Protein Class Information

4.1.1.23

Families belonging to this class:

90% Homology Family

Leader:	1DBT	CRYSTAL STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM BACILLUS SUBTILIS COMPLEXED WITH UMP

PDB id	Binding data	Representative ligand
1DBT	Ki = 0.46 mM	U5P

90% Homology Family

Leader:	1DQX	CRYSTAL STRUCTURE OF OROTIDINE 5'-PHOSPHATE DECARBOXYLASE COMPLEXED TO 6-HYDROXYURIDINE 5'-PHOSPHATE (BMP)

PDB id	Binding data	Representative ligand
1DQX	Ki = 9.0 pM	BMP
3GDL		UP6
3GDT		UP6

90% Homology Family

Leader:	1EIX	STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM E. COLI, CO-CRYSTALLISED WITH THE INHIBITOR BMP

PDB id	Binding data	Representative ligand
1EIX	Ki = 8.8 pM	BMQ

90% Homology Family

Leader:	1X1Z	OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE (ODCASE ) COMPLEXED (PRODUCED FROM 6-CYANOUMP)

PDB id	Binding data	Representative ligand
1X1Z	Ki = 8.8 pM	BMP
1DVJ	Ki = 0.51 mM	UP6
1KLY		UP6
1KLZ		U
1KM0		UP6
1KM1		UP6
1KM2		UP6
1KM3		UP6
1KM4		U
1KM5		UP6
1KM6		OMP
1LOL	Ki = 0.41 uM	XMP
1LOQ	Ki = 0.2 mM	U
1LOR	Ki = 8.8 pM	BMP
1LOS	Ki = 64.0 nM	UP6
1LP6		C5P
2ZZ1		BMP
2ZZ2		6CN
2ZZ5		6CN
2ZZ7		BMP
3G1A		UP6
3G1D		U
3G1F	Ki = 100.0 uM	2OM
3G1H		H2U
3G1V		5FU
3G1X		U
3G22		U
3G24		UP6
3LHT		BMQ
3LHU		BMQ
3LHV		BMQ
3LHW		BMQ
3LHY		BMQ
3LHZ		BMQ
3LI0		BMQ
3LI1		BMQ
3LLD		UP6
3LLF		UP6
3LTP		BMP
3LTS		BMP
3LTY		BMP
3LV5		BMP
3LV6		BMP
3M1Z		BMP
3NQC		BMP
3NQD		BMP
3NQE		BMP
3NQF		BMP
3NQG		BMP
3NQM		BMP
3PBU		UP6
3PBV		UP6
3PBW		UP6
3PBY		UP6
3PC0		UP6

90% Homology Family

Leader:	3MI2	CRYSTAL STRUCTURE OF HUMAN OROTIDINE-5'-MONOPHOSPHATE DECARB COMPLEXED WITH PYRAZOFURIN MONOPHOSPHATE

PDB id	Binding data	Representative ligand
3MI2	Ki = 1.7E-5 mM	PFU
2QCD		U5P
2QCF		5FU
2QCG		5BU
2QCH		UMP
2QCL		OMP
2QCM		JW5
3EWX		BMP
3EWY		U5P
3EWZ	ic50 = 79.0 uM	CNU
3EX1		6CN
3EX2	ic50 ~ 200.0 uM	6CN
3EX4		BMP
3L0K	ic50 = 24.0 uM	6AU
3L0N	ic50 = 1680.0 uM	S5P