Receptor
PDB id Resolution Class Description Source Keywords
1N4Q 2.4 Å EC: 2.5.1.58 PROTEIN GERANYLGERANYLTRANSFERASE TYPE-I COMPLEXED WITH A GG AND A KKKSKTKCVIL PEPTIDE RATTUS NORVEGICUS PROTEIN GERANYLGERANYLTRANSFERASE TYPE-I GGTASE GERANYLGERPROTEIN PRENYLATION CAAX LIPID MODIFICATION RAP2B TRANS
Ref.: STRUCTURE OF MAMMALIAN PROTEIN GERANYLGERANYLTRANSF TYPE-I EMBO J. V. 22 5963 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL C:1301;
D:1306;
F:1309;
G:1311;
H:1312;
J:1315;
K:1317;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
none;
 submit data
35.453 Cl [Cl-]
GER R:1300;
 Part of Protein;
 none;
 submit data
274.484 C20 H34 CC=C(...
MGM B:1401;
D:1402;
F:1403;
H:1404;
J:1405;
L:1406;
 Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
 none;
none;
none;
none;
none;
none;
 submit data
453.447 C19 H37 N O7 P2 CC(=C...
ZN B:378;
D:378;
F:378;
H:378;
J:378;
L:378;
 Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
none;
none;
none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1N4Q 2.4 Å EC: 2.5.1.58 PROTEIN GERANYLGERANYLTRANSFERASE TYPE-I COMPLEXED WITH A GG AND A KKKSKTKCVIL PEPTIDE RATTUS NORVEGICUS PROTEIN GERANYLGERANYLTRANSFERASE TYPE-I GGTASE GERANYLGERPROTEIN PRENYLATION CAAX LIPID MODIFICATION RAP2B TRANS
Ref.: STRUCTURE OF MAMMALIAN PROTEIN GERANYLGERANYLTRANSF TYPE-I EMBO J. V. 22 5963 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1N4Q - MGM C19 H37 N O7 P2 CC(=CCC/C(....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1N4Q - MGM C19 H37 N O7 P2 CC(=CCC/C(....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1N4Q - MGM C19 H37 N O7 P2 CC(=CCC/C(....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: MGM; Similar ligands found: 26
No: Ligand ECFP6 Tc MDL keys Tc
1 MGM 1 1
2 VTP 0.5625 0.75
3 OTP 0.5625 0.75
4 FPP 0.5625 0.764706
5 ZTP 0.5625 0.75
6 GRG 0.5625 0.764706
7 ELR 0.557143 0.803922
8 ELU 0.557143 0.803922
9 3E9 0.542857 0.803922
10 FGG 0.528571 0.722222
11 2CF 0.514286 0.722222
12 FPF 0.514286 0.722222
13 GPP 0.5 0.745098
14 FFF 0.492958 0.722222
15 0K3 0.483871 0.692308
16 FJP 0.483871 0.705882
17 DSL 0.483871 0.692308
18 GGS 0.449275 0.685185
19 FPS 0.449275 0.685185
20 FDF 0.438356 0.735849
21 HZZ 0.435484 0.686275
22 DED 0.431034 0.862745
23 PS7 0.423529 0.709091
24 3AG 0.42029 0.846154
25 FPQ 0.407895 0.745455
26 FHP 0.402985 0.622642
Similar Ligands (3D)
Ligand no: 1; Ligand: MGM; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1N4Q; Ligand: MGM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1n4q.bio3) has 27 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1N4Q; Ligand: MGM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1n4q.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 1N4Q; Ligand: MGM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1n4q.bio5) has 27 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1N4Q; Ligand: MGM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1n4q.bio4) has 27 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1N4Q; Ligand: MGM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1n4q.bio2) has 27 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1N4Q; Ligand: MGM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 1n4q.bio6) has 26 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback