CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOI (DXR) COMPLEXED WITH PYRIDIN-2-YLMETHYLPHOSPHONIC ACID
PDB id Source Resolution
3ANL 2.1 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
NDP Valid submit data   launch gocavviewer-lite   745.421
C21 H30 N7 O17 P3
 c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CCC(=C5)C(=O)N)O)O)O)OP(=O)(O)O)N
SYC Valid ic50 =  4.6 uM   launch gocavviewer-lite   173.106
C6 H8 N O3 P
 c1ccnc(c1)CP(=O)(O)O

STRUCTURES OF 1-DEOXY-D-XYLULOSE-5-PHOSPHATE REDUCTOISOMERASE/LIPOPHILIC PHOSPHONATE COMPLEXES ACS MED CHEM LETT V. 2 165 2011

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90% Homology Family

The Class containing this family consists of a total of 3 families.
Leader:    1Q0H
CRYSTAL STRUCTURE OF SELENOMETHIONINE-LABELLED
DXR IN COMPLE FOSMIDOMYCIN
PDB id Binding data Representative ligand
1Q0H Ki ~ 21.0 nM FOM
1JVS   NDP
1ONP   FOM
1Q0Q   NDP
1T1R ic50 = 4.0 uM IMB
1T1S ic50 = 7.0 uM CBQ
2EGH Ki = 38.0 nM FOM
3ANL ic50 = 4.6 uM SYC
3ANM ic50 = 0.84 uM SYD
3ANN ic50 = 15.9 uM SYE
3R0I ic50 = 0.12 uM C0K