STRUCTURE OF THE XENOBIOTIC SUBSTRATE BINDING SITE OF A GLUT TRANSFERASE AS REVEALED BY X-RAY CRYSTALLOGRAPHIC ANALYSIS C OMPLEXES WITH THE DIASTEREOMERS OF 9-(S-GLUTATHIONYL)-10-H10 -DIHYDROPHENANTHRENE
PDB id Source Resolution
2GST 1.8 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
GPS Valid Ki =  0.85 uM   launch gocavviewer-lite   501.552
C24 H27 N3 O7 S
 c1ccc2c(c1)-c3ccccc3[C@@H]([C@H]2O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
SO4 Invalid            

STRUCTURE AND FUNCTION OF THE XENOBIOTIC SUBSTRATE SITE OF A GLUTATHIONE S-TRANSFERASE AS REVEALED BY CRYSTALLOGRAPHIC ANALYSIS OF PRODUCT COMPLEXES WITH DIASTEREOMERS OF 9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHR BIOCHEMISTRY

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90% Homology Family

The Class containing this family consists of a total of 44 families.
Leader:    3GST
STRUCTURE OF THE XENOBIOTIC SUBSTRATE BINDING
SITE OF A GLUTATHIONE S-TRANSFERASE AS REVEALED
BY X-RAY C RYSTALLOGRAPHIC ANALYSIS
OF PRODUCT COMPLEXES WITH THE DI ASTEREOMERS
OF 9-(S-GLUTATHIONYL)-10-HYDROXY-9, 10-
DIH YDROPHENANT
PDB id Binding data Representative ligand
3GST Ki = 0.19 uM GPR
1MTC   GPR
2GST Ki = 0.85 uM GPS
3FYG   GPR
4GST   GTD
5FWG   CYP
5GST   GDB
6GST   GTT
6GSU   GPS
6GSV   GPS
6GSW   GPS
6GSX   GPS
6GSY   GTT