ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR
PDB id Source Resolution
1AH3 2.3 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
NAP Valid submit data   launch gocavviewer-lite   743.405
C21 H28 N7 O17 P3
 c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N
TOL Valid submit data   launch gocavviewer-lite   357.347
C16 H14 F3 N O3 S
 CN(CC(=O)O)C(=S)c1cccc2c1ccc(c2C(F)(F)F)OC

A 'SPECIFICITY' POCKET INFERRED FROM THE CRYSTAL STRUCTURES OF THE COMPLEXES OF ALDOSE REDUCTASE WITH THE PHARMACEUTICALLY IMPORTANT INHIBITORS TOLRESTAT AND SORBINIL. STRUCTURE V. 5 601 1997

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90% Homology Family

The Class containing this family consists of a total of 5 families.
Leader:    1EKO
PIG ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
PDB id Binding data Representative ligand
1EKO   NAP
1AH0   NAP
1AH3   NAP
1AH4   NAP