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Receptor
PDB id Resolution Class Description Source Keywords
1AWI 2.2 Å NON-ENZYME: MOBILE HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE HOMO SAPIENS PROFILIN POLY-L-PROLINE ACTIN CYTOSKELETON COMPLEX (ACTIN-BINDING PROTEIN/PEPTIDE)
Ref.: STRUCTURE OF THE PROFILIN-POLY-L-PROLINE COMPLEX INVOLVED IN MORPHOGENESIS AND CYTOSKELETAL REGULATION. NAT.STRUCT.BIOL. V. 4 953 1997
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO P:1;
Valid;
none;
Kd = 90 uM
989.185 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1AWI 2.2 Å NON-ENZYME: MOBILE HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE HOMO SAPIENS PROFILIN POLY-L-PROLINE ACTIN CYTOSKELETON COMPLEX (ACTIN-BINDING PROTEIN/PEPTIDE)
Ref.: STRUCTURE OF THE PROFILIN-POLY-L-PROLINE COMPLEX INVOLVED IN MORPHOGENESIS AND CYTOSKELETAL REGULATION. NAT.STRUCT.BIOL. V. 4 953 1997
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 65 families.
1 1AWI Kd = 90 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 1CF0 - PRO PRO PRO PRO PRO PRO PRO PRO IYR n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 56 families.
1 1AWI Kd = 90 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 1CF0 - PRO PRO PRO PRO PRO PRO PRO PRO IYR n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 39 families.
1 1AWI Kd = 90 uM PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 1CF0 - PRO PRO PRO PRO PRO PRO PRO PRO IYR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO; Similar ligands found: 14
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1AWI; Ligand: PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO; Similar sites found with APoc: 28
This union binding pocket(no: 1) in the query (biounit: 1awi.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5URY PAM None
2 3KO0 TFP None
3 3RV5 DXC None
4 5UGW GSH None
5 4PGK Y69 None
6 3N8K D1X None
7 3O01 DXC 2.17391
8 5Z3I ADE 2.17391
9 2QES ADE 2.89855
10 5FFF NAP 3.62319
11 5UR1 YY9 3.62319
12 5HCY 60D 3.62319
13 5FFF 5XC 3.62319
14 3NB0 G6P 4.34783
15 3G5D 1N1 5.07246
16 2D5X L35 5.7971
17 4IKZ AFS 5.7971
18 1ECM TSA 7.33945
19 6C0B PAM 8.69565
20 4IN9 SER TRP PHE PRO 8.69565
21 5C1M OLC 9.42029
22 2YFB SIN 9.42029
23 2AE2 PTO 10.1449
24 5LX9 OLB 11.5942
25 5LWY OLB 13.4454
26 4J7Q B7N 13.7681
27 5OJI ISN 17.3913
28 5OJI NAP 17.3913
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