PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RA PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND S IMULTANEOUSLY
PDB id Source Resolution
1KZO RATTUS NORVEGICUS 2.2 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
(click picture
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
FPP Valid Kd =  5.0 nM   launch gocavviewer-lite   382.326
C15 H28 O7 P2
 CC(=CCC/C(=C/CC/C(=C/CO[P@@](=O)(O)OP(=O)(O)O)/C)/C)C
ACY Invalid            
FAR Invalid            

THE REACTION PATH OF PROTEIN FARNESYLTRANSFERASE AT RESOLUTION NATURE V. 419 645 2002

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90% Homology Family

The Class containing this family consists of a total of 2 families.
Leader:    1MZC
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE
WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 33A
PDB id Binding data Representative ligand
1MZC ic50 = 0.06 nM BNE
1D8D   FII
1JCQ   739
1JCR   CYS-VAL-PHE-MET
1JCS   THR-LYS-CYS-VAL-PHE-MET
1KZO Kd = 5.0 nM FPP
1LD7 ic50 = 1.1 nM U66
1LD8 ic50 = 3.5 nM U49
1O1R   GRG
1O1S Ki = 49.0 nM 1NH
1O1T   2NH
1O5M ic50 = 1.9 nM 336
1S63 Ki = 0.9 nM 778
1SA4   JAN
1TN6   FII
1TN7   LYS-LYS-SER-LYS-THR-LYS-CYS-VAL-ILE-PHE
1TN8   GLY-CYS-VAL-LEU-SER
2IEJ   FII
2ZIR ic50 = 6.4 nM NH7
3E30   ED4
3E32   ED2
3E33   ED7
3E34   ED1
3E37 ic50 = 4050.0 nM ED5
3KSL   SZH
3KSQ ic50 = 0.38 nM Z96
3PZ4 ic50 = 6.0 nM 3PZ