HORSE LIVER ALCOHOL DEHYDROGENASE HIS51GLN/LYS228ARG MUTANT COMPLEXED WITH NAD+ AND 2,4-DIFLUOROBENZYL ALCOHOL
PDB id Source Resolution
1QV6 EQUUS CABALLUS 1.8 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
NAD Valid submit data   launch gocavviewer-lite   663.425
C21 H27 N7 O14 P2
 c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
24B Valid submit data   launch gocavviewer-lite   144.119
C7 H6 F2 O
 c1cc(c(cc1F)F)CO
MPD Invalid            

PARTICIPATION OF HISTIDINE-51 IN CATALYSIS BY HORSE LIVER ALCOHOL DEHYDROGENASE. BIOCHEMISTRY V. 43 3014 2004

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90% Homology Family

The Class containing this family consists of a total of 14 families.
Leader:    2JHF
STRUCTURAL EVIDENCE FOR A LIGAND COORDINATION
SWITCH IN LIVER ALCOHOL DEHYDROGENASE
PDB id Binding data Representative ligand
2JHF Kd = 5.0 nM NAD
1A71   NAD
1AXE   NAD
1AXG   ETF
1BTO Ki = 0.31 uM SSB
1EE2   NAD
1HET   NAD
1HEU   NAD
1HF3   NAD
1HLD Ki = 3.0 uM PFB
1JU9 Ki = 1640.0 uM NAD
1LDE   FPI
1LDY   CXF
1MG0   DFB
1MGO Ki = 51.0 uM PFB
1N8K   NAJ-PZO
1N92 Ki = 0.02 uM NAJ-PYZ
1P1R Ki = 15.0 uM NMH
1QLH   NAD
1QV6   NAD
1QV7   NAD
2JHG   NAD-IBO
2OHX   NAD
2OXI   NAD
3BTO Ki = 0.72 uM SSB
3OQ6   NAJ