Receptor
PDB id Resolution Class Description Source Keywords
3L81 1.6 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ADAPTOR PROTEIN COMPLEX 4 (AP-4) MU4 SU TERMINAL DOMAIN, IN COMPLEX WITH A SORTING PEPTIDE FROM THEP RECURSOR PROTEIN (APP) HOMO SAPIENS IMMUNOGLOBULIN-LIKE BETA-SANDWICH COATED PIT GOLGI APPARATMEMBRANE PHOSPHOPROTEIN PROTEIN TRANSPORT TRANSPORT ALZDISEASE AMYLOID AMYLOIDOSIS TRANSPORT PROTEIN
Ref.: SORTING OF THE ALZHEIMER'S DISEASE AMYLOID PRECURSO MEDIATED BY THE AP-4 COMPLEX. DEV.CELL V. 18 425 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:1;
A:2;
A:3;
 Invalid;
Invalid;
Invalid;
 none;
none;
none;
 submit data
92.094 C3 H8 O3 C(C(C...
THR TYR LYS PHE PHE GLU GLN B:686;
 Valid;
 none;
 submit data
n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4MDR 1.85 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ADAPTOR PROTEIN COMPLEX 4 (AP-4) MU4 SU TERMINAL DOMAIN D190A MUTANT, IN COMPLEX WITH A SORTING PEPT HE AMYLOID PRECURSOR PROTEIN (APP) HOMO SAPIENS IMMUNOGLOBULIN-LIKE BETA-SANDWICH ADAPTOR PROTEIN COMPLEX APPARATUS SORTING SIGNAL RECOGNITION ALZHEIMER-prime S DISEASEPRECURSOR PROTEIN PROTEIN TRANSPORT-PROTEIN BINDING COMPLE
Ref.: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF CARGO SITES ON THE MU 4-SUBUNIT OF ADAPTOR PROTEIN COMPLE PLOS ONE V. 9 88147 2014
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4MDR Kd = 40.6 uM GLU ASN PRO THR TYR LYS PHE PHE GLU GLN n/a n/a
2 3L81 - THR TYR LYS PHE PHE GLU GLN n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4MDR Kd = 40.6 uM GLU ASN PRO THR TYR LYS PHE PHE GLU GLN n/a n/a
2 3L81 - THR TYR LYS PHE PHE GLU GLN n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4MDR Kd = 40.6 uM GLU ASN PRO THR TYR LYS PHE PHE GLU GLN n/a n/a
2 3L81 - THR TYR LYS PHE PHE GLU GLN n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: THR TYR LYS PHE PHE GLU GLN; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: THR TYR LYS PHE PHE GLU GLN; Similar ligands found: 1
No: Ligand Similarity coefficient
1 THR TYR LYS PHE PHE GLU GLN 1.0000
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
Feedback