Receptor
PDB id Resolution Class Description Source Keywords
1A4I 1.5 Å EC: 1.5.1.5 HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE HOMO SAPIENS THF BIFUNCTIONAL DEHYDROGENASE CYCLOHYDROLASE FOLATE OXIDOREDUCTASE
Ref.: THE 3-D STRUCTURE OF A FOLATE-DEPENDENT DEHYDROGENASE/CYCLOHYDROLASE BIFUNCTIONAL ENZYME AT 1.5 A RESOLUTION. STRUCTURE V. 6 173 1998
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NDP A:302;
B:302;
Valid;
Valid;
none;
none;
submit data
745.421 C21 H30 N7 O17 P3 c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1DIG 2.2 Å EC: 1.5.1.5 HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571 HOMO SAPIENS TETRAHYDROFOLATE DEHYDROGENASE CYCLOHYDROLASE NADP INHIBITOR ROSSMANN FOLD OXIDOREDUCTASEHYDROLASE
Ref.: STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDE INSIGHT INTO THE REACTION MECHANISM OF THE HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE. BIOCHEMISTRY V. 39 6325 2000
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1DIA Ki = 455 uM L24 C21 H25 N5 O6 c1cc(ccc1C....
2 1A4I - NDP C21 H30 N7 O17 P3 c1nc(c2c(n....
3 1DIG Ki = 431 uM L37 C17 H19 N7 O7 c1cc(ccc1C....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1DIA Ki = 455 uM L24 C21 H25 N5 O6 c1cc(ccc1C....
2 1A4I - NDP C21 H30 N7 O17 P3 c1nc(c2c(n....
3 1DIG Ki = 431 uM L37 C17 H19 N7 O7 c1cc(ccc1C....
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1DIA Ki = 455 uM L24 C21 H25 N5 O6 c1cc(ccc1C....
2 1A4I - NDP C21 H30 N7 O17 P3 c1nc(c2c(n....
3 1DIG Ki = 431 uM L37 C17 H19 N7 O7 c1cc(ccc1C....
4 3NGL - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4B4U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4B4W - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
7 4B4V - L34 C20 H21 N7 O7 c1cc(ccc1C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: NDP; Similar ligands found: 138
No: Ligand ECFP6 Tc MDL keys Tc
1 NDP 1 1
2 0WD 0.827273 1
3 NAI 0.803738 0.986842
4 NMN AMP PO4 0.794643 0.948052
5 NPW 0.692308 0.962025
6 NZQ 0.686441 0.987013
7 DG1 0.68 1
8 1DG 0.68 1
9 A2R 0.650943 0.909091
10 A22 0.64486 0.934211
11 TXP 0.644628 0.924051
12 ATR 0.640777 0.894737
13 NA7 0.636364 0.886076
14 AP0 0.598361 0.948718
15 A2P 0.598039 0.881579
16 NJP 0.574803 0.923077
17 25L 0.550847 0.934211
18 ODP 0.550388 0.936709
19 NAX 0.544 0.949367
20 25A 0.53913 0.921053
21 2AM 0.529412 0.87013
22 NAP 0.514493 0.922078
23 EAD 0.507143 0.949367
24 A2D 0.504673 0.921053
25 NA0 0.496454 0.910256
26 TXD 0.496124 0.911392
27 AGS 0.495575 0.875
28 SAP 0.495575 0.875
29 P1H 0.493056 0.925926
30 CO7 0.489796 0.791209
31 TAP 0.489362 0.864198
32 PAP 0.482456 0.907895
33 BA3 0.481818 0.921053
34 NAJ PZO 0.478261 0.924051
35 ATP 0.477876 0.921053
36 B4P 0.477477 0.921053
37 AP5 0.477477 0.921053
38 ADP 0.477477 0.921053
39 OAD 0.47541 0.897436
40 5FA 0.473684 0.921053
41 APR 0.473684 0.896104
42 AQP 0.473684 0.921053
43 AR6 0.473684 0.896104
44 3OD 0.467742 0.897436
45 50T 0.464912 0.884615
46 PO4 PO4 A A A A PO4 0.463415 0.857143
47 V3L 0.461538 0.896104
48 2A5 0.46087 0.85
49 4AD 0.459016 0.875
50 ADQ 0.459016 0.897436
51 A1R 0.459016 0.841463
52 OVE 0.458716 0.8375
53 PPS 0.457627 0.811765
54 AD9 0.456897 0.897436
55 M33 0.45614 0.884615
56 CA0 0.45614 0.897436
57 ADJ 0.455882 0.879518
58 A3P 0.455357 0.894737
59 ACP 0.452174 0.897436
60 ENP 0.451613 0.85
61 UP5 0.451128 0.948052
62 SRP 0.45 0.8625
63 ANP 0.449153 0.897436
64 ACQ 0.449153 0.897436
65 PRX 0.448276 0.82716
66 5AL 0.445378 0.884615
67 ADX 0.443478 0.811765
68 A 0.436364 0.894737
69 AMP 0.436364 0.894737
70 4TC 0.433824 0.924051
71 DCA 0.433566 0.788889
72 ETB 0.433566 0.797753
73 BIS 0.433071 0.864198
74 1ZZ 0.433071 0.802326
75 00A 0.432 0.864198
76 ATF 0.429752 0.886076
77 3AM 0.427273 0.857143
78 N01 0.426573 0.884615
79 LAD 0.425197 0.821429
80 PR8 0.425197 0.811765
81 DTP 0.425 0.8375
82 AMO 0.424 0.886076
83 PAJ 0.424 0.843373
84 APC 0.423729 0.886076
85 UPA 0.423358 0.935897
86 PTJ 0.421875 0.853659
87 FYA 0.421875 0.860759
88 CNA 0.421429 0.910256
89 PUA 0.42069 0.9125
90 NXX 0.419118 0.910256
91 DND 0.419118 0.910256
92 AV2 0.418033 0.848101
93 COA 0.417808 0.788889
94 DAT 0.415254 0.8375
95 NDO 0.414966 0.897436
96 139 0.414286 0.901235
97 TAT 0.413223 0.886076
98 3AT 0.413223 0.896104
99 YLB 0.413043 0.784091
100 ABM 0.412281 0.848101
101 YAP 0.412214 0.875
102 YLP 0.411765 0.784091
103 ME8 0.410853 0.802326
104 NB8 0.410853 0.853659
105 SON 0.410256 0.886076
106 AHX 0.409449 0.853659
107 DLL 0.409449 0.909091
108 CAO 0.409396 0.763441
109 COS 0.409396 0.771739
110 30N 0.409396 0.72449
111 AMX 0.409396 0.797753
112 APX 0.407692 0.841463
113 SRA 0.40708 0.85
114 CMX 0.406667 0.788889
115 SCO 0.406667 0.788889
116 TYM 0.405797 0.886076
117 COD 0.405594 0.777778
118 OXK 0.405229 0.771739
119 CA6 0.405229 0.70297
120 AP2 0.405172 0.886076
121 A12 0.405172 0.886076
122 LAQ 0.404412 0.802326
123 T5A 0.404255 0.914634
124 FAM 0.403974 0.771739
125 FCX 0.403974 0.763441
126 ACO 0.403974 0.763441
127 AMP MG 0.403509 0.825
128 ADP VO4 0.403226 0.860759
129 YLC 0.402878 0.823529
130 1VU 0.402597 0.763441
131 FA5 0.401515 0.886076
132 HAX 0.401316 0.771739
133 CAJ 0.4 0.771739
134 AR6 AR6 0.4 0.871795
135 APU 0.4 0.923077
136 AFH 0.4 0.843373
137 A U 0.4 0.898734
138 TXA 0.4 0.886076
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1DIG; Ligand: NAP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1dig.bio1) has 23 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
Pocket No.: 2; Query (leader) PDB : 1DIG; Ligand: L37; Similar sites found: 241
This union binding pocket(no: 2) in the query (biounit: 1dig.bio1) has 34 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 4K28 NAD 2.247e-05 0.50807
2 2HJR APR 5.673e-05 0.50025
3 1O0S NAI 6.938e-05 0.49201
4 1V6A TRE 0.001241 0.49172
5 2HJR APR 7.673e-05 0.49016
6 2HJR APR 8.327e-05 0.48866
7 2HJR APR 8.452e-05 0.48838
8 2HJR APR 8.452e-05 0.48838
9 2HJR APR 8.452e-05 0.48838
10 2HJR APR 8.878e-05 0.48748
11 2HJR APR 9.205e-05 0.48682
12 2HJR APR 9.205e-05 0.48682
13 2HJR APR 9.205e-05 0.48682
14 4K28 NAD 6.676e-05 0.48427
15 2HJR APR 8.419e-05 0.48423
16 2HJR APR 8.419e-05 0.48423
17 2HJR APR 8.419e-05 0.48423
18 2HJR APR 0.0001133 0.483
19 4R68 W31 9.133e-05 0.47945
20 4R68 NAI 9.628e-05 0.47945
21 1T26 GBD 4.056e-05 0.47928
22 1T26 NAI 4.056e-05 0.47928
23 2HJR APR 0.000149 0.47797
24 4J4H 1J1 7.601e-05 0.47571
25 4J4H NAI 7.601e-05 0.47571
26 1GQ2 NAP 7.198e-05 0.47514
27 4J4H 1J1 5.858e-05 0.47446
28 4J4H NAI 6.289e-05 0.47446
29 1EZ4 NAD 9.396e-05 0.47432
30 1GQ2 NAP 7.564e-05 0.47429
31 2CDC XYP 0.0001806 0.47362
32 4J4H 1J1 7.621e-05 0.47352
33 4J4H NAI 7.621e-05 0.47352
34 4J4H NAI 6.742e-05 0.47331
35 3NJ4 AFX 9.47e-05 0.47306
36 4J4H NAI 6.865e-05 0.47301
37 4J4H 1J1 6.397e-05 0.47301
38 2CDC NAP 0.0001891 0.47282
39 2CDC XYS 0.0001891 0.47282
40 3NJ4 NAD 0.0005817 0.47237
41 1UXG NAD 4.964e-05 0.47085
42 1UXG FUM 4.964e-05 0.47085
43 1GQ2 NAP 8.206e-05 0.46923
44 2DT5 NAD 9.512e-05 0.46674
45 4PLG OXM 5.941e-05 0.4666
46 4PLG NAI 5.941e-05 0.4666
47 1GV0 NAD 2.207e-05 0.46521
48 1GQ2 NAP 0.0001076 0.46467
49 4J4H 1J1 0.0001008 0.46438
50 1LDM NAD 8.915e-05 0.46432
51 2A92 NAI 4.457e-05 0.46192
52 1D1T NAD 8.84e-05 0.46105
53 1NYT NAP 0.0002639 0.4599
54 1NYT NAP 0.0002639 0.4599
55 1NYT NAP 0.0002639 0.4599
56 1D1T NAD 8.14e-05 0.45906
57 1D1T NAD 8.14e-05 0.45906
58 4JK3 NAD 2.506e-05 0.45869
59 4JK3 NAD 1.44e-05 0.45869
60 1GUZ NAD 2.64e-05 0.4582
61 4MP8 NAD 0.0001012 0.45804
62 4MP8 MLI 0.0001012 0.45804
63 1U3U BNF 0.0001516 0.45769
64 1U3U NAD 0.0001516 0.45769
65 1V8B NAD 9.544e-05 0.45762
66 2VHW NAI 9.595e-05 0.45754
67 4JK3 NAD 1.661e-05 0.4573
68 1SOW NAD 6.174e-05 0.45679
69 4BVA T3 0.0001257 0.45585
70 4BVA NDP 5.449e-05 0.45547
71 1I0Z NAI 0.0001602 0.4546
72 2DT5 NAD 0.0001932 0.4515
73 1LLU NAD 9.175e-05 0.44948
74 1NPD NAD 0.0005785 0.44944
75 2IZ1 ATR 0.00654 0.44919
76 2FZW NAD 0.0002832 0.44855
77 3GFB NAD 0.0003458 0.44825
78 2GZ3 NAP 0.0004221 0.44801
79 2GZ3 NAP 0.0003988 0.44801
80 1P77 ATR 0.007185 0.44751
81 2F1K NAP 0.0005789 0.44597
82 2IZZ NAD 0.0003964 0.44591
83 1C3V NDP 0.0002407 0.44471
84 1A5Z NAD 0.001113 0.44452
85 9LDB NAD 0.0002508 0.44404
86 3B1F NAD 0.001162 0.4437
87 1VI2 NAD 0.001208 0.44299
88 2CVQ NDP 0.0003928 0.44285
89 2QRK AMP 0.0003002 0.44181
90 1OMO NAD 3.246e-05 0.44
91 3WLE NAD 0.000296 0.4395
92 3JV7 NAD 0.0004099 0.43903
93 1HYH NAD 0.0003611 0.4381
94 1HYH NAD 0.0003611 0.4381
95 1X7D ORN 0.0003508 0.43806
96 1O6Z NAD 3.522e-05 0.43726
97 1HDG NAD 0.0009558 0.43707
98 1LLU NAD 0.0002052 0.43695
99 3ABI NAD 0.0004709 0.43674
100 1EBF NAD 4.809e-05 0.43613
101 3H9E NAD 0.000852 0.4359
102 3QV1 NAD 0.0009465 0.43407
103 1O94 ADP 0.001453 0.43281
104 4W6Z 8ID 0.0004552 0.43262
105 4GKV NAD 0.0003885 0.43252
106 1OBB NAD 0.001488 0.43239
107 2F1K NAP 0.001053 0.43222
108 9LDT NAD 0.0002452 0.43205
109 1NVM NAD 0.0005569 0.43103
110 3VPH NAD 0.0004034 0.43055
111 1E3I CXF 0.0001886 0.42975
112 3QV1 NAD 0.001242 0.42933
113 3QV1 NAD 0.001242 0.42933
114 1X7D NAD 0.0002051 0.42894
115 1LTH NAD 6.178e-05 0.42893
116 4RQU NAD 0.0002052 0.42836
117 1LVL NAD 0.003386 0.42693
118 1J5P NAD 0.001223 0.4266
119 1PZG A3D 0.0001838 0.42635
120 1LTH NAD 0.0001786 0.42572
121 3IP5 ALA 0.0196 0.42553
122 2YVJ NAI 0.005408 0.42461
123 3ETG NDP 0.001987 0.42456
124 4MDH NAD 0.001394 0.42436
125 3ETG GLU 0.002025 0.42424
126 2B5W NAP 0.0003704 0.42418
127 2DFV NAD 0.0002589 0.42358
128 1BW9 NAD 0.003437 0.42339
129 1CER NAD 0.001787 0.42298
130 1LDN NAD 0.000453 0.42294
131 4KOA NDP 0.007014 0.42288
132 1NVM NAD 0.0006625 0.42272
133 1VM6 NAD 0.000132 0.42261
134 1LDN NAD 0.0004698 0.42236
135 2I3G NAP 0.0009863 0.42171
136 2DFV NAD 0.0002485 0.42135
137 1M2W NAD 0.003298 0.42102
138 1PL6 572 0.0007445 0.42087
139 4LWU 20U 0.01105 0.42068
140 1CDO NAD 0.0002025 0.42066
141 2DFV NAD 0.0003211 0.42042
142 3GGO NAI 0.001483 0.42032
143 3GGO ENO 0.001483 0.42032
144 1P0F NAP 0.0006626 0.41987
145 1B8U OAA 0.0006837 0.41974
146 1PL6 572 0.0006852 0.4194
147 1PL6 572 0.0006852 0.4194
148 3VPH OXM 0.0004888 0.41923
149 4W6Z 8ID 0.0009854 0.41902
150 1NVT NAP 0.0001847 0.41881
151 1C1X NAD 0.002274 0.41878
152 1F8F NAD 0.0001819 0.41842
153 1J0X NAD 0.002013 0.41822
154 2WQ4 SFU 0.03539 0.41715
155 3BAZ NAP 0.002949 0.41708
156 2I3G NAP 0.001117 0.41704
157 2I3G NAP 0.001117 0.41704
158 4E5N NAD 0.0006804 0.41703
159 3ETG GTP 0.002069 0.41682
160 2EV9 SKM 0.0008074 0.41682
161 2EV9 NAP 0.0008074 0.41682
162 4E5N NAD 0.0008162 0.4168
163 1DXY NAD 0.0003131 0.41669
164 1DXY NAD 0.0003131 0.41669
165 3V1Y NAD 0.002661 0.41604
166 4E5N NAD 0.000874 0.41574
167 4OOE NDP 0.002761 0.4154
168 1H2B NAJ 0.001069 0.41516
169 1PL6 NAD 0.0001141 0.41502
170 1PL6 NAD 8.561e-05 0.41502
171 1HKU NAD 0.001535 0.4145
172 1J49 NAD 0.0005547 0.41376
173 1GR0 NAD 0.001273 0.41368
174 2PV7 NAD 0.00263 0.41347
175 4E5N NAD 0.0008688 0.41329
176 2GCG NDP 0.002373 0.41254
177 1PL6 NAD 0.0001044 0.4121
178 3QV9 QV7 0.03548 0.41169
179 1YQD NAP 0.001341 0.41157
180 2HK9 NAP 0.0003922 0.41047
181 1GAD NAD 0.0004262 0.41012
182 3CIF G3H 0.001615 0.40991
183 3CIF G3H 0.00149 0.40991
184 1TB4 PEJ 0.002389 0.40981
185 3A06 FOM 0.0019 0.40974
186 1KEV NDP 0.001213 0.4096
187 2GV8 NDP 0.005275 0.40951
188 3T31 DCQ 0.005582 0.40931
189 4KP7 NAP 0.002452 0.40898
190 4R5M NAP 0.002934 0.40895
191 4QX6 NAD 0.00021 0.40885
192 2GSD NAD 0.001868 0.40881
193 3QV1 NAD 0.002962 0.4088
194 2NAD NAD 0.001906 0.40849
195 2HK9 NAP 0.0005687 0.40836
196 3A06 NDP 0.00181 0.40809
197 1JAY NAP 0.007766 0.40809
198 1KOL NAD 0.002138 0.40784
199 4DPL NAP 0.002718 0.40767
200 3L4S NAD 0.001459 0.40731
201 1PGP 6PG 0.00225 0.40702
202 2GZ3 NAP 0.001953 0.40689
203 3OA2 NAD 0.003337 0.40678
204 3CIF NAD 0.0008268 0.40671
205 3CIF NAD 0.0008268 0.40671
206 3CIF NAD 0.0006632 0.40671
207 2VYN NAD 0.0008189 0.40632
208 4R5M 4NO 0.002553 0.40619
209 4KP7 1UQ 0.002745 0.40608
210 1MUU NAD 0.005481 0.40607
211 3T31 FAD 0.006225 0.40597
212 5MDH NAD 0.000856 0.40585
213 1ZQ9 SAM 0.0139 0.4058
214 3FEA ACE PHE MET AIB PM3 6CW GLU 1AC LEU NH2 0.031 0.40549
215 3L4S 3PG 0.001984 0.40538
216 1YKF NAP 0.003145 0.40524
217 1SC6 NAD 0.001717 0.40497
218 3B1J NAD 0.003241 0.40475
219 1ZMD NAI 0.00693 0.40457
220 1M2Z BOG 0.0482 0.40396
221 3NHB ADP 0.0491 0.40393
222 1YKJ FAD 0.009488 0.4036
223 1YKJ PHB 0.009488 0.4036
224 2ZJ1 NAD 5.13e-05 0.40341
225 1G6H ADP 0.04203 0.40331
226 3OND ADN 9.71e-05 0.4028
227 3OND ADN 9.71e-05 0.4028
228 3OND NAD 9.71e-05 0.4028
229 3OND NAD 9.71e-05 0.4028
230 1SAY PYR 0.00257 0.40253
231 3CIF NAD 0.0006958 0.40228
232 3TWO NDP 0.00159 0.40226
233 3NOJ PYR 0.02503 0.40224
234 3NOJ PYR 0.02503 0.40224
235 3CMC NAD 0.01145 0.40221
236 1IE3 NAD 0.002897 0.40173
237 2ZJ1 ARJ 5.583e-05 0.40107
238 4MZU TDR 0.02572 0.4006
239 2O4C NAD 0.001957 0.40033
240 2GCG NDP 0.004303 0.40004
241 3CIF NAD 0.000824 0.40003
Pocket No.: 3; Query (leader) PDB : 1DIG; Ligand: NAP; Similar sites found: 265
This union binding pocket(no: 3) in the query (biounit: 1dig.bio1) has 33 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 4K28 NAD 2.118e-05 0.5075
2 2HJR APR 5.219e-05 0.50025
3 1O0S NAI 6.377e-05 0.49201
4 1V6A TRE 0.001174 0.49172
5 2HJR APR 7.181e-05 0.48984
6 2HJR APR 7.726e-05 0.4885
7 2HJR APR 7.776e-05 0.48838
8 2HJR APR 7.776e-05 0.48838
9 2HJR APR 7.776e-05 0.48838
10 2HJR APR 8.169e-05 0.48748
11 2HJR APR 8.471e-05 0.48682
12 2HJR APR 8.471e-05 0.48682
13 2HJR APR 8.471e-05 0.48682
14 1T26 GBD 3.371e-05 0.48576
15 1T26 NAI 3.371e-05 0.48576
16 4K28 NAD 5.816e-05 0.48516
17 2HJR APR 7.733e-05 0.48423
18 2HJR APR 7.733e-05 0.48423
19 2HJR APR 7.733e-05 0.48423
20 2HJR APR 0.0001044 0.483
21 4J4H NAI 6.504e-05 0.4816
22 4J4H 1J1 6.504e-05 0.4816
23 2CDC XYP 0.0001461 0.48038
24 4J4H 1J1 5.112e-05 0.48004
25 4J4H NAI 5.497e-05 0.48
26 3NJ4 AFX 7.783e-05 0.47959
27 3NJ4 NAD 0.0004629 0.47936
28 4J4H NAI 5.828e-05 0.47902
29 4J4H NAI 6.666e-05 0.47902
30 4J4H 1J1 6.666e-05 0.47902
31 4J4H 1J1 5.605e-05 0.4785
32 2HJR APR 0.0001374 0.47797
33 1UXG NAD 3.987e-05 0.47779
34 1UXG FUM 3.987e-05 0.47779
35 2CDC XYS 0.0001694 0.47778
36 2CDC NAP 0.0001694 0.47778
37 4J4H NAI 6.756e-05 0.47655
38 4R68 W31 0.0001385 0.47544
39 4R68 NAI 0.0001457 0.47544
40 1GQ2 NAP 7.231e-05 0.47352
41 1GQ2 NAP 7.239e-05 0.4735
42 4PLG NAI 4.785e-05 0.47344
43 4PLG OXM 4.785e-05 0.47344
44 1GV0 NAD 1.999e-05 0.47223
45 2A92 NAI 3.419e-05 0.47139
46 4J4H 1J1 8.647e-05 0.47009
47 1EZ4 NAD 0.0001108 0.46995
48 1GQ2 NAP 7.946e-05 0.46824
49 2DT5 NAD 8.689e-05 0.46674
50 1GUZ NAD 2.398e-05 0.46506
51 1SOW NAD 5.128e-05 0.46491
52 4JK3 NAD 1.403e-05 0.46437
53 4JK3 NAD 2.438e-05 0.46437
54 1V8B NAD 7.716e-05 0.46427
55 1GQ2 NAP 0.0001031 0.46387
56 1LDM NAD 8.389e-05 0.4638
57 4JK3 NAD 1.608e-05 0.46268
58 4BVA T3 0.0001025 0.46232
59 4BVA NDP 4.949e-05 0.46185
60 1D1T NAD 8.048e-05 0.46105
61 1U3U BNF 0.0001575 0.46012
62 1U3U NAD 0.0001575 0.46012
63 1D1T NAD 7.397e-05 0.45906
64 1D1T NAD 7.397e-05 0.45906
65 1NYT NAP 0.0002651 0.45838
66 1NYT NAP 0.0002651 0.45838
67 1NYT NAP 0.0002651 0.45838
68 4MP8 NAD 0.0001254 0.45772
69 4MP8 MLI 0.0001254 0.45772
70 2VHW NAI 0.0001162 0.45761
71 2FZW NAD 0.0002359 0.45452
72 2GZ3 NAP 0.0003488 0.45407
73 2GZ3 NAP 0.0003296 0.45407
74 1I0Z NAI 0.0001518 0.45401
75 2DT5 NAD 0.0001814 0.45107
76 2IZ1 ATR 0.006228 0.44919
77 1LLU NAD 7.838e-05 0.44899
78 1NPD NAD 0.0005535 0.44885
79 1P77 ATR 0.006825 0.44751
80 1OMO NAD 2.97e-05 0.44627
81 2F1K NAP 0.0005353 0.44597
82 2IZZ NAD 0.0003649 0.44591
83 3GFB NAD 0.0003739 0.4455
84 3WLE NAD 0.0002518 0.44504
85 1A5Z NAD 0.001036 0.44452
86 1O6Z NAD 3.224e-05 0.44418
87 1X7D ORN 0.0002932 0.44384
88 3B1F NAD 0.001082 0.4437
89 9LDB NAD 0.0002405 0.44328
90 2CVQ NDP 0.000361 0.44285
91 1EBF NAD 4.407e-05 0.44212
92 1C3V NDP 0.0002628 0.44184
93 1VI2 NAD 0.001201 0.44176
94 4GKV NAD 0.0003039 0.43931
95 3JV7 NAD 0.0003763 0.43903
96 1LLU NAD 0.0001546 0.43845
97 4W6Z 8ID 0.0003846 0.43815
98 1HYH NAD 0.0003309 0.4381
99 1HYH NAD 0.0003309 0.4381
100 2QRK AMP 0.0004524 0.43798
101 1HDG NAD 0.0008784 0.43722
102 9LDT NAD 0.0002405 0.43695
103 3ABI NAD 0.0004522 0.43601
104 4RQU NAD 0.0001737 0.43537
105 1LTH NAD 5.7e-05 0.43502
106 3H9E NAD 0.0008411 0.43477
107 1X7D NAD 0.0001886 0.43463
108 3QV1 NAD 0.0008759 0.43407
109 1O94 ADP 0.00135 0.43281
110 1OBB NAD 0.001383 0.43239
111 2F1K NAP 0.001 0.43176
112 1LTH NAD 0.0001638 0.43174
113 1NVM NAD 0.0005114 0.43103
114 3ETG NDP 0.001613 0.43057
115 3VPH NAD 0.0003348 0.43055
116 3ETG GLU 0.001627 0.43042
117 1E3I CXF 0.0001547 0.42975
118 3QV1 NAD 0.00115 0.42933
119 3QV1 NAD 0.00115 0.42933
120 2DFV NAD 0.0002379 0.42894
121 1LDN NAD 0.00041 0.42874
122 1LDN NAD 0.000431 0.42794
123 1VM6 NAD 0.0001457 0.42734
124 1LVL NAD 0.003171 0.42693
125 1CDO NAD 0.0001899 0.42687
126 1PL6 572 0.0006114 0.42671
127 1GR0 NAD 0.0006646 0.4267
128 2DFV NAD 0.0002287 0.42664
129 1J5P NAD 0.001132 0.4266
130 1PZG A3D 0.0001511 0.42635
131 2DFV NAD 0.0002953 0.42568
132 3IP5 ALA 0.01871 0.42553
133 4MDH NAD 0.001223 0.42527
134 1B8U OAA 0.0006188 0.42514
135 3GGO ENO 0.001308 0.4249
136 3GGO NAI 0.001308 0.4249
137 1PL6 572 0.0006289 0.42488
138 1PL6 572 0.0006289 0.42488
139 2YVJ NAI 0.005086 0.42461
140 4W6Z 8ID 0.0008372 0.42426
141 1J0X NAD 0.001637 0.42411
142 1F8F NAD 0.0001674 0.42392
143 1NVM NAD 0.0005117 0.42364
144 1P0F NAP 0.0006976 0.42322
145 1NVT NAP 0.000175 0.42303
146 4KOA NDP 0.006612 0.42288
147 1CER NAD 0.001686 0.4227
148 1BW9 NAD 0.003376 0.42247
149 3ETG GTP 0.001715 0.42237
150 2I3G NAP 0.0009431 0.4211
151 1M2W NAD 0.00308 0.42102
152 1PL6 NAD 0.0001053 0.42057
153 1PL6 NAD 7.9e-05 0.42057
154 2B5W NAP 0.0003882 0.4204
155 2EV9 SKM 0.0008488 0.42009
156 2EV9 NAP 0.0008488 0.42009
157 4E5N NAD 0.0008911 0.41931
158 4LWU 20U 0.01122 0.41918
159 3VPH OXM 0.000405 0.41915
160 1DXY NAD 0.0003368 0.41896
161 1DXY NAD 0.0003368 0.41896
162 1C1X NAD 0.002112 0.41878
163 4E5N NAD 0.0007974 0.41838
164 1PL6 NAD 9.641e-05 0.4181
165 4E5N NAD 0.00101 0.4173
166 2WQ4 SFU 0.03403 0.41715
167 4E5N NAD 0.0008801 0.41686
168 3A06 FOM 0.001484 0.41619
169 3A06 NDP 0.001301 0.41587
170 1J49 NAD 0.0006355 0.41581
171 2I3G NAP 0.001134 0.41546
172 2I3G NAP 0.001134 0.41546
173 3BAZ NAP 0.00301 0.41545
174 1GAD NAD 0.0003978 0.41541
175 4OOE NDP 0.002566 0.4154
176 3CIF G3H 0.001248 0.41525
177 3CIF G3H 0.001352 0.41525
178 3V1Y NAD 0.00259 0.41524
179 3T31 DCQ 0.004703 0.41445
180 4QX6 NAD 0.0001939 0.41436
181 2HK9 NAP 0.0003971 0.41415
182 4KP7 NAP 0.002072 0.41412
183 1H2B NAJ 0.0009766 0.41385
184 2PV7 NAD 0.0024 0.41377
185 3L4S 3PG 0.001371 0.41374
186 2GZ3 NAP 0.001498 0.4136
187 2HK9 NAP 0.0005017 0.41324
188 2VYN NAD 0.0007387 0.41222
189 3CIF NAD 0.0007626 0.41213
190 3CIF NAD 0.0006119 0.41213
191 3CIF NAD 0.0007626 0.41213
192 1PGP 6PG 0.001912 0.41207
193 3L4S NAD 0.00143 0.41175
194 3QV9 QV7 0.03394 0.41169
195 1YQD NAP 0.001162 0.41157
196 4KP7 1UQ 0.002327 0.41113
197 3T31 FAD 0.00525 0.41105
198 5MDH NAD 0.0008057 0.41039
199 1TB4 PEJ 0.00216 0.41019
200 1KOL NAD 0.002203 0.40977
201 1KEV NDP 0.001036 0.4096
202 2GV8 NDP 0.00493 0.40951
203 4R5M NAP 0.002635 0.4095
204 2GCG NDP 0.002665 0.40931
205 1SC6 NAD 0.001703 0.40896
206 3QV1 NAD 0.002747 0.4088
207 1HKU NAD 0.002013 0.40878
208 1JAY NAP 0.00712 0.40852
209 3OA2 NAD 0.002815 0.40839
210 3CMC NAD 0.009305 0.40786
211 3CIF NAD 0.000643 0.40765
212 1YKJ PHB 0.008488 0.40759
213 1YKJ FAD 0.008488 0.40759
214 1SAY PYR 0.002225 0.40721
215 2NAD NAD 0.002478 0.40668
216 4DPL NAP 0.002677 0.40665
217 2GSD NAD 0.002489 0.40661
218 1ZQ9 SAM 0.01282 0.40626
219 4R5M 4NO 0.002361 0.40619
220 1MUU NAD 0.005127 0.40604
221 2B4R NAD 0.001689 0.40603
222 3FEA ACE PHE MET AIB PM3 6CW GLU 1AC LEU NH2 0.02953 0.40549
223 3CIF NAD 0.000762 0.40531
224 1YKF NAP 0.002915 0.40524
225 3B1J NAD 0.003004 0.40475
226 1ZMD NAI 0.006485 0.40457
227 4L8V NAP 0.001607 0.40443
228 2RAB NAD 0.01144 0.4042
229 1YB5 NAP 0.002683 0.40419
230 1YB5 NAP 0.002683 0.40419
231 2B4R AES 0.001556 0.40399
232 1M2Z BOG 0.04646 0.40396
233 3NHB ADP 0.04703 0.40393
234 1DSS NAD 0.0006418 0.40393
235 2HK9 NAP 0.0009145 0.40367
236 2ZJ1 NAD 4.135e-05 0.40339
237 3CGD COA 0.0164 0.40332
238 3CGD FAD 0.0164 0.40332
239 3CGD NAD 0.0164 0.40332
240 1G6H ADP 0.04033 0.40331
241 1UP7 NAD 0.0005777 0.40316
242 3OND ADN 7.991e-05 0.40264
243 3OND ADN 7.991e-05 0.40264
244 3OND NAD 7.991e-05 0.40264
245 3OND NAD 7.991e-05 0.40264
246 3CIF G3H 0.003013 0.40232
247 3CIF G3H 0.003242 0.40232
248 3CIF G3H 0.003242 0.40232
249 3NOJ PYR 0.02404 0.40224
250 3NOJ PYR 0.02404 0.40224
251 2ZB4 5OP 0.004047 0.40204
252 4EDF UPG 0.006762 0.40195
253 3TWO NDP 0.001411 0.40169
254 1K3T BRZ 0.002983 0.40126
255 3GGO ENO 0.005126 0.40119
256 3GGO NAI 0.005126 0.40119
257 1GET NAP 0.01457 0.40108
258 2ZJ1 ARJ 4.495e-05 0.40107
259 3GD4 NAD 0.01706 0.40103
260 3GD4 NAD 0.01706 0.40103
261 2ZB4 NAP 0.004136 0.40061
262 4MZU TDR 0.0247 0.4006
263 1B8U NAD 0.0004061 0.40045
264 2YVF FAD 0.01211 0.40004
265 2YVF NAD 0.01257 0.40004
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