SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN C WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-V( KFPPYVNC-NH2)
PDB id Source Resolution
1TZE HOMO SAPIENS 2.1 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
LYS PRO PHE PTR VAL ASN VAL NH2 Valid ic50 =  148.0 nM   launch gocavviewer-lite n/a  n/a n/a n/a

STRUCTURAL BASIS FOR SPECIFICITY OF GRB2-SH2 REVEAL NOVEL LIGAND BINDING MODE. NAT.STRUCT.BIOL. V. 3 586 1996

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90% Homology Family

The Class containing this family consists of a total of 172 families.
Leader:    1JYQ
XRAY STRUCTURE OF GRB2 SH2 DOMAIN COMPLEXED WITH
A HIGHLY AF PHOSPHO PEPTIDE
PDB id Binding data Representative ligand
1JYQ Kd = 2.5 nM MAZ-PTR-PTM-ASN
1JYR Kd = 18.0 nM ALA-PRO-SER-PTR-VAL-ASN-VAL-GLN-ASN
1TZE ic50 = 148.0 nM LYS-PRO-PHE-PTR-VAL-ASN-VAL-NH2
1ZFP ic50 = 26.0 nM BE2-GLU-PTR-ILE-ASN-GLN-NH2
2AOA   S1S
2AOB   S1S
3MXC Kd = 286.0 nM GLN-ASN-GLY-PTR-GLU-ASN-PRO-THR-TYR
3MXY Kd = 384.0 nM GLN-ASN-GLY-PTR-VAL-ASN-PRO-THR-TYR
3N7Y Ka = 1.0E7 M^-1 PTR-VAL-ASN-VAL-011