HUMAN FPPS COMPLEX WITH FBS_04 AND ZOLEDRONIC ACID/MG2+
PDB id Source Resolution
3N45 1.88 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
3N3 Valid submit data   launch gocavviewer-lite   297.305
C17 H15 N O4
 c1ccc(cc1)COC(=O)N2c3ccccc3C[C@H]2C(=O)O
ZOL Valid submit data   launch gocavviewer-lite   272.09
C5 H10 N2 O7 P2
 c1cn(cn1)CC(O)(P(=O)(O)O)P(=O)(O)O
PO4 Valid submit data   launch gocavviewer-lite   94.971
O4 P
 [O-]P(=O)([O-])[O-]

ALLOSTERIC NON-BISPHOSPHONATE FPPS INHIBITORS IDENT FRAGMENT-BASED DISCOVERY. NAT.CHEM.BIOL. V. 6 660 2010

More Information
External References
PDB
Pubmed
Biounit Downloads
This PDB
This Family
This Class
Comma Separated Files
This PDB
This Family
This Class
Download BindingMOAD
90% Homology Family

The Class containing this family consists of a total of 4 families.
Leader:    3N6K
HUMAN FPPS COMPLEX WITH NOV_823
PDB id Binding data Representative ligand
3N6K ic50 = 0.2 uM BFH
1YQ7   RIS
1YV5   RIS
1ZW5   IPR
2F8C   ZOL
2F92   AHD
2F94   BFQ
2F9K   ZOL
2OPM   NI9
3N1V ic50 > 500.0 uM 3N1
3N45   3N3
3N46   ZOL
3N49 ic50 = 7.0 uM 3N4
3N5H ic50 = 2.0 uM GO0
3N5J ic50 = 8.0 uM GO1