HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE CORE AND TIF2 NRBOX2 PEPTIDE
PDB id Source Resolution
1GWQ HOMO SAPIENS 2.45 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
ZTW Valid submit data   launch gocavviewer-lite   242.293
C14 H10 O2 S
 c1cc(ccc1c2cc3ccc(cc3s2)O)O
LYS ILE LEU HIS ARG LEU LEU GLN ASP Valid Kd =  76.0 nM   launch gocavviewer-lite n/a  n/a n/a n/a

INTERACTION OF TRANSCRIPTIONAL INTERMEDIARY FACTOR 2 NUCLEAR RECEPTOR BOX PEPTIDES WITH THE COACTIVATOR BINDING SITE OF ESTROGEN RECEPTOR ALPHA. J.BIOL.CHEM. V. 277 21862 2002

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90% Homology Family

The Class containing this family consists of a total of 161 families.
Leader:    2QE4
ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN
IN COMPLEX WITH A BENZOPYRAN AGONIST
PDB id Binding data Representative ligand
2QE4 Ki = 0.28 nM JJ3
1GWQ Kd = 76.0 nM LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP
1GWR Kd = 250.0 nM ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP
1QKT Kd = 0.92 nM EST
1SJ0 ic50 = 0.8 nM E4D
1UOM ic50 = 19.0 nM PTI
1XP1 ic50 = 0.5 nM AIH
1XP6 ic50 = 0.4 nM AIU
1XP9 ic50 = 1.3 nM AIJ
1XPC ic50 = 1.7 nM AIT
1XQC ic50 = 63.0 nM AEJ
1YIM ic50 = 1.5 nM CM4
1YIN ic50 = 1.4 nM CM3
2AYR Ki = 0.52 nM L4G
2BJ4   OHT
2IOG ic50 = 8.0 nM IOG
2IOK ic50 = 1.0 nM IOK
2OUZ   C3D
2POG Ki = 0.29 nM WST
2Q70 Ki = 8.3 nM DC8
2QXS   RAL
2R6W Ki = 0.44 nM LLB
2R6Y Ki = 0.32 nM LLC
3DT3   369
3ERT   OHT
3OS8   KN0
3OS9   KN1
3OSA   KN3