CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
PDB id Source Resolution
1DRF HOMO SAPIENS 2.0 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
FOL Valid Kd =  0.111 uM   launch gocavviewer-lite   441.397
C19 H19 N7 O6
 c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
SO4 Invalid            

CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE. EUR.J.BIOCHEM. V. 174 377 1988

More Information
External References
PDB
Pubmed
Biounit Downloads
This PDB
This Family
This Class
Comma Separated Files
This PDB
This Family
This Class
Download BindingMOAD
90% Homology Family

The Class containing this family consists of a total of 22 families.
Leader:    1U72
UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE
RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG
VARIANT M OUSE AND HUMAN DIHYDRFOLATE REDUCTASE
TERNARY CRYSTAL CO MPLEXES WITH METHOTREXATE AND NADPH
PDB id Binding data Representative ligand
1U72 Kd = 0.0034 nM MTX
1BOZ ic50 = 8500.0 nM PRD
1DHF Kd = 0.111 uM FOL
1DLR Ki = 16.4 nM MXA
1DLS Ki = 10.9 nM MTX
1DRF Kd = 0.111 uM FOL
1HFP Ki = 1036.0 nM MOT
1HFQ Ki = 2.7 nM MOT
1HFR Ki = 790.0 nM MOT
1KMS   LIH
1KMV   LII
1MVS   DTM
1MVT   DTM
1OHJ   NDP
1OHK   NDP
1PD8   NDP
1PD9   CO4
1S3U   TQD
1S3V   TQD
1S3W   NAP
1U71   MXA
2C2S ic50 = 0.15 uM 34B
2C2T ic50 = 15.0 uM 39E
2DHF   DZF
3EIG Ki = 21.0 nM MTX
3F8Y Ki = 8.3 nM DH1
3F8Z Ki = 66.0 nM DH1
3F91   DH1
3FS6 Ki = 230.0 nM DH1
3GHC   NDP
3GHV   NDP
3GHW Kd = 0.02 uM GHW
3GI2   GHW
3GYF ic50 = 12.3 nM 51P
3N0H Ki = 617.0 nM TOP
3NTZ ic50 = 0.09 uM 3TZ
3NU0 ic50 = 0.1 uM 3TU
3NXX Ki = 11.0 uM D2D
3NXY   NDP
3NZD   D2Q
3S3V Ki = 593.0 nM TOP
3S7A   684