CRYSTAL STRUCTURE OF WILD-TYPE PFDHFR-TS COMPLEXED WITH NADP AND PYRIMETHAMINE
PDB id Source Resolution
3QGT 2.3 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
NDP Valid submit data   launch gocavviewer-lite   745.421
C21 H30 N7 O17 P3
 c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CCC(=C5)C(=O)N)O)O)O)OP(=O)(O)O)N
UMP Valid submit data   launch gocavviewer-lite   308.182
C9 H13 N2 O8 P
 C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)(O)O)O
CP6 Valid submit data   launch gocavviewer-lite   248.711
C12 H13 Cl N4
 CCc1c(c(nc(n1)N)N)c2ccc(cc2)Cl

TRYPANOSOMAL DIHYDROFOLATE REDUCTASE REVEALS NATURA ANTIFOLATE RESISTANCE ACS CHEM.BIOL. 2011

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90% Homology Family

The Class containing this family consists of a total of 22 families.
Leader:    3QGT
CRYSTAL STRUCTURE OF WILD-TYPE PFDHFR-TS COMPLEXED
WITH NADP AND PYRIMETHAMINE
PDB id Binding data Representative ligand
3QGT   NDP
3QG2   NDP