Receptor
PDB id Resolution Class Description Source Keywords
1A28 1.8 Å NON-ENZYME: SIGNAL_HORMONE HORMONE-BOUND HUMAN PROGESTERONE RECEPTOR LIGAND-BINDING DOMAIN HOMO SAPIENS PROGESTERONE RECEPTOR STEROID RECEPTOR NUCLEAR RECEPTOR TRANSCRIPTION REGULATION
Ref.: AROMATIC BETA-AMINO-KETONE DERIVATIVES AS NOVEL SELECTIVE NON-STEROIDAL PROGESTERONE RECEPTOR AGONISTS. BIOORG MED CHEM V. 18 4255 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
STR A:1;
B:2;
Valid;
Valid;
none;
none;
Ki = 5.1 nM
314.462 C21 H30 O2 CC(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1SR7 1.46 Å NON-ENZYME: SIGNAL_HORMONE PROGESTERONE RECEPTOR HORMONE BINDING DOMAIN WITH BOUND MOME FUROATE HOMO SAPIENS PROGESTERONE RECEPTOR MOMETASONE PROGESTERONE NUCLEAR RECHORMONE RECEPTOR TRANSCRIPTION
Ref.: PROGESTERONE RECEPTOR LIGAND BINDING POCKET FLEXIBI CRYSTAL STRUCTURES OF THE NORETHINDRONE AND MOMETAS FUROATE COMPLEXES J.MED.CHEM. V. 47 3381 2004
Members (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 224 families.
1 3ZRA - ORB C18 H17 Cl F N3 O3 S Cc1c(c(on1....
2 1SQN Kd = 0.4 nM NDR C20 H26 O2 C[C@]12CC[....
3 3G8O ic50 = 125 nM 30X C15 H15 F6 N3 O C[C@@H](C(....
4 3ZRB - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
5 3KBA ic50 = 16 nM WOW C20 H22 Cl N3 O2 S Cc1ccccc1C....
6 4A2J - AS0 C28 H35 N O4 C[C@]12C[C....
7 2W8Y - NDR C20 H26 O2 C[C@]12CC[....
8 4APU - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
9 3HQ5 ic50 = 16 nM GKK C20 H19 Cl F3 N3 C[N@]1CC[C....
10 1A28 Ki = 5.1 nM STR C21 H30 O2 CC(=O)[C@H....
11 1ZUC ic50 = 1.7 nM T98 C16 H15 N3 O S CC1(c2cc(c....
12 3ZR7 - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
13 1SR7 Kd = 0.08 nM MOF C27 H30 Cl2 O6 C[C@@H]1C[....
14 3D90 - NOG C21 H28 O2 CC[C@]12CC....
70% Homology Family (76)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 172 families.
1 3RY9 - 1CA C21 H30 O3 C[C@]12CC[....
2 1I38 - DHT C19 H30 O2 C[C@]12CCC....
3 1XNN Ki = 0.5 nM HYQ C20 H18 N2 O4 c1ccc2c(c1....
4 2PIP - ICO C9 H7 N O2 c1ccc2c(c1....
5 2AMA - DHT C19 H30 O2 C[C@]12CCC....
6 1E3G - R18 C19 H24 O2 C[C@@]1(CC....
7 2AX9 Ki = 0.3 nM BHM C11 H10 Br F3 N2 O4 C[C@](CBr)....
8 2AMB - 17H C21 H28 O2 CC[C@@]1(C....
9 4OEA - DHT C19 H30 O2 C[C@]12CCC....
10 3B67 - B67 C17 H10 F8 N2 O5 C[C@](COc1....
11 3RLL - RLL C23 H16 F3 N3 O3 C[C@](COc1....
12 2PIU - DHT C19 H30 O2 C[C@]12CCC....
13 2AXA Ki = 6.1 nM FHM C17 H14 F4 N2 O5 C[C@](COc1....
14 2YLO - TES C19 H28 O2 C[C@]12CC[....
15 2PNU - ENM C27 H36 F2 O3 C[C@]12CCC....
16 4HLW - 17W C15 H14 N2 O S c1ccc(cc1)....
17 2PIQ - RB1 C16 H19 N5 O CC(C)(C)n1....
18 2HVC - LGD C14 H9 F9 N2 O c1cc2c(cc1....
19 2OZ7 - CA4 C24 H29 Cl O4 CC(=O)[C@]....
20 3B65 - 3B6 C18 H14 I N3 O3 C[C@](COc1....
21 2IHQ Ki = 3.2 nM LG7 C17 H13 N3 O3 c1ccc2c(c1....
22 3B68 - B68 C19 H18 F3 N3 O6 CC(=O)Nc1c....
23 3B5R - B5R C18 H13 Cl F4 N2 O3 C[C@](COc1....
24 2AX8 - FHM C17 H14 F4 N2 O5 C[C@](COc1....
25 2PIV - T3 C15 H12 I3 N O4 c1cc(c(cc1....
26 2PIX - FLF C14 H10 F3 N O2 c1ccc(c(c1....
27 2QPY - DHT C19 H30 O2 C[C@]12CCC....
28 2PIR - NK C7 H6 O2 c1ccc(c(c1....
29 2YHD Ki = 23 uM AV6 C17 H14 N2 O2 c1cc2cccc3....
30 1T7T - DHT C19 H30 O2 C[C@]12CCC....
31 1Z95 Kd = 0.76 nM 198 C18 H14 F4 N2 O4 S C[C@](CS(=....
32 3RLJ - RLJ C19 H14 F3 N3 O3 C[C@](COc1....
33 2AX6 - HFT C11 H11 F3 N2 O4 CC(C)(C(=O....
34 2PKL - DHT C19 H30 O2 C[C@]12CCC....
35 2AX7 - FHM C17 H14 F4 N2 O5 C[C@](COc1....
36 2PIO - DHT C19 H30 O2 C[C@]12CCC....
37 3ZQT - TES C19 H28 O2 C[C@]12CC[....
38 1GS4 - ZK5 C21 H29 F O5 C[C@]12CCC....
39 2AM9 - TES C19 H28 O2 C[C@]12CC[....
40 3B66 - B66 C18 H16 F3 N3 O5 C[C@](COc1....
41 1XQ3 - R18 C19 H24 O2 C[C@@]1(CC....
42 2PIT - DHT C19 H30 O2 C[C@]12CCC....
43 3G0W Ki = 0.3 nM LGB C15 H13 Cl F3 N3 O2 Cc1c(ccc(c....
44 4OJB - 198 C18 H14 F4 N2 O4 S C[C@](CS(=....
45 2YLQ - TES C19 H28 O2 C[C@]12CC[....
46 1I37 - DHT C19 H30 O2 C[C@]12CCC....
47 2YLP - TES C19 H28 O2 C[C@]12CC[....
48 3ZRA - ORB C18 H17 Cl F N3 O3 S Cc1c(c(on1....
49 1SQN Kd = 0.4 nM NDR C20 H26 O2 C[C@]12CC[....
50 3G8O ic50 = 125 nM 30X C15 H15 F6 N3 O C[C@@H](C(....
51 3ZRB - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
52 3KBA ic50 = 16 nM WOW C20 H22 Cl N3 O2 S Cc1ccccc1C....
53 4A2J - AS0 C28 H35 N O4 C[C@]12C[C....
54 2W8Y - NDR C20 H26 O2 C[C@]12CC[....
55 4APU - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
56 3HQ5 ic50 = 16 nM GKK C20 H19 Cl F3 N3 C[N@]1CC[C....
57 1A28 Ki = 5.1 nM STR C21 H30 O2 CC(=O)[C@H....
58 1ZUC ic50 = 1.7 nM T98 C16 H15 N3 O S CC1(c2cc(c....
59 3ZR7 - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
60 1SR7 Kd = 0.08 nM MOF C27 H30 Cl2 O6 C[C@@H]1C[....
61 3D90 - NOG C21 H28 O2 CC[C@]12CC....
62 3VHV ic50 = 510 nM LD1 C18 H13 N5 O2 S c1ccc(cc1)....
63 2AB2 - SNL C24 H32 O4 S CC(=O)S[C@....
64 2AA2 - AS4 C21 H28 O5 C[C@]12CCC....
65 1YA3 - STR C21 H30 O2 CC(=O)[C@H....
66 2AAX - PDN C21 H26 O5 C[C@]12CC(....
67 2AA7 - 1CA C21 H30 O3 C[C@]12CC[....
68 2OAX - SNL C24 H32 O4 S CC(=O)S[C@....
69 1Y9R - 1CA C21 H30 O3 C[C@]12CC[....
70 4PF3 ic50 = 71 nM HFN C21 H18 F3 N3 O3 Cc1c(c(n(n....
71 2AA6 - STR C21 H30 O2 CC(=O)[C@H....
72 2Q3Y - PRO ALA ILE LEU TYR ALA LEU LEU SER SER n/a n/a
73 4LTW - STR C21 H30 O2 CC(=O)[C@H....
74 2Q1H - AS4 C21 H28 O5 C[C@]12CCC....
75 2Q1V - PDN C21 H26 O5 C[C@]12CC(....
76 1NHZ - 486 C29 H35 N O2 CC#C[C@@]1....
50% Homology Family (78)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 145 families.
1 3RY9 - 1CA C21 H30 O3 C[C@]12CC[....
2 1I38 - DHT C19 H30 O2 C[C@]12CCC....
3 1XNN Ki = 0.5 nM HYQ C20 H18 N2 O4 c1ccc2c(c1....
4 2PIP - ICO C9 H7 N O2 c1ccc2c(c1....
5 2AMA - DHT C19 H30 O2 C[C@]12CCC....
6 1E3G - R18 C19 H24 O2 C[C@@]1(CC....
7 2AX9 Ki = 0.3 nM BHM C11 H10 Br F3 N2 O4 C[C@](CBr)....
8 2AMB - 17H C21 H28 O2 CC[C@@]1(C....
9 4OEA - DHT C19 H30 O2 C[C@]12CCC....
10 3B67 - B67 C17 H10 F8 N2 O5 C[C@](COc1....
11 3RLL - RLL C23 H16 F3 N3 O3 C[C@](COc1....
12 2PIU - DHT C19 H30 O2 C[C@]12CCC....
13 2AXA Ki = 6.1 nM FHM C17 H14 F4 N2 O5 C[C@](COc1....
14 2YLO - TES C19 H28 O2 C[C@]12CC[....
15 2PNU - ENM C27 H36 F2 O3 C[C@]12CCC....
16 4HLW - 17W C15 H14 N2 O S c1ccc(cc1)....
17 2PIQ - RB1 C16 H19 N5 O CC(C)(C)n1....
18 2HVC - LGD C14 H9 F9 N2 O c1cc2c(cc1....
19 2OZ7 - CA4 C24 H29 Cl O4 CC(=O)[C@]....
20 3B65 - 3B6 C18 H14 I N3 O3 C[C@](COc1....
21 2IHQ Ki = 3.2 nM LG7 C17 H13 N3 O3 c1ccc2c(c1....
22 3B68 - B68 C19 H18 F3 N3 O6 CC(=O)Nc1c....
23 3B5R - B5R C18 H13 Cl F4 N2 O3 C[C@](COc1....
24 2AX8 - FHM C17 H14 F4 N2 O5 C[C@](COc1....
25 2PIV - T3 C15 H12 I3 N O4 c1cc(c(cc1....
26 2PIX - FLF C14 H10 F3 N O2 c1ccc(c(c1....
27 2QPY - DHT C19 H30 O2 C[C@]12CCC....
28 2PIR - NK C7 H6 O2 c1ccc(c(c1....
29 2YHD Ki = 23 uM AV6 C17 H14 N2 O2 c1cc2cccc3....
30 1T7T - DHT C19 H30 O2 C[C@]12CCC....
31 1Z95 Kd = 0.76 nM 198 C18 H14 F4 N2 O4 S C[C@](CS(=....
32 3RLJ - RLJ C19 H14 F3 N3 O3 C[C@](COc1....
33 2AX6 - HFT C11 H11 F3 N2 O4 CC(C)(C(=O....
34 2PKL - DHT C19 H30 O2 C[C@]12CCC....
35 2AX7 - FHM C17 H14 F4 N2 O5 C[C@](COc1....
36 2PIO - DHT C19 H30 O2 C[C@]12CCC....
37 3ZQT - TES C19 H28 O2 C[C@]12CC[....
38 1GS4 - ZK5 C21 H29 F O5 C[C@]12CCC....
39 2AM9 - TES C19 H28 O2 C[C@]12CC[....
40 3B66 - B66 C18 H16 F3 N3 O5 C[C@](COc1....
41 1XQ3 - R18 C19 H24 O2 C[C@@]1(CC....
42 2PIT - DHT C19 H30 O2 C[C@]12CCC....
43 3G0W Ki = 0.3 nM LGB C15 H13 Cl F3 N3 O2 Cc1c(ccc(c....
44 4OJB - 198 C18 H14 F4 N2 O4 S C[C@](CS(=....
45 2YLQ - TES C19 H28 O2 C[C@]12CC[....
46 1I37 - DHT C19 H30 O2 C[C@]12CCC....
47 2YLP - TES C19 H28 O2 C[C@]12CC[....
48 3ZRA - ORB C18 H17 Cl F N3 O3 S Cc1c(c(on1....
49 1SQN Kd = 0.4 nM NDR C20 H26 O2 C[C@]12CC[....
50 3G8O ic50 = 125 nM 30X C15 H15 F6 N3 O C[C@@H](C(....
51 3ZRB - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
52 3KBA ic50 = 16 nM WOW C20 H22 Cl N3 O2 S Cc1ccccc1C....
53 4A2J - AS0 C28 H35 N O4 C[C@]12C[C....
54 2W8Y - NDR C20 H26 O2 C[C@]12CC[....
55 4APU - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
56 3HQ5 ic50 = 16 nM GKK C20 H19 Cl F3 N3 C[N@]1CC[C....
57 1A28 Ki = 5.1 nM STR C21 H30 O2 CC(=O)[C@H....
58 1ZUC ic50 = 1.7 nM T98 C16 H15 N3 O S CC1(c2cc(c....
59 3ZR7 - OR8 C17 H19 Cl N4 O3 S Cc1c(c(on1....
60 1SR7 Kd = 0.08 nM MOF C27 H30 Cl2 O6 C[C@@H]1C[....
61 3D90 - NOG C21 H28 O2 CC[C@]12CC....
62 3VHU ic50 = 49 nM SNL C24 H32 O4 S CC(=O)S[C@....
63 2AA5 - STR C21 H30 O2 CC(=O)[C@H....
64 3VHV ic50 = 510 nM LD1 C18 H13 N5 O2 S c1ccc(cc1)....
65 2AB2 - SNL C24 H32 O4 S CC(=O)S[C@....
66 2AA2 - AS4 C21 H28 O5 C[C@]12CCC....
67 1YA3 - STR C21 H30 O2 CC(=O)[C@H....
68 2AAX - PDN C21 H26 O5 C[C@]12CC(....
69 2AA7 - 1CA C21 H30 O3 C[C@]12CC[....
70 2OAX - SNL C24 H32 O4 S CC(=O)S[C@....
71 1Y9R - 1CA C21 H30 O3 C[C@]12CC[....
72 4PF3 ic50 = 71 nM HFN C21 H18 F3 N3 O3 Cc1c(c(n(n....
73 2AA6 - STR C21 H30 O2 CC(=O)[C@H....
74 2Q3Y - PRO ALA ILE LEU TYR ALA LEU LEU SER SER n/a n/a
75 4LTW - STR C21 H30 O2 CC(=O)[C@H....
76 2Q1H - AS4 C21 H28 O5 C[C@]12CCC....
77 2Q1V - PDN C21 H26 O5 C[C@]12CC(....
78 1NHZ - 486 C29 H35 N O2 CC#C[C@@]1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: STR; Similar ligands found: 12
No: Ligand ECFP6 Tc MDL keys Tc
1 STR 1 1
2 1CA 0.732394 0.775
3 TES 0.619718 0.833333
4 FFA 0.619718 0.833333
5 3G6 0.618421 0.861111
6 TH2 0.554217 0.775
7 K2B 0.542169 0.852941
8 DL4 0.54023 0.794872
9 ASD 0.520548 1
10 PLO 0.433735 0.857143
11 CI2 0.419753 0.870968
12 C0R 0.411111 0.738095
Similar Binding Sites
Pocket no: 1; Query (leader) PDB : 1SR7; Ligand: MOF; Similar sites found: 434
This union binding pocket (no: 1) in the query (biounit: 1sr7.bio1) has 29 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 1SR7 MOF 1.052e-18 1
2 3VHU SNL 3.529e-13 0.73269
3 2Q1H AS4 1.019e-10 0.71754
4 3MNP DEX 3.134e-11 0.71203
5 2AX9 BHM 8.872e-10 0.7057
6 4P6W MOF 7.806e-13 0.68195
7 2I0G I0G 5.579e-10 0.68135
8 1M2Z DEX 1.032e-12 0.66715
9 4E2J MOF 2.596e-13 0.66699
10 2QE4 JJ3 1.54e-09 0.66381
11 2A3I C0R 4.764e-12 0.6319
12 2B1Z 17M 1.277e-09 0.62729
13 4OAR 2S0 8.643e-12 0.62515
14 4CSJ NN7 5.12e-11 0.61493
15 3BQD DAY 8.438e-11 0.61279
16 4OKX 198 2.359e-09 0.60307
17 3GN8 DEX 2.04e-11 0.59202
18 3V49 PK0 1.663e-08 0.58255
19 4OHA HFT 3.361e-09 0.57492
20 2Q7J TES 1.211e-10 0.56827
21 1U3R 338 1.855e-09 0.56781
22 2YJD YJD 5.314e-10 0.56172
23 4P6X HCY 1.097e-10 0.56021
24 3RY9 1CA 6.622e-11 0.55924
25 1NHZ 486 2.121e-09 0.55348
26 4OKW 198 2.635e-08 0.54477
27 1T5Z DHT 3.233e-10 0.53399
28 4POJ 2VP 2.344e-07 0.5337
29 3L3X DHT 1.584e-09 0.52977
30 2BJ4 OHT 4.701e-09 0.5243
31 1T74 DHT 3.802e-10 0.51747
32 4MGB XDH 7.579e-10 0.51711
33 1T73 DHT 8.994e-10 0.51275
34 1T79 DHT 8.006e-10 0.51011
35 3KFC 61X 7.844e-06 0.50965
36 1YYE 196 1.498e-08 0.50825
37 1T7M DHT 1.759e-09 0.50637
38 1T7F DHT 2.641e-09 0.50313
39 3OLL EST 1.802e-08 0.50155
40 4MG8 27J 1.313e-08 0.50046
41 3FAL LO2 1.225e-05 0.49848
42 2HFP NSI 2.087e-05 0.49793
43 2QZO KN1 2.068e-08 0.49635
44 2AO6 R18 3.033e-09 0.49604
45 4M8E 29V 5.563e-07 0.49395
46 3GZ9 D32 4.43e-05 0.49333
47 2HC4 VDX 1.531e-05 0.49284
48 4J26 EST 2.65e-09 0.4924
49 4J24 EST 1.353e-08 0.49077
50 3VRV YSD 3.84e-05 0.4904
51 1T65 DHT 8.722e-09 0.48755
52 4FHH 0U3 2.656e-05 0.48723
53 3L3Z DHT 9.619e-09 0.48563
54 1T7R DHT 2.311e-09 0.48542
55 1FBY REA 1.506e-05 0.48404
56 3G9E RO7 3.195e-05 0.48235
57 3KDU NKS 6.464e-05 0.48136
58 2GIU FBR 0.0001322 0.47985
59 3B1M KRC 9.533e-05 0.47463
60 2P4Y C03 0.0001531 0.47387
61 1DB1 VDX 8.091e-05 0.47161
62 1DKF BMS 9.656e-06 0.46805
63 2E2R 2OH 0.0006398 0.46232
64 3UUA 0CZ 3.459e-09 0.45654
65 3UUD EST 5.752e-09 0.45634
66 1FCY 564 4.478e-05 0.45541
67 4LSJ LSJ 0.0006012 0.45472
68 1RDT L79 2.498e-06 0.453
69 3LMP CEK 0.0002431 0.45135
70 3BEJ MUF 3.876e-06 0.45044
71 4MG7 27H 2.567e-07 0.44967
72 3KMZ EQO 2.159e-05 0.44779
73 3FAL REA 1.241e-06 0.44681
74 4DK7 0KS 1.602e-05 0.44476
75 1FM9 9CR 3.849e-06 0.44158
76 1FCZ 156 6.208e-05 0.44116
77 3H0A 9RA 1.405e-05 0.44034
78 1T76 DHT 9.95e-09 0.43978
79 4DM8 REA 8.911e-05 0.43794
80 3PLZ 470 0.0002334 0.43509
81 3RUU 37G 0.0002087 0.43206
82 2QA8 GEN 1.097e-06 0.42609
83 4QJR PIZ 0.000467 0.42568
84 3KMR EQN 4.941e-05 0.42449
85 4WLB 3QQ 0.001122 0.42395
86 2JF9 OHT 0.002785 0.42145
87 1FM9 570 0.0003739 0.42087
88 1M13 HYF 0.0002706 0.42085
89 1RDT 570 0.0001211 0.41994
90 3L0E G58 0.0003922 0.41711
91 3OKI OKI 0.002692 0.4143
92 2O4J VD4 0.0005585 0.41426
93 1DKF OLA 2.025e-05 0.41307
94 1XAP TTB 4.959e-05 0.412
95 3FEI CTM 0.0003154 0.4109
96 1ZDU P3A 0.0004102 0.40938
97 4QRT GLU 0.003675 0.40774
98 1MI5 PHE 0.004368 0.40713
99 1FM4 DXC 0.005405 0.4067
100 3UU7 2OH 1.91e-07 0.40518
101 3DCT 064 0.0003307 0.40447
102 4MGA 27L 2.232e-09 0.40399
103 4HBM 0Y7 0.002656 0.40247
104 3Q8G PEE 0.01142 0.40165
105 1JUF SER 0.006425 0.40155
106 1YMT DR9 0.0007228 0.40103
107 3JZB 4HY 0.005367 0.40002
108 4MGD 27N 8.644e-07 0.39846
109 3SP6 IL2 5.496e-05 0.39842
110 1Y4L SVR 0.02276 0.3968
111 1OSH FEX 0.004816 0.39656
112 4MG9 27K 8.035e-09 0.39645
113 1YUC EPH 0.0007526 0.39347
114 4EN4 ATP 0.01038 0.39213
115 1YP0 PEF 0.000418 0.39135
116 2P54 735 0.0008946 0.39042
117 2XXP DSL 0.01241 0.39008
118 4IGH 1EA 0.02784 0.38978
119 1XVB BHL 0.02836 0.38943
120 1N46 PFA 0.002905 0.3889
121 4KVS 6NA 0.01053 0.38847
122 3BZF VAL 0.0114 0.38827
123 4OAS 2SW 0.007965 0.38812
124 1PZO CBT 0.0217 0.3876
125 3BHB LYS 0.02126 0.38627
126 4RC7 PL3 0.0004306 0.38427
127 2NPA MMB 0.0005731 0.38417
128 1K7L 544 0.001834 0.38391
129 3L0L HC3 0.001925 0.38069
130 2Z7I 742 0.02328 0.38007
131 4RC8 STE 0.001863 0.3799
132 4LY9 1YY 0.02969 0.37942
133 3V66 D3A 0.02386 0.37864
134 4QRQ HIS 0.01422 0.37837
135 4OOE FOM 0.03528 0.378
136 2H26 6UL 0.03728 0.37781
137 4O2C ACE 0.04828 0.3775
138 3T58 FAD 0.00818 0.37741
139 2PRG BRL 0.0002744 0.37714
140 2E3N 6CM 0.02073 0.37683
141 4QRS GLU 0.0266 0.37573
142 4AZP A9M 0.004473 0.37555
143 3ET1 ET1 0.0004922 0.37484
144 4PHW 2W1 0.02746 0.37414
145 4BVN P32 0.006867 0.37338
146 3HR1 PF9 0.003411 0.37325
147 1S7X LYS 0.02091 0.37313
148 4P3H 25G 0.004572 0.37295
149 1S7U LYS 0.02364 0.37225
150 1T27 PCW 0.02813 0.37156
151 3NJQ NJQ 0.0009081 0.37154
152 3R1V AZB 0.007413 0.3714
153 4F4P 0SB 0.03617 0.37132
154 2R40 EPH 0.003412 0.37086
155 2QHD DAO 0.04363 0.37077
156 1N8V BDD 0.01991 0.37028
157 4JFF GLU 0.03457 0.37011
158 3QCP FAD 0.007953 0.36977
159 2VZZ SCA 0.01756 0.36967
160 2R40 20E 0.006105 0.36933
161 1JQ9 PHE 0.02884 0.36885
162 2Z6C FMN 0.004548 0.3686
163 3RG9 NDP 0.0423 0.36855
164 3T50 FMN 0.00449 0.36847
165 4L8D ALA 0.02206 0.36784
166 2Z6D FMN 0.004943 0.36777
167 4R38 RBF 0.003795 0.36683
168 1U3U NAD 0.04988 0.36656
169 1N9L FMN 0.005092 0.36649
170 4H07 IPH 0.0115 0.36591
171 3K3K A8S 0.004966 0.36587
172 1NRL SRL 0.001232 0.36577
173 4D09 788 0.02032 0.36552
174 2ZCQ B65 0.04775 0.36543
175 2YG2 FLC 0.01995 0.36524
176 1XVB 3BR 0.04866 0.3651
177 2QZT PLM 0.01536 0.36462
178 1N83 CLR 0.009827 0.3643
179 1N4H REA 0.006575 0.36422
180 3NMH PYV 0.01018 0.36421
181 2V0U FMN 0.007236 0.36415
182 4GCZ FMN 0.006545 0.36379
183 4Q9M 2ZW 0.03661 0.36357
184 3B6C SDN 0.003534 0.3629
185 3FS1 MYR 0.0002346 0.36265
186 2ART LPA 0.03807 0.36169
187 4ONC 40B 0.03431 0.36142
188 1PZL MYR 0.0007571 0.36142
189 1ZDT PEF 0.00745 0.36129
190 4QC6 30N 0.007388 0.36107
191 1X0P FAD 0.003263 0.36104
192 2WKQ FMN 0.00836 0.36065
193 4F7E 0SH 0.006177 0.36019
194 3GYT DL4 0.008604 0.36017
195 3A7R LAQ 0.04772 0.36017
196 3H78 BE2 0.04649 0.35947
197 3QKD HI0 0.03892 0.35873
198 4EES FMN 0.009344 0.35847
199 3GFZ FMN 0.004168 0.35821
200 3JUQ AKD 0.01295 0.35821
201 3VVY ET 0.03425 0.35802
202 4LWU 20U 0.001615 0.35796
203 3P7N FMN 0.008999 0.35756
204 1XIU REA 0.04175 0.35736
205 4HIA FMN 0.009877 0.35713
206 4PXZ 6AD 0.02077 0.35664
207 2PR5 FMN 0.009311 0.3554
208 3FEA ACE 0.001894 0.35489
209 2BCG GER 0.001168 0.35433
210 4O1Z MXM 0.0111 0.35413
211 3IX8 TX3 0.03527 0.3541
212 2PQB GG9 0.02682 0.35406
213 1S7W LYS 0.03485 0.35366
214 1KVO OAP 0.01157 0.35309
215 3L9R L9Q 0.04457 0.35291
216 1OQC FAD 0.03108 0.35241
217 2VBA P4T 0.04345 0.35191
218 2IW1 U2F 0.04117 0.35184
219 1QV1 CZH 0.04961 0.35124
220 1G2N EPH 0.00733 0.35108
221 3GWL FAD 0.03276 0.35094
222 3NHT U46 0.01808 0.34993
223 1YC4 43P 0.003143 0.34962
224 4I6G FAD 0.04119 0.34931
225 4BVM PLM 0.01667 0.34926
226 4EJ1 FOL 0.005517 0.34921
227 3HY9 098 0.01946 0.34892
228 1DEK DGP 0.01796 0.34862
229 1Z8O DEB 0.02962 0.34839
230 3AHO 3A2 0.04694 0.34804
231 1JF0 CZH 0.01792 0.348
232 3KPX CZH 0.01273 0.3477
233 2R75 01G 0.0314 0.34706
234 3CV0 ASN 0.01242 0.34658
235 1I00 UMP 0.03597 0.34648
236 4QA8 PJZ 0.02645 0.34633
237 2BYC FMN 0.006589 0.34574
238 3GWN FAD 0.009486 0.3456
239 1UKW FAD 0.02046 0.34554
240 2GFD RDA 0.0337 0.34534
241 1GHE ACO 0.031 0.34518
242 2ADA HPR 0.02003 0.34483
243 4GV4 MEJ 0.02276 0.34466
244 1FK5 OLA 0.02906 0.3439
245 1ONQ SLF 0.04287 0.34294
246 1OSV CHC 0.006349 0.34285
247 2UXI G50 0.01579 0.34226
248 3C8Z 5CA 0.03903 0.34222
249 3OVR 5SP 0.01647 0.34222
250 4HW3 19G 0.03378 0.34151
251 2HFN FMN 0.018 0.34146
252 3KTI OTT 0.01879 0.34096
253 4BNU 9KQ 0.03061 0.34073
254 2WCJ M21 0.0341 0.34071
255 4GBD MCF 0.02648 0.34063
256 1EE4 PRO 0.03925 0.3406
257 2HJ3 FAD 0.03504 0.34039
258 4IBF 1D5 0.0168 0.34036
259 1S17 GNR 0.009442 0.34026
260 4MW0 392 0.03756 0.34015
261 1CXZ GSP 0.0253 0.33949
262 1JR8 FAD 0.04894 0.33916
263 4Q0A 4OA 0.04288 0.33908
264 3UP3 XCA 0.04891 0.33845
265 3JRX S1A 0.01411 0.33845
266 1TMX HGX 0.005198 0.33758
267 3QDC RET 0.02958 0.33755
268 2HW2 RFP 0.01371 0.33755
269 3IA4 MTX 0.02066 0.33612
270 1R5L VIV 0.03968 0.33555
271 2W2X GSP 0.03435 0.33549
272 3AB3 GDP 0.0436 0.33532
273 3H0A D30 0.02372 0.33483
274 3TH5 GNP 0.03761 0.33482
275 1VYF OLA 0.04853 0.33479
276 3F8K COA 0.03797 0.33448
277 1VCE SAH 0.04216 0.33429
278 4GFD 0YB 0.03086 0.33398
279 2GCO GNP 0.04129 0.33396
280 1NF3 GNP 0.04834 0.33384
281 2Q4H AMP 0.04695 0.33376
282 1Q3A NGH 0.007116 0.33321
283 4OAV ACP 0.02783 0.33315
284 4BUP SAM 0.03867 0.33312
285 1HMR ELA 0.01984 0.33286
286 3KB9 BTM 0.03228 0.3327
287 4U5X GNP 0.04523 0.33258
288 4BIX ADP 0.008197 0.33241
289 1OFU GDP 0.03207 0.33222
290 1M7B GTP 0.04351 0.33206
291 3CHT 4NB 0.001729 0.33197
292 1YRX FMN 0.01405 0.33176
293 1P1M MET 0.0494 0.33172
294 1MF4 VAL 0.04034 0.33169
295 1S8G DAO 0.005812 0.33145
296 2EW5 Y12 0.03994 0.33082
297 1WS1 BB2 0.02557 0.33066
298 3DZT EAH 0.04042 0.3305
299 3UBQ SIA 0.03334 0.32994
300 3PDB PMP 0.01587 0.32976
301 3G5K BB2 0.02829 0.32896
302 4DS8 A8S 0.01307 0.32879
303 3EUF BAU 0.04157 0.32861
304 2WOR 2AN 0.03735 0.32841
305 2VL8 UDP 0.04594 0.32832
306 1T0I FMN 0.02427 0.32819
307 1XMU ROF 0.02597 0.32791
308 2J90 IZA 0.04219 0.32749
309 2D09 FLV 0.04057 0.32722
310 3OGN 3OG 0.009676 0.32713
311 3ETG GTP 0.008653 0.32683
312 4O6M C5P 0.04537 0.32678
313 4JE7 BB2 0.03793 0.32652
314 3S0E EOL 0.03166 0.3265
315 2RH1 CAU 0.02391 0.32643
316 3PD6 PMP 0.02545 0.32635
317 2W14 WR2 0.03184 0.32612
318 1ELR ACE 0.0304 0.32583
319 2O5L MNR 0.03191 0.32572
320 2J0V GDP 0.03581 0.32548
321 2WPX ACO 0.04113 0.32545
322 3WBG 2AN 0.0123 0.32544
323 1OT6 HC4 0.02659 0.32527
324 1DS6 GDP 0.03408 0.3252
325 4DID GDP 0.03542 0.32514
326 1NQ7 ARL 0.01326 0.3248
327 4BTB PRO 0.003098 0.32418
328 4QBK 3NZ 0.01314 0.32345
329 1M2Z BOG 0.002928 0.32312
330 1XN0 ROL 0.01335 0.32286
331 1Q1Y BB2 0.04655 0.3221
332 1NBU PH2 0.04066 0.322
333 4L77 CNL 0.0375 0.32188
334 4LH7 NMN 0.01752 0.32166
335 1PA9 CSN 0.04537 0.32143
336 2FHK MFN 0.04262 0.32107
337 1OW3 GDP 0.03915 0.32103
338 2H92 C5P 0.04423 0.32078
339 2RI7 ALA 0.04739 0.32077
340 3TL1 JRO 0.007934 0.32006
341 4Q86 AMP 0.03148 0.31987
342 3DWB RDF 0.01213 0.31941
343 3GL0 HXX 0.04551 0.31929
344 1G4U GDP 0.04479 0.31902
345 4I67 G 0.03767 0.31882
346 2WPW ACO 0.04167 0.31825
347 2HU5 GLY 0.04867 0.31771
348 4WKI 3PW 0.04911 0.3174
349 1ID0 ANP 0.04837 0.31719
350 3CXW 7CP 0.03023 0.31715
351 4U0S ADP 0.03397 0.31688
352 4Q0A GLY 0.02255 0.31676
353 4Q0K GA3 0.02904 0.31574
354 1Q20 PLO 0.01418 0.3142
355 4DOL PLM 0.01496 0.31375
356 3I6B KDO 0.006198 0.31359
357 2WJG GDP 0.03776 0.31302
358 1CZA ADP 0.02409 0.31252
359 4NY3 PRO 0.001879 0.31178
360 4N6H EJ4 0.02971 0.31099
361 4INW 1EY 0.04324 0.31089
362 1MFI FHC 0.01956 0.3104
363 4MA7 P2Z 0.01138 0.31012
364 2YFJ 1IT 0.04669 0.3093
365 3KZE ARG 0.04868 0.3093
366 4OB1 BUB 0.002133 0.30855
367 4EIY ZMA 0.02146 0.30831
368 3CY2 MB9 0.0226 0.30813
369 2QQD AG2 0.03219 0.30775
370 2AK3 AMP 0.03757 0.30641
371 2PX8 MGT 0.03198 0.30613
372 4ARE FLC 0.008662 0.30605
373 4WLB SER 0.01769 0.30589
374 2XCB ARG 0.0499 0.30559
375 4OB0 PBC 0.0108 0.30518
376 3RLF MAL 0.01165 0.30474
377 4UYG 73B 0.02234 0.30418
378 4IHL 1F5 0.03101 0.30363
379 1ALW ISA 0.04948 0.30239
380 4BHL ARG 0.03026 0.30238
381 1WB4 SXX 0.03535 0.30213
382 2XEM SSV 0.03365 0.30211
383 3HYW DCQ 0.01817 0.30086
384 2VNO GAL 0.02128 0.30078
385 4C91 REL 0.03915 0.30071
386 3CYI ATP 0.02706 0.30043
387 4NOS H2B 0.02511 0.29984
388 2Z9I ALA 0.01826 0.29983
389 3LXI CAM 0.04343 0.29956
390 2UW1 GVM 0.01686 0.29905
391 4KV4 THR 0.04049 0.29886
392 4IA6 EIC 0.002014 0.29868
393 3HP9 CF1 0.009719 0.29843
394 2PSJ CEI 0.01924 0.29801
395 2W3L DRO 0.03153 0.29744
396 1VRP IOM 0.01961 0.29732
397 4NOS H4B 0.04281 0.29674
398 3SQP 3J8 0.03618 0.29569
399 2P41 G1G 0.03044 0.29546
400 3BJC WAN 0.04859 0.29543
401 2ZPG TB0 0.02758 0.29455
402 2BP1 FLC 0.01532 0.29431
403 2XUA SHF 0.03842 0.29346
404 4MRP GSH 0.006751 0.29343
405 1GVE CIT 0.03101 0.29343
406 4L80 OXL 0.04821 0.29291
407 2ATJ BHO 0.04791 0.29287
408 2Q4X HMH 0.02928 0.29239
409 3ETG GWD 0.004282 0.29082
410 1NQ7 HIS 0.02829 0.29065
411 3AI3 SOE 0.04296 0.29057
412 3ZQE DXC 0.02194 0.29023
413 3BRE C2E 0.04883 0.28988
414 3RLB VIB 0.03273 0.28937
415 1DL2 NAG 0.04952 0.28936
416 4CP9 GAL 0.04761 0.28906
417 2V57 PRL 0.04089 0.28904
418 1N13 AG2 0.03477 0.28849
419 1L0I PSR 0.04162 0.28826
420 3DTU DXC 0.02738 0.28815
421 3O01 DXC 0.0004239 0.288
422 3AQT RCO 0.01418 0.28759
423 2QJY UQ2 0.02212 0.28689
424 3SXU ASP 0.0008989 0.28663
425 2XN3 ID8 0.03417 0.28625
426 2BHW XAT 0.03547 0.28432
427 3RV5 DXC 0.004439 0.2835
428 3TDC 0EU 0.001152 0.28327
429 4N9Z V3L 0.03591 0.2824
430 3F33 PFL 0.008875 0.28051
431 4QEK GLC 0.02765 0.27951
432 2BHW NEX 0.006375 0.27715
433 1W1G 4PT 0.04179 0.27667
434 2CIX CEJ 0.0337 0.26915
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