GLUTATHIONE S-TRANSFERASE P1-1
PDB id Source Resolution
19GS HOMO SAPIENS 1.9 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
BSP Valid submit data Fewer atoms than expected were found for ligand in PDB. % Diff = 0.777778  launch gocavviewer-lite   792.018
C20 H8 Br4 O10 S2
 c1cc(c(cc1C2(c3c(c(c(c(c3Br)Br)Br)Br)C(=O)O2)c4ccc(c(c4)S(=O)(=O)[O-])O)S(=O)(=O)[O-])O
GTT Valid submit data   launch gocavviewer-lite   308.331
C10 H18 N3 O6 S
 C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)[NH3+]
MES Invalid            

THE LIGANDIN (NON-SUBSTRATE) BINDING SITE OF HUMAN GLUTATHIONE TRANSFERASE IS LOCATED IN THE ELECTROPH BINDING SITE (H-SITE). J.MOL.BIOL. V. 291 913 1999

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90% Homology Family

The Class containing this family consists of a total of 44 families.
Leader:    3IE3
STRUCTURAL BASIS FOR THE BINDING OF THE ANTI-
CANCER COMPOUND NITRO-2,1,3-BENZOXADIAZOL-4-YLTHIO
)HEXANOL (NBDHEX) TO HUMAG LUTATHIONE S-TRANSFERASES
PDB id Binding data Representative ligand
3IE3 Kd = 0.21 uM N11
10GS Ki = 0.4 uM VWW
11GS Ki = 1.5 uM GTT-EAA
12GS   GLU-GT9-GLY
13GS Ki = 24.0 uM SAS
17GS   GTX
18GS   GDB
19GS   BSP
1AQV   ILG-PBB-GLY
1AQW   ILG-CYS-GLY
1AQX   ILG-TNB-GLY
1KBN   GTT
1LBK Kd = 668.0 uM GSH
1MD3   GSH
1MD4   GSH
1PGT   GTX
1PX6   GSH
1PX7   GSH
2A2R Ka = 3300.0 M^-1 GSN
2A2S Ka = 3300.0 M^-1 GSN
2GSS Ki = 11.5 uM EAA
2J9H Ki = 410.0 uM GTX
2PGT   GPR
3CSH   GTT
3CSI   GTT
3CSJ   CBL
3DD3   GTT
3DGQ ic50 = 12.0 uM EAA
3GSS Ki = 1.5 uM GTT-EAA
3GUS Kd = 0.9 uM N11
3HJO   EAA
3KM6   EAA
3PGT   GBX
4GSS   GTX
4PGT   GBX
5GSS   GTT
6GSS   GTT
7GSS   GTT
8GSS   GTT
9GSS   GTX