STRUCTURE OF FPT BOUND TO DATFP-DH-GPP
PDB id Source Resolution
3KSL 2.05 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
SZH Valid submit data More atoms than expected were found for ligand in PDB. % Diff = 2.0  launch gocavviewer-lite   472.288
C13 H25 F3 N2 O9 P2
 C[C@@H](CCC/C(=C/CO[P@@](=O)(O)OP(=O)(O)O)/C)COC(=O)C(C(F)(F)F)NN

SYNTHESIS, PROPERTIES, AND APPLICATIONS OF DIAZOTRIFLUROPROPANOYL-CONTAINING PHOTOACTIVE ANALOGS OF FARNESYL DIPHOSPHATE CONTAINING MODIFIED LINKAGES FOR ENHANCED STABILITY. CHEM.BIOL.DRUG DES. V. 75 51 2010

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90% Homology Family

The Class containing this family consists of a total of 2 families.
Leader:    1MZC
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE
WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 33A
PDB id Binding data Representative ligand
1MZC ic50 = 0.06 nM BNE
1D8D   FII
1JCQ   739
1JCR   CYS-VAL-PHE-MET
1JCS   THR-LYS-CYS-VAL-PHE-MET
1KZO Kd = 5.0 nM FPP
1LD7 ic50 = 1.1 nM U66
1LD8 ic50 = 3.5 nM U49
1O1R   GRG
1O1S Ki = 49.0 nM 1NH
1O1T   2NH
1O5M ic50 = 1.9 nM 336
1S63 Ki = 0.9 nM 778
1SA4   JAN
1TN6   FII
1TN7   LYS-LYS-SER-LYS-THR-LYS-CYS-VAL-ILE-PHE
1TN8   GLY-CYS-VAL-LEU-SER
2IEJ   FII
2ZIR ic50 = 6.4 nM NH7
3E30   ED4
3E32   ED2
3E33   ED7
3E34   ED1
3E37 ic50 = 4050.0 nM ED5
3KSL   SZH
3KSQ ic50 = 0.38 nM Z96
3PZ4 ic50 = 6.0 nM 3PZ