X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH BR-HIBO AT 1.65 A RESOLUTION
PDB id Source Resolution
1M5C RATTUS NORVEGICUS 1.65 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
BRH Valid ic50 =  0.5 uM   launch gocavviewer-lite   251.035
C6 H7 Br N2 O4
 C(c1c(c(no1)O)Br)C(C(=O)O)N

STRUCTURAL BASIS FOR AMPA RECEPTOR ACTIVATION AND LIGAND SELECTIVITY: CRYSTAL STRUCTURES OF FIVE AGONIST COMPLEXES WITH THE GLUR2 LIGAND-BINDING CORE J.MOL.BIOL. V. 322 93 2002

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90% Homology Family

The Class containing this family consists of a total of 172 families.
Leader:    1M5B
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE
(S1S2J) IN WITH 2-ME-TET-AMPA AT 1.85 A RESOLUTION.
PDB id Binding data Representative ligand
1M5B ic50 = 9.7 nM BN1
1FTJ ic50 = 821.0 nM GLU
1FTK ic50 = 14.5 uM KAI
1FTL ic50 = 998.0 nM DNQ
1FTM Kd = 24.8 nM AMQ
1FW0   KAI
1GR2   KAI
1LB8   AMQ
1LB9   DNQ
1LBB   KAI
1LBC   CYZ
1M5C ic50 = 0.5 uM BRH
1M5D ic50 = 9.2 uM BRH
1M5E ic50 = 20.1 nM AM1
1M5F ic50 = 14.8 nM AM1
1MM6 ic50 = 20.0 nM QUS
1MM7 ic50 = 20.0 nM QUS
1MQD ic50 = 0.17 uM SHI
1MQG ic50 = 0.52 uM IWD
1MQH ic50 = 0.3 uM BWD
1MQI ic50 = 23.53 nM FWD
1MQJ ic50 = 4.76 uM HWD
1MS7 ic50 = 0.17 uM SHI
1MXU ic50 = 4.0 uM BWD
1MY2   AMQ
1MY3   BWD
1MY4   IWD
1N0T ic50 = 12.2 uM AT1
1NNK ic50 = 3.5 uM CE2
1NNP   CE2
1P1N Kd = 0.16 uM KAI
1P1O Kd = 1.74 uM QUS
1P1Q Kd = 12.8 uM AMQ
1P1U   AMQ
1P1W   AMQ
1SYH Ki = 393.0 nM CPW
1SYI Ki = 3330.0 nM CPW
1WVJ Ki = 185.0 nM IBC
1XHY Ki = 624.0 nM KAI
2AIX   U1K
2AL4   QUS
2AL5   FWD
2ANJ   KAI
2GFE   GLU
2I3V   GLU
2I3W   GLU
2P2A Ki = 0.75 uM MP9
2XHD   7T9
2XX7   1ND
2XX8   1NE
2XX9   1NF
2XXH   1NG
2XXI   JAC
3B6Q   GLU
3B6T   QUS
3B6W   GLU
3B7D   CNI
3BBR   BHY
3BFT Ki = 323.0 nM S2P
3BFU Ki = 531.0 nM R2P
3BKI ic50 = 7.6 uM FQX
3DLN   GLU
3DP4 Kd = 43.0 nM AMQ
3DP6   GLU
3EN3   KAI
3FAS Ki = 171.0 nM GLU
3FAT Ki = 22.8 nM AMQ
3H03 ic50 = 135.0 uM UBP
3H6T   CYZ
3H6U   NS3
3H6V   NS6
3H6W   NS7
3IJO   B4D
3IK6   GLU
3IL1   B5D
3ILT   B7D
3ILU   HFZ
3KFM   KAI
3KGC   ZK1
3LSF   PZI
3LSL   PZI
3LSW   GLU
3LSX   PZI
3M3F   P99
3M3K   GLU
3M3L   P99
3O28   O28
3O29   O29
3O2A   O30
3O6G   O27
3O6H   O25
3O6I   O26
3PD8 Ki = 108.0 nM HA7
3PD9 Ki = 494.0 nM HA5
3PMV   557
3PMW   G69
3PMX   808
3R7X ic50 = 0.082 uM QSN
3RN8   RN8
3RNN   RNN
3RT8   CWD
3RTF   CWD
3RTW   NWD
3T93   GLU
3T96   IWD
3T9H   KAI
3T9U   CNI
3T9V   CNI
3T9X   GLU
3TDJ   GLU
3TKD   CYZ
3TZA ic50 = 3.4 uM TZG