
12 LYS PRO HIS SER ASP 0.491667 0.866667
13 GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 0.488372 0.734375
14 SER HIS PHE ASN GLU TYR GLU 0.484375 0.847458
15 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.48062 0.79661
16 PHE SER GLN HIS LYS THR SER TPO ILE 0.478873 0.75
17 LYS GLU LYS 0.477778 0.711538
18 LYS SER LYS 0.477273 0.788462
19 ILE LEU MET GLU HIS ILE HIS LYS LEU 0.476562 0.758065
20 SER ASN TRP SER HIS PRO GLN PHE GLU LYS 0.470199 0.825397
21 LYS SER LEU LEU GLN GLN LEU LEU THR GLU 0.461538 0.724138
22 HIS LYS LEU VAL GLN LEU LEU THR THR THR 0.459677 0.87931
23 LYS GLY GLY ALA ALY ARG HIS ARG 0.458647 0.746032
24 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 0.453901 0.746032
25 SER HIS VAL ALA VAL GLU ASN ALA LEU 0.448819 0.859649
26 ALA LYS PHE ARG HIS ASP 0.448 0.8
27 GLU GLN TYR LYS PHE TYR SER VAL 0.44 0.737705
28 HIS LYS ILE LEU HIS ARG LEU LEU GLN ASP 0.439716 0.761905
29 ILE GLU GLU ALA LEU GLN ILE ILE HIS SER 0.439394 0.842105
30 ACE SER HIS VAL ALA VAL GLU ASN ALA LEU 0.4375 0.844828
31 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.437037 0.69697
32 ALA HIS HIS 0.43617 0.740741
33 THR ASP HIS GLY ALA GLU 0.435897 0.844828
34 GLY SER SER HIS HIS HIS HIS HIS 0.432692 0.872727
35 ARG ARG GLU VAL HIS THR TYR TYR 0.431655 0.746269
36 VAL LEU HIS ASP ASP LEU LEU GLU ALA 0.431034 0.754386
37 TYR GLN SER LYS LEU 0.429825 0.733333
38 LYS ARG ARG ARG HIS PRO SER GLY 0.426471 0.784615
39 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.42446 0.686567
40 VAL VAL SER HIS PHE ASN ASP 0.424 0.827586
41 THR SER ARG HIS LYS ALY LEU MET ALA 0.41844 0.75
42 GLY ALA ARG ALA HIS SER SER 0.418033 0.836066
43 GLU ALA ASP LYS TRP GLN SER 0.41791 0.859649
44 ALA LYS GLU LYS SER ASP 0.417476 0.777778
45 GLU GLN ASP LYS TRP ALA SER 0.414815 0.859649
46 SER HIS LYS ILE ASP ASN LEU ASP 0.414815 0.896552
47 GLY SER HIS LEU GLU VAL GLN GLY TYR TRP 0.414013 0.796875
48 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.412587 0.720588
49 GLU LEU ASP HIS TRP ALA SER 0.408759 0.8
50 LYS ARG ARG ARG HIS PRO SER 0.407407 0.738462
51 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.405405 0.671429
52 GLY LYS ILE SER LYS HIS TRP THR GLY ILE 0.405229 0.83871
53 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.404255 0.723077
54 GLN ALA SER GLN GLU VAL LYS ASN TRP 0.402778 0.864407
55 PHE SER HIS PRO GLN ASN THR 0.401408 0.8125
56 LYS LEU VAL GLN LEU LEU THR THR THR 0.4 0.689655
57 LEU ALA SER LEU GLU SER GLN SER 0.4 0.684211
Similar Ligands (3D)
Ligand no: 1; Ligand: LYS SER HIS GLN GLU; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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