Receptor
PDB id Resolution Class Description Source Keywords
1BL5 2.5 Å EC: 1.1.1.42 ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE S OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION ESCHERICHIA COLI OXIDOREDUCTASE NAD(A)-CHOH(D) PHOSPHORYLATION
Ref.: MILLISECOND LAUE STRUCTURES OF AN ENZYME-PRODUCT CO USING PHOTOCAGED SUBSTRATE ANALOGS. NAT.STRUCT.BIOL. V. 5 891 1998
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AKG A:1;
Valid;
none;
submit data
146.098 C5 H6 O5 C(CC(...
MG A:418;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
NAP A:2;
Valid;
Atoms found LESS than expected: % Diff = 0;
submit data
743.405 C21 H28 N7 O17 P3 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1GRO 2.5 Å EC: 1.1.1.42 REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOC DEHYDROGENASE: MULTIPLE ROLES FOR N115 ESCHERICHIA COLI OXIDOREDUCTASE NADP PHOSPHORYLATION GLYOXYLATE BYPASS OXIDOREDUCTASE (NAD(A)-CHOH(D))
Ref.: SECOND-SITE SUPPRESSION OF REGULATORY PHOSPHORYLATI ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE. PROTEIN SCI. V. 5 287 1996
Members (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 9ICD Kd = 125 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
2 4AJ3 - ICT C6 H8 O7 C([C@@H]([....
3 1PB1 - ICT C6 H8 O7 C([C@@H]([....
4 5ICD - ICT C6 H8 O7 C([C@@H]([....
5 4AJA - ICT C6 H8 O7 C([C@@H]([....
6 1AI3 Ki = 403 uM NDO C21 H27 N6 O18 P3 c1cc(c[n+]....
7 1ISO - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
8 1P8F - ICT C6 H8 O7 C([C@@H]([....
9 4AJB - TAP C21 H28 N7 O16 P3 S c1cc(c[n+]....
10 1CW4 - AKG C5 H6 O5 C(CC(=O)O)....
11 4BNP Ki = 96 uM ICT C6 H8 O7 C([C@@H]([....
12 1CW1 - ICT C6 H8 O7 C([C@@H]([....
13 1GRO Ki = 0.033 uM ICT C6 H8 O7 C([C@@H]([....
14 1IDE - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 4AJC - AKG C5 H6 O5 C(CC(=O)O)....
16 4AJS - ICT C6 H8 O7 C([C@@H]([....
17 1HJ6 - IPM C7 H12 O5 CC(C)[C@@H....
18 1BL5 - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 1AI2 Ki = 2.7 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
20 1GRP Ki = 0.189 mM ICT C6 H8 O7 C([C@@H]([....
21 8ICD - ICT C6 H8 O7 C([C@@H]([....
70% Homology Family (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 9ICD Kd = 125 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
2 4AJ3 - ICT C6 H8 O7 C([C@@H]([....
3 1PB1 - ICT C6 H8 O7 C([C@@H]([....
4 5ICD - ICT C6 H8 O7 C([C@@H]([....
5 4AJA - ICT C6 H8 O7 C([C@@H]([....
6 1AI3 Ki = 403 uM NDO C21 H27 N6 O18 P3 c1cc(c[n+]....
7 1ISO - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
8 1P8F - ICT C6 H8 O7 C([C@@H]([....
9 4AJB - TAP C21 H28 N7 O16 P3 S c1cc(c[n+]....
10 1CW4 - AKG C5 H6 O5 C(CC(=O)O)....
11 4BNP Ki = 96 uM ICT C6 H8 O7 C([C@@H]([....
12 1CW1 - ICT C6 H8 O7 C([C@@H]([....
13 1GRO Ki = 0.033 uM ICT C6 H8 O7 C([C@@H]([....
14 1IDE - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 4AJC - AKG C5 H6 O5 C(CC(=O)O)....
16 4AJS - ICT C6 H8 O7 C([C@@H]([....
17 1HJ6 - IPM C7 H12 O5 CC(C)[C@@H....
18 1BL5 - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 1AI2 Ki = 2.7 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
20 1GRP Ki = 0.189 mM ICT C6 H8 O7 C([C@@H]([....
21 8ICD - ICT C6 H8 O7 C([C@@H]([....
22 1HQS - CIT C6 H8 O7 C(C(=O)O)C....
23 2D4V - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
50% Homology Family (25)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 9ICD Kd = 125 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
2 4AJ3 - ICT C6 H8 O7 C([C@@H]([....
3 1PB1 - ICT C6 H8 O7 C([C@@H]([....
4 5ICD - ICT C6 H8 O7 C([C@@H]([....
5 4AJA - ICT C6 H8 O7 C([C@@H]([....
6 1AI3 Ki = 403 uM NDO C21 H27 N6 O18 P3 c1cc(c[n+]....
7 1ISO - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
8 1P8F - ICT C6 H8 O7 C([C@@H]([....
9 4AJB - TAP C21 H28 N7 O16 P3 S c1cc(c[n+]....
10 1CW4 - AKG C5 H6 O5 C(CC(=O)O)....
11 4BNP Ki = 96 uM ICT C6 H8 O7 C([C@@H]([....
12 1CW1 - ICT C6 H8 O7 C([C@@H]([....
13 1GRO Ki = 0.033 uM ICT C6 H8 O7 C([C@@H]([....
14 1IDE - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 4AJC - AKG C5 H6 O5 C(CC(=O)O)....
16 4AJS - ICT C6 H8 O7 C([C@@H]([....
17 1HJ6 - IPM C7 H12 O5 CC(C)[C@@H....
18 1BL5 - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 1AI2 Ki = 2.7 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
20 1GRP Ki = 0.189 mM ICT C6 H8 O7 C([C@@H]([....
21 8ICD - ICT C6 H8 O7 C([C@@H]([....
22 1HQS - CIT C6 H8 O7 C(C(=O)O)C....
23 2D4V - NAD C21 H27 N7 O14 P2 c1cc(c[n+]....
24 1XKD - ICT C6 H8 O7 C([C@@H]([....
25 1TYO - ENP C17 H24 N5 O17 P3 c1cn2cnc3c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AKG; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 AKG 1 1
2 SIN 0.526316 0.833333
3 SHF 0.416667 0.666667
4 3PY 0.409091 0.652174
Ligand no: 2; Ligand: NAP; Similar ligands found: 114
No: Ligand ECFP6 Tc MDL keys Tc
1 NAP 1 1
2 NA0 0.881356 0.986301
3 TAP 0.872881 0.934211
4 NDO 0.840336 0.972603
5 NAD 0.811966 0.986111
6 N01 0.733871 0.958904
7 A3D 0.712 0.972603
8 NBP 0.707692 0.935065
9 NAD IBO 0.688 0.921053
10 NHD 0.68254 0.958904
11 NJP 0.661417 0.972973
12 NAJ PYZ 0.659091 0.898734
13 NFD 0.658915 0.934211
14 DND 0.619048 0.959459
15 NXX 0.619048 0.959459
16 ZID 0.605839 0.972603
17 NAQ 0.59854 0.922078
18 ATR 0.59292 0.917808
19 NAE 0.591241 0.946667
20 NDE 0.58042 0.986301
21 A22 0.571429 0.958904
22 AMP NAD 0.571429 0.933333
23 NAJ 0.567164 0.986111
24 A2R 0.563025 0.932432
25 NDC 0.561644 0.922078
26 NA7 0.552846 0.907895
27 ODP 0.551471 0.935065
28 A2P 0.539823 0.930556
29 8ID 0.537313 0.910256
30 NPW 0.525547 0.8875
31 NZQ 0.521739 0.910256
32 CNA 0.521739 0.959459
33 NDP 0.514493 0.922078
34 PO4 PO4 A A A A PO4 0.503937 0.930556
35 1DG 0.503401 0.922078
36 DG1 0.503401 0.922078
37 NAD TDB 0.5 0.696078
38 TXP 0.5 0.922078
39 NMN AMP PO4 0.492958 0.921053
40 25L 0.492308 0.958904
41 25A 0.492063 0.972222
42 NAD NDT 0.490909 0.747368
43 NMN 0.486726 0.888889
44 NGD 0.485714 0.935065
45 2AM 0.477876 0.891892
46 ADP 0.458333 0.945205
47 PAP 0.451613 0.931507
48 ADP MG 0.45082 0.906667
49 ADP BEF 0.447154 0.883117
50 BEF ADP 0.447154 0.883117
51 A2D 0.445378 0.945205
52 SAP 0.44 0.896104
53 AGS 0.44 0.896104
54 ADP PO3 0.44 0.944444
55 M33 0.439024 0.906667
56 AR6 AR6 0.438849 0.945205
57 BA3 0.438017 0.945205
58 ATP MG 0.436508 0.906667
59 ADP BMA 0.43609 0.92
60 OAD 0.43609 0.92
61 ATP 0.435484 0.945205
62 B4P 0.434426 0.945205
63 AP5 0.434426 0.945205
64 GAP 0.433071 0.92
65 0WD 0.432432 0.922078
66 2A5 0.432 0.87013
67 5FA 0.432 0.945205
68 AQP 0.432 0.945205
69 00A 0.428571 0.909091
70 CA0 0.427419 0.92
71 ADP ALF 0.426357 0.871795
72 ALF ADP 0.426357 0.871795
73 ACP 0.424 0.92
74 NAJ PZO 0.423841 0.897436
75 ADP VO4 0.423077 0.932432
76 ANP MG 0.423077 0.896104
77 V3L 0.421875 0.945205
78 ACQ 0.421875 0.92
79 ADQ 0.421053 0.92
80 APR 0.420635 0.918919
81 AR6 0.420635 0.918919
82 ATP A A A 0.42029 0.958333
83 CO7 0.419753 0.786517
84 1ZZ 0.419118 0.841463
85 3OD 0.419118 0.92
86 DLL 0.41791 0.958904
87 AD9 0.417323 0.92
88 OVE 0.416667 0.857143
89 NAX 0.416667 0.875
90 MYR AMP 0.416058 0.841463
91 AV2 0.415385 0.868421
92 A3P 0.414634 0.944444
93 NNR 0.414414 0.72973
94 ALF ADP 3PG 0.413793 0.8625
95 LA8 ALF 3PG 0.413793 0.8625
96 ANP 0.410853 0.92
97 A1R 0.410448 0.860759
98 ABM 0.409836 0.893333
99 A 0.408333 0.944444
100 AMP 0.408333 0.944444
101 SON 0.408 0.933333
102 5AL 0.407692 0.932432
103 PPS 0.407692 0.829268
104 NAI 0.406897 0.909091
105 DAL AMP 0.406015 0.932432
106 ADX 0.404762 0.829268
107 ATF 0.40458 0.907895
108 AMP DBH 0.404255 0.894737
109 139 0.402685 0.875
110 AMP MG 0.401639 0.893333
111 50T 0.401575 0.906667
112 SRP 0.401515 0.907895
113 3AM 0.4 0.90411
114 FA5 0.4 0.933333
Similar Binding Sites
Pocket no: 1; Query (leader) PDB : 1GRO; Ligand: ICT; Similar sites found: 549
This union binding pocket (no: 1) in the query (biounit: 1gro.bio1) has 45 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc)
1 1GRO ICT 2.503e-30 1
2 1HEX NAD 5.121e-11 0.49158
3 4MZ7 DTP 0.03406 0.36636
4 2F01 BTQ 0.01975 0.36207
5 4KGD TDP 0.01779 0.36096
6 4NAT 2W5 0.01898 0.35964
7 2QA1 FAD 0.002827 0.34581
8 1RM0 NAI 0.02554 0.34473
9 3OND NAD 0.02021 0.34415
10 3WE0 FAD 0.01084 0.34356
11 4LH5 LF0 0.04126 0.34196
12 1RM4 NDP 0.04426 0.34048
13 2I7C AAT 0.005041 0.3397
14 1HDR NAD 0.002374 0.3389
15 2YC5 6BC 0.005684 0.33883
16 2BKA NDP 0.002196 0.33859
17 1GEE NAD 0.002601 0.3374
18 1G0N NDP 0.01511 0.33583
19 2AQJ FAD 0.01561 0.33524
20 4MP8 MLI 0.01047 0.33507
21 1UXG FUM 0.02476 0.33484
22 3KO8 NAD 0.008918 0.33333
23 3ZV6 NAD 0.0456 0.33094
24 2YHW BM3 0.005052 0.32972
25 1JQI FAD 0.008064 0.32909
26 9LDB NAD 0.009071 0.32874
27 1SOW NAD 0.006889 0.32854
28 1UNB AKG 0.0321 0.3283
29 2GSD NAD 0.007567 0.32784
30 3U4C NDP 0.008804 0.32775
31 4P53 NAI 0.004413 0.32707
32 1REO FAD 0.03367 0.32687
33 3B96 FAD 0.01245 0.32679
34 3Q9T FAY 0.03906 0.32586
35 3D3W NAP 0.02771 0.32583
36 2NP9 YE1 0.01731 0.32578
37 4B8V NDG 0.0058 0.32578
38 2Q2V NAD 0.01844 0.3255
39 4PLG NAI 0.02816 0.32549
40 1CSI CMX 0.02533 0.32511
41 2PT9 2MH 0.02123 0.32494
42 1YOE RIB 0.02147 0.32424
43 1RKD ADP 0.03019 0.32423
44 2B5W NAP 0.0305 0.32422
45 1NN5 ANP 0.01367 0.32412
46 2C7G FAD 0.03273 0.32329
47 1G79 FMN 0.02499 0.32323
48 1GAD NAD 0.006419 0.32234
49 2DWO ADP 0.02441 0.32216
50 2E2R 2OH 0.01789 0.32073
51 2AHR NAP 0.01327 0.32041
52 1A27 NAP 0.01962 0.31997
53 9LDT NAD 0.01064 0.31964
54 3QUR ADP 0.01627 0.31827
55 4DL8 UMP 0.002974 0.31827
56 1RHC F42 0.01541 0.31795
57 1VE3 SAM 0.003303 0.31782
58 4NDA NIY 0.001346 0.31765
59 3BK2 U5P 0.0236 0.31742
60 1O9D GLN 0.01402 0.31654
61 9LDB OXM 0.02704 0.31646
62 4KQI NIO 0.01678 0.31599
63 1UJ2 C5P 0.01548 0.31586
64 4C0X AQN 0.02153 0.3156
65 3GE7 AFQ 0.02422 0.31545
66 3PJU C2E 0.006574 0.31517
67 2VEZ ACO 0.03725 0.31474
68 1WVG APR 0.009972 0.31457
69 3RO7 TDR 0.01661 0.31385
70 3I51 45C 0.008696 0.31332
71 1I52 CTP 0.03464 0.31331
72 1EP2 FMN 0.0294 0.3131
73 2HV8 GTP 0.01146 0.31262
74 1TOX NAD 0.006109 0.31249
75 3P0K FAD 0.0105 0.31245
76 1R37 NAD 0.04284 0.31243
77 2GDZ NAD 0.04642 0.31217
78 2D2I NAP 0.01302 0.31161
79 4C58 824 0.0006968 0.31097
80 1B4P GPS 0.04318 0.31093
81 3ULK NDP 0.01317 0.31084
82 1HDG NAD 0.01568 0.31056
83 2IZZ NAD 0.0234 0.31046
84 4L1F COS 0.001229 0.31033
85 1M7Y PPG 0.01689 0.31019
86 4OB6 S2T 0.04841 0.30934
87 1Z45 NAD 0.03646 0.30913
88 4JDC NAD 0.02658 0.30913
89 3BW2 FMN 0.03966 0.30855
90 3DAG FEG 0.02284 0.30854
91 2VBQ BSJ 0.04566 0.30848
92 3MBG FAD 0.006325 0.30848
93 1B8U NAD 0.04155 0.30835
94 2QFY AKG 0.0001352 0.30827
95 2Z9C DTC 0.0177 0.30814
96 1SNY NAP 0.02747 0.30805
97 3CF6 SP1 0.02235 0.30763
98 1RBO CAP 0.02323 0.30742
99 2XK9 XK9 0.03369 0.3073
100 1C3V NDP 0.03809 0.30724
101 2J8Z NAP 0.03665 0.30719
102 1KBJ FMN 0.01727 0.30708
103 1KBI FMN 0.02562 0.30663
104 1B9I PXG 0.01588 0.30646
105 1O0S NAI 0.009531 0.30597
106 2J7T 274 0.02411 0.3057
107 1J5P NAD 0.02041 0.30555
108 4FFS BIG 0.02935 0.30553
109 1TOI HCI 0.02958 0.30543
110 4D02 FMN 0.01327 0.30522
111 2BR9 ARG 0.001043 0.30503
112 2WMO GTP 0.004323 0.30479
113 1KDK DHT 0.01253 0.30475
114 1GEX PLP 0.01382 0.30472
115 3VPD ANP 0.009861 0.30461
116 3CKJ CIT 0.02997 0.30453
117 4Q3S X7A 0.03436 0.30441
118 2AG8 NAP 0.009835 0.30433
119 1NZY BCA 0.02028 0.30394
120 4BMO FMN 0.02349 0.30378
121 1EJE FMN 0.01639 0.30376
122 4IOK ADP 0.02532 0.30375
123 1POC GEL 0.01507 0.30371
124 4HR0 PLM 0.0188 0.3037
125 2EFJ SAH 0.00626 0.3036
126 1JQI CAA 0.01729 0.30335
127 4J7H TLO 0.01327 0.3033
128 1DSS NAD 0.04209 0.30328
129 3MCT SAH 0.02006 0.3032
130 1MXI SAH 0.01094 0.30313
131 2ORV 4TA 0.02293 0.3031
132 4OJ8 AKG 0.006707 0.30288
133 1VJT NAD 0.005017 0.30281
134 1FP2 HMO 0.0293 0.30277
135 1B55 4IP 0.001466 0.30269
136 4UMX NAP 0.004552 0.3024
137 4B4D FAD 0.01505 0.30214
138 2HGS ADP 0.01988 0.30208
139 2VLH PM9 0.01235 0.30195
140 3O55 FAD 0.02727 0.30184
141 4M3B 2B2 0.0249 0.30179
142 1LL2 UPG 0.01168 0.3017
143 1I0Z NAI 0.04808 0.30162
144 4IU0 ABH 0.02756 0.3016
145 1KBI PYR 0.0282 0.30155
146 2Q28 ADP 0.01423 0.30145
147 2RL1 UD1 0.0204 0.30133
148 1CX9 NHP 0.03335 0.30131
149 4AIG FLX 0.0018 0.30115
150 1WDA BAG 0.001089 0.30111
151 3BAZ NAP 0.02971 0.30108
152 4PNI KQQ 0.04281 0.30106
153 2IMF TOM 0.04431 0.30103
154 4BG1 OGA 0.00518 0.30083
155 1CTU ZEB 0.0147 0.30067
156 1ECC PCP 0.04012 0.30048
157 3B1F NAD 0.01499 0.30042
158 1DUC DUD 0.02329 0.30033
159 1GV0 NAD 0.04528 0.30024
160 2QF7 AGS 0.004532 0.30019
161 2A0S BIO 0.04298 0.30015
162 1VPM COA 0.04552 0.30013
163 1HYE NAP 0.03895 0.29992
164 4PTZ FMN 0.02111 0.2998
165 1VPT SAM 0.01695 0.29971
166 2BII MTV 0.04754 0.29969
167 1X54 4AD 0.03055 0.29961
168 2VMQ PLP 0.04563 0.29934
169 1B63 ANP 0.02482 0.29919
170 3FKQ ATP 0.007352 0.29896
171 1L8N GCW 0.02077 0.29873
172 2JL1 NAP 0.02265 0.2987
173 2YNM ADP 0.01431 0.29857
174 1EP2 FAD 0.02908 0.2982
175 4AQL TXC 0.008096 0.29819
176 4I71 AGV 0.03226 0.29796
177 1X92 M7P 0.003071 0.29772
178 4F4S EFO 0.04676 0.29763
179 1P9B IMO 0.01978 0.29736
180 3U5S FAD 0.01114 0.29725
181 4M37 SAH 0.04766 0.29699
182 4E13 NAD 0.04048 0.29686
183 1VBI NAD 0.04648 0.29677
184 1T57 FMN 0.03939 0.2967
185 2Z1U ATP 0.01605 0.29658
186 1I2L DCS 0.02845 0.29651
187 3ZS7 ATP 0.03275 0.2963
188 1F7K UMP 0.03873 0.29621
189 5FIV 3TL 0.01284 0.29608
190 4M5P FMN 0.02724 0.29573
191 1GSL FUC 0.008647 0.29571
192 2F5T MAL 0.02159 0.29568
193 4LFL TG6 0.003067 0.29564
194 2VQ5 HBA 0.00527 0.29558
195 3B20 NAD 0.04245 0.29546
196 1EB9 HBA 0.006425 0.29545
197 2J0W ADP 0.01928 0.29543
198 2Y7G AAE 0.008462 0.29541
199 3LST SAH 0.00731 0.29535
200 3A2B PLP 0.04081 0.29515
201 2YP9 SIA 0.02851 0.29511
202 2QQF A1R 0.0228 0.29509
203 1MK1 APR 0.02128 0.29493
204 1H9A NAP 0.01151 0.29485
205 3K3G MMU 0.03476 0.2948
206 2D0V PQQ 0.03186 0.2948
207 3FC2 IBI 0.002667 0.29473
208 3QXG TLA 0.03663 0.29435
209 3F3E LEU 0.002915 0.29429
210 6FIV 3TL 0.01414 0.29407
211 2HW1 ANP 0.02516 0.29401
212 2FFC U5P 0.02081 0.29399
213 4WNB 4BN 0.03318 0.29391
214 2YPO PHE 0.04622 0.29385
215 2UZ2 BTN 0.02467 0.2935
216 1WVG CXY 0.03847 0.29335
217 2FYU FDN 0.0178 0.29335
218 3GX0 GDS 0.01047 0.29331
219 3PNL ADP 0.04864 0.2933
220 1AUX AGS 0.009907 0.2932
221 1G6O ADP 0.02934 0.29308
222 2RHQ GAX 0.008839 0.29297
223 4QDC ASD 0.03936 0.29289
224 2NW9 FT6 0.0483 0.29287
225 4NES UD1 0.02499 0.29278
226 3UH0 TSB 0.03359 0.29268
227 1JIL 485 0.02424 0.29257
228 4KOA NDP 0.01036 0.29246
229 2Q8M AMP 0.002248 0.29232
230 1F74 NAY 0.01023 0.29231
231 2HGS GSH 0.01894 0.29227
232 3WJP ANP 0.04538 0.29221
233 1Y52 BTN 0.03284 0.2921
234 2HVW DDN 0.008839 0.29205
235 2P4T NAP 0.02398 0.29198
236 4ARF IP8 0.007204 0.29195
237 4M2K PLP 0.004447 0.29195
238 3I8P 840 0.03948 0.29134
239 1FW1 GSH 0.02022 0.29109
240 1L1Q 9DA 0.0227 0.29104
241 1K6M AGS 0.01883 0.29103
242 4F2O QUS 0.005072 0.29087
243 3JQ3 ADP 0.012 0.29084
244 3GL6 ALA 0.01628 0.29066
245 2IYG FMN 0.0204 0.29055
246 3QXC ATP 0.03658 0.29037
247 4DEC UDP 0.003087 0.29035
248 1AX2 NDG 0.004298 0.29033
249 2D4V NAD 0.001306 0.29017
250 2VAR ANP 0.03332 0.29016
251 4G4S LDZ 0.005711 0.29015
252 3O7B SAH 0.02931 0.28999
253 1W7J ADP 0.03179 0.28988
254 4ME6 ADP 0.004277 0.2897
255 3UIE ANP 0.006118 0.28966
256 2WUF KEM 0.0157 0.28964
257 1EYE PMM 0.02036 0.28951
258 1A59 COA 0.01669 0.28939
259 3LM9 ADP 0.00124 0.28939
260 1H65 GDP 0.04971 0.28932
261 1V2X SAM 0.01209 0.28915
262 3MTW M3R 0.02162 0.28902
263 4P4T GDP 0.03247 0.28901
264 3C9E BDP 0.002323 0.28901
265 1TFZ 869 0.02492 0.28895
266 2QCX PF1 0.0004187 0.28891
267 1FDJ 13P 0.008357 0.28882
268 2WA4 069 0.04824 0.28865
269 2PTZ PAH 0.01472 0.28861
270 2F2U M77 0.01288 0.28808
271 4IMG NGF 0.02203 0.28785
272 3ZF8 GDP 0.01116 0.28784
273 3CBG SAH 0.03119 0.2877
274 3EE4 MYR 0.008622 0.28746
275 2PVQ GSH 0.0208 0.28737
276 4HZO COA 0.006844 0.28706
277 3V1V GST 0.03537 0.28695
278 3RSR N5P 0.01238 0.28692
279 2QF7 COA 0.003207 0.28688
280 2CE7 ADP 0.008474 0.28658
281 1AUA BOG 0.01833 0.2865
282 1UWZ THU 0.01679 0.28625
283 2VPR TDC 0.02448 0.28617
284 2JBH 5GP 0.02572 0.28616
285 2J51 DKI 0.01939 0.28612
286 4IS0 1R4 0.0002131 0.28595
287 4LNL 2BK 0.024 0.28587
288 4LNL 2BO 0.024 0.28587
289 1GVF PGH 0.007081 0.28587
290 3W54 RNB 0.02293 0.28578
291 4B9E FAH 0.03457 0.28562
292 1UOU CMU 0.01481 0.28562
293 1FMB HYB 0.02096 0.28555
294 3QP6 HL6 0.008264 0.28544
295 4IS0 GDS 0.005705 0.28523
296 4A6D SAM 0.02536 0.28514
297 2AQJ TRP 0.02885 0.28511
298 4AMV F6R 0.01207 0.2851
299 1FDJ 2FP 0.03683 0.28509
300 1UAY ADN 0.01837 0.28504
301 1NXJ TLA 0.0404 0.28496
302 2VAR AMP 0.007361 0.28495
303 2TPL HPP 0.03398 0.28488
304 1Y8O ADP 0.0077 0.28482
305 3FED BIX 0.03811 0.28463
306 1MOQ GLP 0.02717 0.28446
307 3UST FAD 0.04461 0.28442
308 1E5F PLP 0.02179 0.28438
309 2D5X L35 9.89e-05 0.28429
310 4JA8 NDP 0.004741 0.28424
311 3KJI ADP 0.0384 0.28383
312 2O2C G6Q 0.01214 0.28379
313 4LMB CYS 0.03282 0.28371
314 2OZE AGS 0.02195 0.28369
315 3ACC 5GP 0.01719 0.28368
316 4BCS BTN 0.04204 0.28352
317 1H2M OGA 0.002121 0.28332
318 2YGN PCF 0.02723 0.28321
319 2Q8M FBP 0.02869 0.28317
320 3HT5 PMP 0.02054 0.28314
321 3JDW ORN 0.008656 0.28243
322 2ZJ3 G6P 0.0405 0.28233
323 2C81 PMP 0.04788 0.28231
324 1XKD NAP 0.0002466 0.2821
325 1ZGA HMK 0.0237 0.28208
326 1KTC NGA 0.01604 0.28208
327 3H22 B53 0.03599 0.28206
328 3UEC ALA 0.004333 0.282
329 1Y2W NAG 0.01073 0.28189
330 1WHT BZS 0.01021 0.28178
331 1KC7 PPR 0.002387 0.28165
332 3IB8 AMP 0.008818 0.28156
333 1OIK AKG 0.02187 0.2813
334 2WM1 13P 0.01418 0.28126
335 4NES UDP 0.04795 0.28118
336 1V03 BGC 0.007572 0.28117
337 3MD0 GDP 0.008916 0.28105
338 4USS GSH 0.00244 0.2807
339 1ZGA SAH 0.008927 0.28054
340 2ZSC BTN 0.0358 0.28053
341 1C7S CBS 0.0291 0.28031
342 3DX5 DHB 0.007103 0.28022
343 4G10 GSH 0.009879 0.28021
344 3BS8 PMP 0.01523 0.2801
345 4WX0 HXD 0.04113 0.27971
346 1R5A GTS 0.01497 0.27964
347 2Y0I AKG 0.0127 0.27955
348 3T2W BTN 0.02757 0.27951
349 1FBL HTA 0.01208 0.27936
350 3WCS MAN 0.03362 0.27933
351 1I1Q TRP 0.04824 0.27931
352 1B5E DCM 0.01171 0.27922
353 3OZG SSI 0.03789 0.27906
354 1UW1 ADP 0.007124 0.27897
355 1NF8 ISC 0.01775 0.27886
356 1NHK CMP 0.0437 0.27886
357 3P3N AKG 0.01191 0.27883
358 4G28 0W8 0.03051 0.27876
359 1QB7 ADE 0.02492 0.27874
360 3KT7 AKG 0.002508 0.27866
361 2VAR KDF 0.04578 0.27848
362 2VAR KDG 0.04578 0.27848
363 2YCJ C2F 0.04219 0.27845
364 2NVK NAP 0.01426 0.27818
365 4E28 9MZ 0.002362 0.27805
366 2NCD ADP 0.003679 0.27792
367 3DG6 MUC 0.02023 0.27786
368 2XUM OGA 0.01563 0.27781
369 4Q3F TLA 0.01638 0.27746
370 4JEJ 1GP 0.02419 0.27736
371 2HVW DCP 0.02923 0.27734
372 2YDW WSH 0.0463 0.27717
373 4B7E OGA 0.01188 0.27672
374 3NFZ 3NF 0.01334 0.27665
375 1NNS ASP 0.01694 0.27642
376 1ECM TSA 0.02005 0.27637
377 2IUW AKG 0.01534 0.27636
378 2JAR UMP 0.04945 0.27587
379 1JK4 CYS 0.02227 0.27571
380 3E9K 3XH 0.01749 0.27562
381 5CSM TRP 0.01152 0.27541
382 2G36 TRP 0.01307 0.27533
383 4C2G ALA 0.00267 0.27514
384 2VWT PYR 0.0007066 0.27513
385 1D2S DHT 0.01717 0.27513
386 4JP3 CIT 0.02395 0.275
387 4KCT FDP 0.04661 0.27499
388 4CCN OGA 0.006998 0.27441
389 4DEW LU2 0.02514 0.2744
390 3RGG AIR 0.02235 0.27435
391 1HQL GLA 0.004419 0.27414
392 2V5E SCR 0.0003417 0.27397
393 3QV9 QV7 0.01404 0.27371
394 3ZTV ADN 0.007959 0.27369
395 2C5S AMP 0.01824 0.27356
396 4BT5 23B 0.02183 0.27319
397 3OCZ SRA 0.01355 0.2731
398 4IHQ ADP 0.004793 0.27309
399 3VKX T3 0.04533 0.27297
400 2NZU BG6 0.01304 0.27295
401 1GU3 BGC 0.04871 0.27282
402 1Z45 GAL 0.01169 0.27276
403 3WCS MAN 0.01195 0.27262
404 2ZE3 AKG 0.02439 0.27248
405 1NH8 AMP 0.0009704 0.27243
406 4M5P 23W 0.02395 0.27243
407 3E4O SIN 0.03772 0.27238
408 1G8S MET 0.0025 0.27224
409 4NPT 017 0.02098 0.27222
410 2WCV FUC 0.0263 0.27217
411 4BI7 PGA 0.04105 0.27195
412 1H16 PYR 0.01042 0.27176
413 1H2B OCA 0.007358 0.27166
414 1QDS PGA 0.02819 0.2715
415 1RQH PYR 0.01485 0.27132
416 1P9B HDA 0.008004 0.27078
417 1JGS SAL 0.02794 0.27069
418 2EB5 OXL 0.001553 0.27027
419 2JFV FLC 0.003576 0.27013
420 1VR0 3SL 0.04884 0.27004
421 4GO7 THR 0.04948 0.26989
422 4CIB 7UZ 0.01008 0.26961
423 1Q11 TYE 0.01467 0.2691
424 2E1A MSE 0.01751 0.26866
425 1ULE GLA 0.01903 0.26857
426 4WBD ADP 0.01771 0.26855
427 2Q37 3AL 0.02221 0.26847
428 3IHB GLU 0.004785 0.26843
429 2PFC PLM 0.02573 0.26839
430 2J0W ASP 0.001325 0.26814
431 1B74 DGN 0.004744 0.26778
432 1II5 GLU 0.04489 0.26771
433 2BOI MFU 0.004535 0.26756
434 4HCX NDP 0.007618 0.26737
435 1C7R PA5 0.04056 0.26713
436 4KGM ATP 0.04024 0.26682
437 1Y42 TYR 0.02247 0.26681
438 4CCO OGA 0.005604 0.26678
439 1Z6K OAA 0.01098 0.2665
440 2WOR 2AN 0.0102 0.2665
441 1C1L GAL 0.0147 0.26616
442 4FGC PQ0 0.02363 0.26616
443 1H16 COA 0.01426 0.2661
444 3L6R MLI 0.01286 0.26605
445 2PYU IMP 0.031 0.26602
446 1MZV AMP 0.04273 0.26599
447 1RYD GLC 0.01124 0.26587
448 3P7I P7I 0.02841 0.26587
449 1OGD RIP 0.02014 0.26564
450 2AMV BIN 0.03633 0.26484
451 3CBG 4FE 0.02207 0.26455
452 2YLD CMO 0.008871 0.26454
453 3RK0 AMP 0.04638 0.26453
454 3QDY CBS 0.02035 0.26422
455 1NF8 BOG 0.005135 0.26419
456 2WQ5 MIY 0.02856 0.26404
457 2F7C CCU 0.01505 0.2639
458 2DKH 3HB 0.004309 0.26387
459 1QPB PYM 0.04119 0.26379
460 2WCI GSH 0.03606 0.2637
461 4COQ SAN 0.01002 0.26354
462 1GJW GLC 0.01433 0.26343
463 1QO0 BMD 0.008505 0.2631
464 1NX4 AKG 0.03396 0.26295
465 3GTD MLI 0.01007 0.26276
466 2P69 PLP 0.03952 0.26275
467 3QDX A2G 0.01886 0.26247
468 3QDV NDG 0.03115 0.26212
469 1KO0 DLY 0.02294 0.26105
470 2UXR ICT 0.02308 0.26093
471 3DDN HPV 0.0499 0.2609
472 1Y9Q MED 0.02831 0.26078
473 2YIV NBN 0.008757 0.26016
474 1PEA ACM 0.00967 0.26009
475 4PPU TYR 0.0146 0.26006
476 3F81 STT 0.02291 0.26002
477 1KO0 LYS 0.03558 0.2598
478 1IS3 LAT 0.04321 0.25933
479 1QH9 LAC 0.006894 0.25931
480 4WBD CIT 0.01105 0.25905
481 4ASL GAL 0.02897 0.25905
482 1HK8 DGT 0.02824 0.25888
483 3TFC PEP 0.01958 0.2586
484 1RZM PEP 0.03033 0.25782
485 1Z44 NPO 0.002097 0.25752
486 3QDY A2G 0.04257 0.25746
487 3S1W FLC 0.02544 0.25729
488 1T10 F6P 0.004654 0.25714
489 2YIV YIV 0.0155 0.25697
490 2UX9 FMN 0.01295 0.25693
491 1GPJ GMC 0.02331 0.25672
492 3QDW A2G 0.01673 0.25664
493 3MCT 3MC 0.0199 0.25583
494 3CXQ GLP 0.02612 0.25539
495 4EXO PYR 0.02501 0.25529
496 2QLX RM4 0.0296 0.25524
497 2R00 OEG 0.005802 0.25519
498 3QDW NDG 0.04048 0.255
499 2WGC SIA 0.002333 0.25496
500 1O9U ADZ 0.0007445 0.25471
501 1B4B ARG 0.002088 0.25465
502 3CL5 SIO 0.001976 0.25416
503 2VDJ HSE 0.0122 0.25413
504 3ZST ACX 0.012 0.25389
505 4DEC 3PG 0.003428 0.25371
506 1FUR MLT 0.0005014 0.25363
507 2B7N NTM 0.04759 0.2536
508 1PDZ PGA 0.01231 0.25351
509 3UDG TMP 0.0059 0.25317
510 2HW1 FRU 0.01018 0.25302
511 2XI7 XI7 0.0005007 0.25293
512 3VCA PRO 0.02181 0.25292
513 2Q3M MLA 0.004293 0.25224
514 3CBG FER 0.0383 0.2522
515 4M51 BEZ 0.003526 0.25209
516 3R51 MMA 0.03572 0.25199
517 1GPJ CIT 0.01269 0.25193
518 3VPD CIT 0.001185 0.25191
519 2OBT GAL 0.01562 0.25167
520 1TUV VK3 0.0205 0.2516
521 3F8C HT1 0.02326 0.25105
522 1JZN BGC 0.007748 0.25072
523 4LO6 SIA 0.02589 0.24984
524 4G0A G 7.233e-05 0.249
525 1UO4 PIH 0.0003012 0.24872
526 1BTN I3P 0.00594 0.24829
527 3ZGE ASP 0.02897 0.24715
528 1RZM E4P 0.02271 0.24663
529 2VKL MLT 0.03553 0.24618
530 2ASF CIT 0.008479 0.24617
531 3GF2 SAL 0.01858 0.24605
532 3VPD BUA 0.00406 0.24562
533 1H0C AOA 0.01984 0.24528
534 3L24 GOA 0.01997 0.24422
535 2YD6 FLC 0.0004502 0.24411
536 4A6F SEP 0.01664 0.24389
537 1I0Z OXM 0.04149 0.24326
538 1V7R CIT 0.004303 0.24325
539 2X2T GAL 0.005175 0.24265
540 2BZ1 TAU 0.002112 0.24249
541 4B16 NAG 0.005402 0.24237
542 3WCS NAG 0.02671 0.23971
543 1JAC AMG 0.02048 0.23867
544 1HQS CIT 0.0307 0.23867
545 4OTS ATP 0.01305 0.23866
546 3UBW 6SP 2.896e-05 0.23851
547 2D4V FLC 0.01378 0.23501
548 1YOA FMN 0.04013 0.23077
549 3FLK OXL 0.02926 0.21866
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