THYMIDYLATE SYNTHASE R178T MUTANT
PDB id Source Resolution
1BO8 LACTOBACILLUS CASEI 2.4 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
U Valid submit data   launch gocavviewer-lite   324.181
C9 H13 N2 O9 P
 C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O

ENERGETIC CONTRIBUTIONS OF FOUR ARGININES TO PHOSPHATE-BINDING IN THYMIDYLATE SYNTHASE ARE MORE ADDITIVE AND DEPEND ON OPTIMIZATION OF "EFFECTIVE C BALANCE". BIOCHEMISTRY V. 39 1011 2000

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90% Homology Family

The Class containing this family consists of a total of 6 families.
Leader:    2G86
L. CASEI THYMIDYLATE SYNTHASE Y261F IN COMPLEX
WITH SUBSTRAT
PDB id Binding data Representative ligand
2G86 Kd = 0.44 uM UMP
1BO7   U
1BO8   U
1BP0 Kd = 4.0 uM UMP
1BP6   UMP
1BPJ   UMP
1JMF Kd = 1.7 uM UMP
1JMG Kd = 0.85 uM UMP
1JMH   UMP
1JMI Kd = 0.87 uM UMP
1LCA   UMP
1LCB   TMP
1LCE   UMP
1NJA Kd = 0.49 uM DCM
1NJC Kd = 2.8 uM DCM
1NJD Kd = 2.7 uM UMP
1NJE Kd = 160.0 uM DCM
1TSL Ki = 0.7 uM A15
1TSX   UMP
1TSY Kd = 11.0 uM UMP
1TVU   UMP
1TVV   UMP
1TVW   UMP
1VZA   UMP
1VZB   UMP
1VZC   UFP
1VZD   UFP
1VZE   CB3
2G89   UMP
2G8A   UMP
2G8D   UMP