CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND TOLRESTAT
PDB id Source Resolution
1ZUA 1.25 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
NAP Valid submit data   launch gocavviewer-lite   743.405
C21 H28 N7 O17 P3
 c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N
TOL Valid ic50 =  10.0 nM   launch gocavviewer-lite   357.347
C16 H14 F3 N O3 S
 CN(CC(=O)O)C(=S)c1cccc2c1ccc(c2C(F)(F)F)OC

STRUCTURAL BASIS FOR THE HIGH ALL-TRANS-RETINALDEHYDE REDUCTASE ACTIVITY OF THE TUMOR MARKER AKR1B10. PROC.NATL.ACAD.SCI.USA V. 104 20764 2007

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90% Homology Family

The Class containing this family consists of a total of 6 families.
Leader:    1ZUA
CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+
AND TOLRESTAT