CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DIB 4,6-DICARBOXYLIC ACID
PDB id Source Resolution
1DVU HOMO SAPIENS 1.9 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Weight
(Da)		 Formula SMILES
DBF Valid submit data More atoms than expected were found for ligand in PDB. % Diff = 2.0  launch gocavviewer-lite   256.21
C14 H8 O5
 c1cc2c3cccc(c3oc2c(c1)C(=O)O)C(=O)O

RATIONAL DESIGN OF POTENT HUMAN TRANSTHYRETIN AMYLO DISEASE INHIBITORS. NAT.STRUCT.BIOL. V. 7 312 2000

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90% Homology Family

The Class containing this family consists of a total of 146 families.
Leader:    2G5U
HUMAN TRANSTHYRETIN (TTR) COMPLEXED WITH HYDROXYLATED
POLYCH BIPHENYL-4,4'-DIHYDROXY-3,3',5,5'-TETRACHLOROBIPHENYL
PDB id Binding data Representative ligand
2G5U Kd = 3.2 nM NEW
1BM7 Kd = 30.0 nM FLF
1DVS   STL
1DVT   FLP
1DVU   DBF
1DVX   DIF
1DVY   BPD
1DVZ Kd = 78.0 nM OFL
1E4H Kd = 3.9 nM PBR
1E5A Kd = 23.0 nM TBP
1ETA   T44
1ETB   T44
1F86   T44
1THA   T33
1THC   FL9
1TLM   MIL
1TT6   DES
1TYR Kd = 0.1 uM REA
1TZ8   DES
1U21 Kd = 5.0 nM P2C
1Y1D   FHI
1Z7J   T4A
2B14   DNF
2B15   DNF
2B16   DNF
2B77   3CA
2B9A   FBC
2F7I   26C
2F8I   205
2FBR   44C
2FLM   6CA
2G9K   NE1
2GAB   NE2
2QGC   MR4
2QGD   MR5
2QGE   MR6
2ROX   T44
2ROY   P28
3B56   DIU
3CFN Kd = 4.3 uM 2AN
3CFQ   DIF
3CFT Kd = 64.0 uM 5NS
3CN0   LJ1
3CN1   LJ2
3CN2   LJ3
3CN3   LJ4
3CN4   LJ5
3D2T Kd = 1100.0 nM 1FL
3ESN   DZ1
3ESO   DZ2
3ESP   DZ3
3FC8 ic50 = 4.1 uM IFA
3FCB ic50 = 4.9 uM IFB
3GLZ   1BD
3GS0   6BD
3GS4   7BD
3GS7   8BD
3IMR   IW1
3IMS   IW2
3IMT   IW3
3IMU   IW4
3IMV   IW5
3IMW   IW6
3IPB ic50 = 0.2 uM JZD
3IPE ic50 = 0.15 uM JZE
3KGT Kd = 3.1 uM GEN
3KGU Kd = 1.2 uM GEN
3M1O   CJZ
3NEE   B72
3NEO   G24
3NES   B72
3NEX   G24
3NG5   KDH