Receptor
PDB id Resolution Class Description Source Keywords
1AWI 2.2 Å NON-ENZYME: MOBILE HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE HOMO SAPIENS PROFILIN POLY-L-PROLINE ACTIN CYTOSKELETON COMPLEX (ACTIN-BINDING PROTEIN/PEPTIDE)
Ref.: STRUCTURE OF THE PROFILIN-POLY-L-PROLINE COMPLEX INVOLVED IN MORPHOGENESIS AND CYTOSKELETAL REGULATION. NAT.STRUCT.BIOL. V. 4 953 1997
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO P:1;
Valid;
none;
Kd = 90 uM
989.185 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1AWI 2.2 Å NON-ENZYME: MOBILE HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE HOMO SAPIENS PROFILIN POLY-L-PROLINE ACTIN CYTOSKELETON COMPLEX (ACTIN-BINDING PROTEIN/PEPTIDE)
Ref.: STRUCTURE OF THE PROFILIN-POLY-L-PROLINE COMPLEX INVOLVED IN MORPHOGENESIS AND CYTOSKELETAL REGULATION. NAT.STRUCT.BIOL. V. 4 953 1997
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 61 families.
1 1AWI Kd = 90 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 1CF0 - PRO PRO PRO PRO PRO PRO PRO PRO IYR n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 1AWI Kd = 90 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 1CF0 - PRO PRO PRO PRO PRO PRO PRO PRO IYR n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 39 families.
1 1AWI Kd = 90 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 1CF0 - PRO PRO PRO PRO PRO PRO PRO PRO IYR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO; Similar ligands found: 11
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1AWI; Ligand: PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO; Similar sites found: 12
This union binding pocket(no: 1) in the query (biounit: 1awi.bio1) has 18 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5URY PAM 0.002939 0.45192 None
2 3KO0 TFP 0.01565 0.41785 None
3 3RV5 DXC 0.008688 0.41566 None
4 5UGW GSH 0.02681 0.41423 None
5 3O01 DXC 0.01049 0.4406 2.17391
6 2QES ADE 0.01045 0.42252 2.89855
7 4IKZ AFS 0.01412 0.40084 5.7971
8 1ECM TSA 0.01289 0.40481 7.33945
9 4IN9 SER TRP PHE PRO 0.01399 0.41078 8.69565
10 4QGE 35O 0.00004684 0.4801 9.42029
11 5C1M OLC 0.01414 0.4242 9.42029
12 2YFB SIN 0.01959 0.42053 9.42029
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