N-(PYRIDIN-2-YL) ARYLSULFONAMIDE INHIBITORS OF 11B- HYDROXYSTEROID DEHYDROGENASE TYPE 1: DISCOVERY OF PF-915275
PDB id Source Resolution
3G49 2.5 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
3G4 Valid Ki =  287.0 nM   launch gocavviewer-lite   395.904
C18 H22 Cl N3 O3 S
 CCN(CC)C(=O)Cc1cccc(n1)NS(=O)(=O)c2cccc(c2C)Cl
NAP Valid submit data   launch gocavviewer-lite   743.405
C21 H28 N7 O17 P3
 c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N

N-(PYRIDIN-2-YL) ARYLSULFONAMIDE INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE TYPE 1: DISCOVERY OF PF-915275 BIOORG.MED.CHEM.LETT. V. 19 3493 2009

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90% Homology Family

The Class containing this family consists of a total of 3 families.
Leader:    1XSE
CRYSTAL STRUCTURE OF GUINEA PIG 11BETA-HYDROXYSTEROID
DEHYDR TYPE 1
PDB id Binding data Representative ligand
1XSE   NDP
3DWF   NAP
3G49 Ki = 287.0 nM 3G4
3LZ6   A0D