E. COLI EPSP SYNTHASE (TIPS MUTATION) LIGANDED WITH S3P AND GLYPHOSATE
PDB id Source Resolution
3FK1 1.7 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
to launch)		 Chemaxon
Viewer		 Molecular
Weight
(Da)		 Formula SMILES
S3P Valid submit data   launch gocavviewer-lite   254.131
C7 H11 O8 P
 C1[C@H]([C@@H]([C@@H](C=C1C(=O)O)OP(=O)(O)O)O)O
FMT Invalid            
GPF Valid Ki =  2420.0 uM   launch gocavviewer-lite   169.073
C3 H8 N O5 P
 C(C(=O)O)NCP(=O)(O)O

STRUCTURAL BASIS OF GLYPHOSATE RESISTANCE RESULTING FROM THE DOUBLE MUTATION THR97 -> ILE AND PRO101 -> SER IN 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE FROM ESCHERICHIA COLI. J.BIOL.CHEM. V. 284 9854 2009

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90% Homology Family

The Class containing this family consists of a total of 3 families.
Leader:    2PQ9
E. COLI EPSPS LIGANDED WITH (R)-DIFLUOROMETHYL
TETRAHEDRAL R INTERMEDIATE ANALOG
PDB id Binding data Representative ligand
2PQ9 Ki = 7.8 nM GG9
1G6S   S3P
1G6T   S3P
1MI4   S3P
1Q36   SKP
1X8R Ki ~ 2.9 uM SC1
1X8T Ki ~ 24.0 nM RC1
2AA9   SKM
2AAY ic50 = 1.7 mM GPJ
2QFQ ic50 = 66.0 uM S3P
2QFS Ki = 5.5 uM S3P
2QFT Ki = 5.5 uM S3P
2QFU Ki = 66.0 uM S3P
3FJX   S3P
3FJZ Ki = 90.0 uM GPF
3FK0   S3P
3FK1 Ki = 2420.0 uM GPF