HUMAN PPRR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST TIPP703
PDB id Source Resolution
2ZNO 2.4 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
S44 Valid submit data Fewer atoms than expected were found for ligand in PDB. % Diff = 0.108108  launch gocavviewer-lite   503.672
C32 H41 N O4
 CCCOc1ccc(cc1CNC(=O)c2ccc(cc2)C34CC5CC(C3)CC(C5)C4)C[C@H](CC)C(=O)O

ADAPTABILITY AND SELECTIVITY OF HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) PAN AGONISTS REVEALED FROM CRYSTAL STRUCTURES ACTA CRYSTALLOGR.,SECT.D V. 65 786 2009

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90% Homology Family

The Class containing this family consists of a total of 161 families.
Leader:    2P4Y
CRYSTAL STRUCTURE OF HUMAN PPAR-GAMMA-LIGAND
BINDING DOMAIN COMPLEXED WITH AN INDOLE-BASED MODULATOR
PDB id Binding data Representative ligand
2P4Y Ki = 0.0010 uM C03
1I7I   AZ2
1KNU   YPA
1ZEO ic50 = 0.21 uM C01
2ATH ic50 = 0.152 uM 3EA
2F4B ic50 = 50.0 nM EHA
2G0H ic50 = 22.7 nM SP3
2GTK ic50 = 0.251 uM 208
2HWQ   DRY
2HWR   DRD
2I4J   DRJ
2I4P   DRH
2I4Z   DRH
2POB   GW4
2Q59   240
2Q5P   241
2Q5S   NZA
2Q61   SF1
2Q6R   SF2
2Q6S   PLB
2Q8S ic50 = 0.185 uM L92
2ZK6   C08
2ZNO   S44
2ZVT   PTG
3ADS Kd = 9.73 uM IMN
3ADV Kd = 933.0 uM SRO
3ADW Kd = 72.8 uM MYI
3ADX   IMN
3AN3   M7S
3AN4   M7R
3BC5 ic50 = 0.0050 uM ZAA
3CS8   BRL
3D6D   LRG
3ET0   GLC
3FUR Ki = 10.0 nM Z12
3GBK   2PQ
3HOD   ZZH
3IA6 ic50 = 0.0030 uM UNT
3PBA   ZXG
3TY0 ic50 = 83.1 nM 082
3U9Q Ki = 41.7 uM DKA