CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG) IN COMPL BMS-ANALOGUE 14
PDB id Source Resolution
3PZ3 2.0 angstroms
Ligand Information
Ligand Validity Binding
Data		 Ligand
Warnings		 Eolus Viewer
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Viewer		 Molecular
Weight
(Da)		 Formula SMILES
PZ3 Valid ic50 =  141.0 nM   launch gocavviewer-lite   745.843
C41 H39 N5 O7 S
 Cn1cncc1CN2C[C@H]([N@@](Cc3c2ccc(c3)c4ccc(o4)C=O)S(=O)(=O)c5ccc(cc5)OC)Cc6ccc(cc6)OC(=O)NCc7ccccc7

STRUCTURE-GUIDED DEVELOPMENT OF SELECTIVE RABGGTASE INHIBITORS. ANGEW.CHEM.INT.ED.ENGL. V. 50 4957 2011

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90% Homology Family

The Class containing this family consists of a total of 1 families.
Leader:    3DST
CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA
IG)IN COMPLEX WITH GERANYLGERANYL PYROPHOSPHATE
PDB id Binding data Representative ligand
3DST Kd = 0.83 nM GRG
3C72 ic50 = 22.7 uM CX1
3DSU Kd = 0.94 nM FPP
3DSV   GER
3DSW   GER
3DSX   GER
3HXB   BD5
3HXC   BD6
3HXE   BD8
3HXF   BD9
3PZ1 ic50 = 724.0 nM 3PZ
3PZ2 ic50 = 724.0 nM 3PZ
3PZ3 ic50 = 141.0 nM PZ3