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Receptor
PDB id Resolution Class Description Source Keywords
1BZL 2.4 Å EC: 1.6.4.8 CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-B ASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS TRYPANOSOMA CRUZI OXIDOREDUCTASE TRYPANOTHIONE REDUCTASE FAD DEPENDENT DISULPHIDE OXIDOREDUCTASE
Ref.: CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS. STRUCTURE FOLD.DES. V. 7 81 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FAD A:601;
B:602;
Valid;
Valid;
none;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
GCG A:603;
A:604;
Valid;
Valid;
none;
none;
submit data
723.862 C27 H49 N9 O10 S2 C(CCN...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1BZL 2.4 Å EC: 1.6.4.8 CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-B ASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS TRYPANOSOMA CRUZI OXIDOREDUCTASE TRYPANOTHIONE REDUCTASE FAD DEPENDENT DISULPHIDE OXIDOREDUCTASE
Ref.: CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS. STRUCTURE FOLD.DES. V. 7 81 1999
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1AOG - MAE C4 H4 O4 C(=C/C(=O)....
2 1BZL - GCG C27 H49 N9 O10 S2 C(CCNC(=O)....
70% Homology Family (15)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4NEV Ki = 12 uM 2JR C21 H25 N3 S c1cc2c(cc[....
2 2WPE ic50 = 0.86 uM WPE C22 H20 Cl N3 O2 CC1=Nc2ccc....
3 2WOW - GCG C27 H49 N9 O10 S2 C(CCNC(=O)....
4 2WOV - NDP C21 H30 N7 O17 P3 c1nc(c2c(n....
5 2WPF ic50 = 0.23 uM WPF C21 H26 Cl N3 Cc1ccc(cc1....
6 2WP6 ic50 = 0.93 uM WP6 C22 H19 Cl N2 CC1=Nc2ccc....
7 2WOI - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
8 2WPC ic50 = 0.42 uM WP7 C26 H27 Cl N4 O2 CC1=Nc2ccc....
9 2WBA - NDP C21 H30 N7 O17 P3 c1nc(c2c(n....
10 1AOG - MAE C4 H4 O4 C(=C/C(=O)....
11 1BZL - GCG C27 H49 N9 O10 S2 C(CCNC(=O)....
12 1FEC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
13 1FEA - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 2TPR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
15 1FEB - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
50% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3SQP ic50 = 7 uM 3J8 C13 H10 N2 O CN1c2ccccc....
2 4GR1 - RGS C20 H32 N6 O12 S2 C(CNC(=O)[....
3 1K4Q - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
4 1DNC - GSH C10 H17 N3 O6 S C(CC(=O)N[....
5 3GRT - TS2 C27 H47 N9 O10 S2 C1CCNC(=O)....
6 2NVK - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
7 1BZL - GCG C27 H49 N9 O10 S2 C(CCNC(=O)....
8 2X8G - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
9 6FMZ - DVQ C8 H18 N2 O2 C1CN(CCN1C....
10 6FMU - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
11 2V6O - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
12 2X99 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
13 6FTC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 2X8H - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
15 6FP4 ic50 = 1.1 mM E1T C9 H6 N2 O2 c1cc2ccc(n....
16 1FEB - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FAD; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 FAD 1 1
2 FAS 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 FAE 0.751773 0.987654
7 SFD 0.651007 0.860215
8 FDA 0.641892 0.906977
9 FNK 0.602564 0.876405
10 62F 0.572327 0.939024
11 F2N 0.566265 0.886364
12 FMN 0.543307 0.876543
13 FA9 0.526316 0.939759
14 6YU 0.516304 0.860215
15 P6G FDA 0.511628 0.908046
16 FAD NBT 0.508876 0.83871
17 A2D 0.504065 0.875
18 P5F 0.491329 0.941176
19 FAD CNX 0.488506 0.8125
20 AR6 0.488372 0.851852
21 APR 0.488372 0.851852
22 AGS 0.484615 0.811765
23 SAP 0.484615 0.811765
24 M33 0.484375 0.864198
25 BA3 0.484127 0.875
26 HEJ 0.48062 0.851852
27 ATP 0.48062 0.851852
28 ADP 0.480315 0.851852
29 B4P 0.480315 0.875
30 AP5 0.480315 0.875
31 ANP 0.477273 0.831325
32 AQP 0.476923 0.851852
33 5FA 0.476923 0.851852
34 48N 0.469388 0.902439
35 OAD 0.467626 0.876543
36 9X8 0.467626 0.833333
37 FAD NBA 0.467033 0.793814
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AT4 0.465116 0.821429
41 AD9 0.462121 0.831325
42 3OD 0.460993 0.876543
43 RBF 0.460938 0.790123
44 FB0 0.460606 0.835165
45 139 0.460526 0.858824
46 AP0 0.46 0.835294
47 A22 0.459854 0.864198
48 ACP 0.458015 0.853659
49 8QN 0.456522 0.864198
50 PRX 0.454545 0.831325
51 A3R 0.453237 0.86747
52 A1R 0.453237 0.86747
53 G3A 0.452055 0.902439
54 T5A 0.45098 0.872093
55 G5P 0.44898 0.902439
56 ATF 0.448529 0.821429
57 50T 0.44697 0.819277
58 6YZ 0.445255 0.853659
59 ACQ 0.444444 0.853659
60 CNV FAD 0.443182 0.917647
61 ADQ 0.442857 0.853659
62 PAJ 0.442857 0.847059
63 5AL 0.441176 0.864198
64 ADX 0.439394 0.775281
65 CA0 0.439394 0.853659
66 A4P 0.437909 0.831461
67 25L 0.4375 0.864198
68 P33 FDA 0.436464 0.817204
69 5SV 0.435714 0.793103
70 OMR 0.434211 0.818182
71 TXE 0.434211 0.890244
72 ABM 0.434109 0.829268
73 A 0.433071 0.82716
74 AMP 0.433071 0.82716
75 4AD 0.432624 0.855422
76 ADJ 0.432258 0.818182
77 B5M 0.431507 0.878049
78 B5Y 0.431507 0.878049
79 BIS 0.430556 0.802326
80 SRA 0.429688 0.788235
81 AFH 0.42953 0.825581
82 NXX 0.427632 0.865854
83 DND 0.427632 0.865854
84 UP5 0.427632 0.878049
85 6V0 0.427632 0.857143
86 TXD 0.427632 0.890244
87 DQV 0.426667 0.8875
88 SRP 0.42446 0.843373
89 PR8 0.423611 0.837209
90 T99 0.423358 0.821429
91 TAT 0.423358 0.821429
92 AMO 0.422535 0.865854
93 TXA 0.42069 0.865854
94 FYA 0.42069 0.864198
95 PTJ 0.42069 0.835294
96 CNA 0.420382 0.865854
97 00A 0.41958 0.823529
98 AHX 0.41958 0.835294
99 MAP 0.41844 0.811765
100 NAI 0.418301 0.845238
101 AU1 0.41791 0.831325
102 A12 0.416667 0.843373
103 AP2 0.416667 0.843373
104 25A 0.415493 0.851852
105 9ZA 0.415493 0.845238
106 9ZD 0.415493 0.845238
107 COD 0.415094 0.842697
108 4TC 0.412903 0.879518
109 APC 0.411765 0.843373
110 ME8 0.410959 0.806818
111 1ZZ 0.410959 0.806818
112 NB8 0.410959 0.835294
113 4UW 0.409091 0.825581
114 NAX 0.409091 0.837209
115 F2R 0.408805 0.850575
116 RBY 0.408759 0.843373
117 ADV 0.408759 0.843373
118 P1H 0.405882 0.818182
119 OOB 0.405594 0.864198
120 LAD 0.40411 0.825581
121 A A 0.40411 0.829268
122 UPA 0.403846 0.86747
123 4UU 0.401316 0.833333
124 GA7 0.401316 0.865854
125 A3D 0.401235 0.876543
126 80F 0.401235 0.808989
127 XAH 0.4 0.806818
128 DLL 0.4 0.864198
Ligand no: 2; Ligand: GCG; Similar ligands found: 14
No: Ligand ECFP6 Tc MDL keys Tc
1 GCG 1 1
2 TS5 0.863636 0.976744
3 TS4 0.657895 0.934783
4 GSH 0.6 0.860465
5 HGS 0.558824 0.886364
6 HCG 0.507042 0.883721
7 3GC 0.484375 0.790698
8 GTS 0.44 0.622951
9 GSM 0.434211 0.804348
10 GDS 0.421053 0.847826
11 GS8 0.421053 0.74
12 GSF 0.415584 0.678571
13 AHE 0.410256 0.822222
14 HGD 0.405063 0.808511
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1BZL; Ligand: FAD; Similar sites found with APoc: 1082
This union binding pocket(no: 1) in the query (biounit: 1bzl.bio1) has 47 residues
No: Leader PDB Ligand Sequence Similarity
1 1P0Z FLC None
2 1GQ2 NAP 1.02881
3 3SSO SAH 1.19332
4 1ZBQ NAD 1.22324
5 1LJ8 NAD 1.23457
6 1M2W NAD 1.23457
7 4U63 MHF 1.23457
8 1VJT NAD 1.24224
9 2D2I NAP 1.31579
10 6C4T NA7 1.33333
11 6C4N NAP 1.3363
12 4HXY NDP 1.36986
13 1MUU NAD 1.37615
14 1MV8 NAD 1.37615
15 4KIB SAH 1.40056
16 3LST SAH 1.43678
17 1GZ4 ATP 1.44033
18 3L9W AMP 1.45278
19 3L9W GSH 1.45278
20 2YYY NAP 1.45773
21 1KK1 GNP 1.46341
22 6A3J NAI 1.46341
23 5A1T NAI 1.46628
24 5A1T OXM 1.46628
25 3B20 NAD 1.47493
26 3B1J NAD 1.47493
27 5Y77 FAD 1.47992
28 1U8X NAD 1.48305
29 1RPN NDP 1.49254
30 4UOX PUT 1.49893
31 6A0S HSE 1.50602
32 6A0S NDP 1.50602
33 3VSE SAH 1.50754
34 3S5W NAP 1.51188
35 3S5W FAD 1.51188
36 2AG8 NAP 1.52091
37 5H81 NAP 1.54242
38 1OMO NAD 1.5528
39 2IXB NAD 1.57658
40 2IXB A2G 1.57658
41 4ZRN NAD 1.60256
42 2EG5 SAH 1.6129
43 1SQF SAM 1.6317
44 1GR0 NAD 1.63488
45 4N49 SAM 1.63551
46 4MIG G3F 1.64609
47 1VKO NAD 1.64609
48 6B74 BEN 1.64609
49 5TS5 FAD 1.65289
50 5Z21 NAI 1.67598
51 4UCI SAM 1.68675
52 1YS4 NAP 1.69492
53 3EWP APR 1.69492
54 3U4C NDP 1.77936
55 1RM4 NDP 1.78042
56 2IID PHE 1.85185
57 2IID FAD 1.85185
58 2QA1 FAD 1.85185
59 4HA6 FAD 1.85185
60 5WP5 SAH 1.85185
61 5L53 NAP 1.85185
62 5WP4 SAH 1.85185
63 5OBU ANP 1.85185
64 1T26 NAI 1.86335
65 1T26 GBD 1.86335
66 4D7E FAD 1.8648
67 4RQU NAD 1.86667
68 1FP1 SAH 1.88172
69 1I36 NAP 1.89394
70 6AIN FAD 1.91388
71 1G60 SAM 1.92308
72 2RGH FAD 1.92644
73 2OEM 1AE 1.93705
74 2X6T NAP 1.96078
75 4OOE NDP 1.9802
76 1N2X SAM 1.99336
77 5BUK FAD 2
78 1X7D NAD 2
79 1E5Q NDP 2
80 5AHM IMP 2
81 1X7D ORN 2
82 4RSL FAD 2.02247
83 1M1B SPV 2.0339
84 6F7L FAD 2.0362
85 5BRT FAD 2.05761
86 5BRT CH9 2.05761
87 5OC1 FAD 2.05761
88 3GDN HBX 2.05761
89 3GDN FAD 2.05761
90 1COY AND 2.05761
91 1COY FAD 2.05761
92 4TVD BGC 2.05761
93 3PT9 SAH 2.05761
94 4M00 SUC 2.05761
95 1YBH P22 2.05761
96 1WP4 NDP 2.07612
97 2CVZ NDP 2.07612
98 2YX1 SFG 2.08333
99 1N5D NDP 2.08333
100 4MDH NAD 2.09581
101 5G4L NDP 2.0979
102 5OJ7 AR6 2.0979
103 1DSS NAD 2.1021
104 5MDH NAD 2.1021
105 1V6A TRE 2.10843
106 6C4M NAP 2.1097
107 3A06 NDP 2.12766
108 2WK1 SAH 2.12766
109 3A06 FOM 2.12766
110 6APL C5P 2.13904
111 5XNC MTA 2.15633
112 3GMB FAD 2.16867
113 2PK3 A2R 2.18069
114 2VSU ACO 2.18182
115 2C7G FAD 2.19298
116 2C7G ODP 2.19298
117 5NA1 FAD 2.20588
118 1DL5 SAH 2.2082
119 4JZ8 CIT 2.2082
120 2PX8 SAH 2.23048
121 2VAR AMP 2.23642
122 3DUW SAH 2.24215
123 1NVM NAD 2.24359
124 3VC1 SAH 2.24359
125 5TTJ FAD 2.2449
126 3G5S FAD 2.25734
127 1EQ2 NAP 2.25806
128 2VVL FAD 2.26337
129 3UCL NAP 2.26337
130 3UCL CYH 2.26337
131 3UCL FAD 2.26337
132 2VVM FAD 2.26337
133 4C4A SAH 2.26337
134 5E4R NAP 2.26337
135 3UOY NAP 2.26337
136 3UOY FAD 2.26337
137 5LTJ BEF 2.26337
138 2ZPA ADP 2.26337
139 2D7I UDP 2.26337
140 3A1I UNU 2.26337
141 1H5Q NAP 2.26415
142 4A6D SAM 2.26629
143 2D3N GLC GLC GLC 2.26804
144 4DSG FAD 2.27273
145 4DSG UDP 2.27273
146 3WBF NAP 2.29508
147 3WBF API 2.29508
148 3ZYR NAG NAG BMA MAN MAN NAG NAG 2.29885
149 3ZYR ASN NAG NAG BMA MAN MAN NAG NAG 2.29885
150 1KJ8 GAR 2.30179
151 5L4L NAP 2.30263
152 2CH5 NAG 2.30548
153 1YJQ NAP 2.31023
154 1Y8Q ATP 2.31214
155 2PWY SAH 2.32558
156 4JJF FE9 2.32558
157 4JJF N2I 2.32558
158 5T96 79J 2.33918
159 5ERG SAM 2.34987
160 1RYI GOA 2.35602
161 1RYI FAD 2.35602
162 2ZIF SAM 2.3569
163 2NXE SAM 2.3622
164 1XTP SAI 2.3622
165 3GRU AMP 2.37288
166 5HXI FAD 2.37467
167 5HXI 5HN 2.37467
168 2Q1S NAI 2.38727
169 4PLG NAI 2.39521
170 4PLG OXM 2.39521
171 2AOT SAH 2.39726
172 3O03 NAP 2.4055
173 2GLX NDP 2.40964
174 2EWM NAD 2.40964
175 3Q72 GNP 2.40964
176 4BLW SAH 2.42215
177 5EES NAP 2.42915
178 1B8U NAD 2.43161
179 5BVA FAD 2.44499
180 3TKY SAH 2.44565
181 1WG8 SAM 2.45614
182 1HDR NAD 2.45902
183 1NJR XYL 2.46479
184 4K5S FAD 2.46914
185 3E1T FAD 2.46914
186 2Z3Y F2N 2.46914
187 4REP FAD 2.46914
188 4MOP 2H5 2.46914
189 2JHP SAH 2.46914
190 4AP3 FAD 2.46914
191 4AP3 NAP 2.46914
192 6ER9 FAD 2.46914
193 1O6Z NAD 2.46914
194 6ER9 NAP 2.46914
195 4K5S PM0 2.46914
196 1JG9 GLC 2.46914
197 5YF1 SFG 2.46914
198 5DNC ASN 2.46914
199 2WME NAP 2.46914
200 1Q19 SSC 2.46914
201 2WW4 ADP 2.4735
202 5I34 GDP 2.49433
203 1H2B NAJ 2.50696
204 2ZXI FAD 2.51177
205 1KOL NAD 2.51256
206 1EZ4 NAD 2.51572
207 1GY8 NAD 2.51889
208 1LDN NAD 2.53165
209 1H82 FAD 2.54237
210 1H82 GZZ 2.54237
211 5EZ7 FAD 2.55102
212 3NC9 TR3 2.55591
213 4KQW NAP 2.57143
214 3TWO NDP 2.58621
215 2B4R AES 2.6087
216 2B4R NAD 2.6087
217 3ESS 18N 2.6087
218 1DIG NAP 2.61438
219 1VQW FAD 2.62582
220 5NM7 GLY 2.63158
221 4YUW 4JU 2.63158
222 4YUW S4M 2.63158
223 6C8R SAH 2.63852
224 5A3B APR 2.64026
225 3V1Y NAD 2.67062
226 1PS9 FAD 2.6749
227 5YB7 FAD 2.6749
228 5YB7 ORN 2.6749
229 5EB4 FAD 2.6749
230 2AQJ FAD 2.6749
231 2AQJ TRP 2.6749
232 3X0V FAD 2.6749
233 1NAA ABL 2.6749
234 1NAA 6FA 2.6749
235 1PS9 NAP 2.6749
236 1R37 NAD 2.6749
237 1QMG APX 2.6749
238 6FOG OXL 2.67857
239 5OJL TXP 2.68456
240 2GV8 FAD 2.68456
241 2GVC FAD 2.68456
242 2GV8 NDP 2.68456
243 4Z0H NAD 2.69461
244 2DBZ NAP 2.69461
245 6BII NAP 2.7027
246 1HDG NAD 2.71084
247 5NUF NAD 2.71084
248 5NUE NAD 2.71084
249 5U5G NAP 2.71186
250 5THY SAH 2.71605
251 5THZ SAH 2.71605
252 4LWP SAH 2.71739
253 4E5N NAD 2.72727
254 2GSD NAD 2.73632
255 3CB2 GDP 2.73684
256 1KYZ SAH 2.73973
257 2HJR APR 2.7439
258 2Q2V NAD 2.7451
259 3BXF 13P 2.7451
260 5Z75 NAD 2.75229
261 2JK0 ASP 2.76923
262 5KOK SAH 2.77078
263 1RTF BEN 2.77778
264 1LUA NAP 2.78746
265 1NVT NAP 2.78746
266 3ORF NAD 2.78884
267 4DMG SAM 2.79898
268 4NBU NAI 2.8
269 2B5W NAP 2.80112
270 1PL6 NAD 2.80899
271 1PL6 572 2.80899
272 3GEG NAD 2.83401
273 5G3U FDA 2.83688
274 5G3U ITW 2.83688
275 5O98 NAP 2.83912
276 5GSN FAD 2.86976
277 5GSN NAP 2.86976
278 2YG3 FAD 2.86976
279 5GSN MMZ 2.86976
280 1PN0 FAD 2.88066
281 1PN0 IPH 2.88066
282 4AT0 FAD 2.88066
283 4KVL PLM 2.88066
284 4CP8 MLI 2.88066
285 5ZBC FAD 2.88248
286 4J36 FAD 2.89157
287 4J36 1HR 2.89157
288 5A1S FLC 2.90179
289 4D3F NAP 2.90323
290 2BES RES 2.90698
291 4O0L NDP 2.90909
292 1V1A ADP 2.91262
293 1KYQ NAD 2.91971
294 4YT4 FE9 2.93333
295 5XVH NAP 2.94118
296 4Y9D NAI 2.95082
297 2O07 MTA 2.96053
298 2O07 SPD 2.96053
299 3I51 45C 2.96296
300 2QV7 ADP 2.96736
301 1DLJ NAI 2.98507
302 1DLJ UGA 2.98507
303 6CEP NAD 2.99401
304 6CEP OXM 2.99401
305 1RJD SAM 2.99401
306 3RFV NAI 2.99625
307 3RFV 15L 2.99625
308 3G2O SAM 3.01003
309 6BQ6 TER 3.02115
310 1C0I BE2 3.0303
311 1C0I FAD 3.0303
312 5GM1 SAH 3.0303
313 3I9U DTU 3.04183
314 5GT9 NAP 3.04183
315 6F3M NAD 3.04348
316 5GZ6 NDP 3.06748
317 5GZ6 7C3 3.06748
318 5F5N NAD 3.11419
319 2PT9 S4M 3.11526
320 3C1O NAP 3.11526
321 2PT9 2MH 3.11526
322 3H5N ATP 3.11615
323 4R8L ASP 3.11688
324 1F06 NDP 3.125
325 1KEV NDP 3.1339
326 1A5Z NAD 3.1348
327 4CJX NAP 3.1348
328 5YAP 8S0 3.15789
329 5YAP NAI 3.15789
330 1EJ4 M7G 3.15789
331 3GU3 SAH 3.16901
332 3GGO ENO 3.18471
333 3GGO NAI 3.18471
334 6C0B PAM 3.20513
335 5W7K SAH 3.20513
336 4XDZ NDP 3.207
337 5A96 GTP 3.21285
338 1D1T NAD 3.21716
339 2RGJ FAD 3.23383
340 1HYH NAD 3.23625
341 2Y6Q FAD 3.26633
342 2Y6Q I7T 3.26633
343 1QAN SAH 3.27869
344 4CQM NAP 3.27869
345 3ABI NAD 3.28767
346 3Q9T FAY 3.29218
347 4B63 ORN 3.29218
348 4B63 NAP 3.29218
349 4B63 FAD 3.29218
350 5WKC F50 3.29218
351 4J1Q NDP 3.29218
352 1T9D P22 3.29218
353 5DN9 NAD 3.2967
354 3LU1 NAD 3.2967
355 9LDT NAD 3.31325
356 9LDB NAD 3.31325
357 3I53 SAH 3.31325
358 4ZVV GN0 3.31325
359 4ZVV NAD 3.31325
360 2VYN NAD 3.32326
361 1GAD NAD 3.33333
362 3I6B KDO 3.33333
363 1K3T BRZ 3.34262
364 1LDM NAD 3.34347
365 4EUE NAI 3.34928
366 2CVQ NDP 3.36391
367 3EGI ADP 3.39806
368 3NYC FAD 3.41207
369 3NYC IAR 3.41207
370 5OCM NAP 3.43643
371 5HS2 CTP 3.44828
372 4W6Z 8ID 3.45821
373 3ULK NDP 3.46232
374 2NU8 COA 3.47222
375 1QZZ SAM 3.47594
376 4IWN GEK 3.49345
377 1YY5 FAD 3.49794
378 1RSG FAD 3.49794
379 4IV9 FAD 3.49794
380 2WET FAD 3.49794
381 1X87 NAD 3.49794
382 2DKH FAD 3.49794
383 2DKH 3HB 3.49794
384 3K5I AIR 3.49794
385 4XYB NDP 3.49794
386 1GEG NAD 3.51562
387 1P1C SAH 3.51759
388 5U19 SAH 3.51906
389 5U19 827 3.51906
390 3OZ2 FAD 3.52645
391 1ZH8 NAP 3.52941
392 4MO2 FAD 3.53261
393 4MO2 FDA 3.53261
394 2I7C AAT 3.53357
395 1GUZ NAD 3.54839
396 2G5C NAD 3.55872
397 3VYW SAM 3.57143
398 2V6G NAP 3.57143
399 2F1K NAP 3.58423
400 3GF4 UPG 3.58974
401 3GF4 FAD 3.58974
402 5ZYN FAD 3.60934
403 4B4U NAP 3.63036
404 2GCG NDP 3.63636
405 3B4Y F42 3.65169
406 1O8B ABF 3.65297
407 1C3V NDP 3.67347
408 3DMH SAM 3.67454
409 3DMH GMP 3.67454
410 3V1U NAD 3.67965
411 1IM8 SAI 3.68852
412 4Z24 FAD 3.7037
413 1D4D FAD 3.7037
414 5DNK SAH 3.7037
415 6F97 FAD 3.7037
416 3K7M FAD 3.7123
417 3C7A NAD 3.71287
418 1FWV SGA MAG FUC 3.73134
419 3T7S SAM 3.73134
420 1CDO NAD 3.74332
421 1ORR NAD 3.7464
422 3H9E NAD 3.75723
423 1V8B NAD 3.75783
424 2XNJ FAD 3.7594
425 2R2N KYN 3.76471
426 1VL0 NAI 3.76712
427 5Z20 NAI 3.76812
428 2FYF PLP 3.76884
429 5FEU NAP 3.78007
430 5KOX RFP 3.78151
431 5KOX FAD 3.78151
432 4RQL SNE 3.78151
433 3U31 NAD 3.7931
434 3C3Y SAH 3.79747
435 1HTW ADP 3.79747
436 1NE7 AGP 3.80623
437 5MGZ SAH 3.81356
438 1TPY SAH 3.83275
439 1KPH SAH 3.83275
440 1KPG SAH 3.83275
441 5X68 FAD 3.83632
442 2YY7 NAD 3.84615
443 3KO8 NAD 3.84615
444 1ELI PYC 3.85604
445 4GLL NAD 3.85757
446 1DMH MCT 3.85852
447 4XB2 NDP 3.8806
448 4XB2 HSE 3.8806
449 4NBW NAD 3.89105
450 4FZV SAM 3.89972
451 1REO FAD 3.90947
452 1KNR FAD 3.90947
453 4D04 NAP 3.90947
454 4D04 FAD 3.90947
455 5HSA FAS 3.90947
456 1PZG A3D 3.92749
457 2BOY BHO 3.93701
458 5KVA SAM 3.95683
459 2I3G NAP 3.97727
460 6EWR PMP 3.98126
461 5ZW3 SAH 4
462 4BJZ P3A 4.00943
463 4BJZ FAD 4.00943
464 5O4J PJL 4.0146
465 5O4J SAH 4.0146
466 5O4J 9KH 4.0146
467 3G89 SAM 4.01606
468 3AXB PRO 4.01786
469 3AXB FAD 4.01786
470 3FPF MTA 4.02685
471 3FPF TNA 4.02685
472 1F8F NAD 4.04313
473 5CAE COA 4.05063
474 5CAE SIN 4.05063
475 3FUU ADN 4.05904
476 2VDV SAM 4.06504
477 4CCK OGA 4.06852
478 4CCO OGA 4.06852
479 6DNT NAD 4.06977
480 5AHW CMP 4.08163
481 6HKE LMR 4.08805
482 6HKE MLT 4.08805
483 3QJ4 FAD 4.09357
484 2CDC NAP 4.09836
485 2CDC XYP 4.09836
486 2CDC XYS 4.09836
487 1YQD NAP 4.09836
488 5D4V SAH 4.10448
489 5TC4 NAD 4.11392
490 1WDK NAD 4.11523
491 2GDZ NAD 4.11985
492 1UAY ADN 4.13223
493 5E1M SAH 4.14938
494 1CF2 NAP 4.1543
495 4L8V NAP 4.1543
496 5AHO TLA 4.16667
497 4GKV NAD 4.16667
498 1OBB NAD 4.16667
499 2EV9 SKM 4.18251
500 2EV9 NAP 4.18251
501 2IVD FAD 4.1841
502 1EBF NAD 4.18994
503 6EL3 NAP 4.19948
504 1ZGA SAH 4.20168
505 4OM8 NAD 4.20712
506 5K0A FAD 4.24242
507 1JAY NAP 4.24528
508 1XDS SAM 4.27807
509 3TLJ SAH 4.28954
510 5LOG SAH 4.29185
511 4KRG SAH 4.29185
512 1WPQ NAD 4.29799
513 6DVH FMN 4.31472
514 2BRY FAD 4.32099
515 4TXI FAD 4.32099
516 3TKA SAM 4.32277
517 1VI2 NAD 4.33333
518 5E72 SAM 4.33526
519 5W75 GDP 4.33673
520 4M37 SAH 4.37318
521 1G55 SAH 4.37318
522 1Q9I TEO 4.37828
523 1Q9I FAD 4.37828
524 1R18 SAH 4.40529
525 3A27 SAM 4.41176
526 4OPC PGT 4.41501
527 4OPC FDA 4.41501
528 6B92 SAH 4.42177
529 2EFJ SAH 4.42708
530 4DPL NAP 4.45682
531 4ZCC FAD 4.46429
532 4ZCC NAI 4.46429
533 3WMX NAD 4.46927
534 2JJQ SAH 4.47059
535 2B9W FAD 4.48113
536 3AB4 THR 4.49438
537 3AB4 LYS 4.49438
538 2DTJ THR 4.49438
539 3K56 IS3 4.51128
540 1NPD NAD 4.51389
541 4R5M NAP 4.52128
542 1QO8 FAD 4.52675
543 4YNU LGC 4.52675
544 4YNU FAD 4.52675
545 5J7X FAD 4.52675
546 4EIP FAD 4.52675
547 4EIP K2C 4.52675
548 2FR1 NDP 4.52675
549 3ZIU LSS 4.52675
550 2JL1 NAP 4.52962
551 5AYV NAP 4.53074
552 5AYV KPL 4.53074
553 2DPM SAM 4.57746
554 3FPZ AHZ 4.60123
555 1OUW MLT 4.60526
556 5UFN SAH 4.62185
557 5TCI MLI 4.63415
558 1W6U NAP 4.63576
559 3TN7 NJP 4.66926
560 5K4W NAI 4.6729
561 3Q3C NAD 4.68227
562 1O0S NAI 4.73251
563 5JJR SAH 4.73251
564 1E1M FAD 4.78261
565 1E1M NAP 4.78261
566 4XZ3 COA 4.78261
567 4X9M FAD 4.78469
568 1LK7 DER 4.80349
569 1J0X NAD 4.81928
570 5HJM MTA 4.82955
571 1JJV ATP 4.85437
572 1OC2 NAD 4.88506
573 1OC2 TDX 4.88506
574 3ZNN FAD 4.89914
575 3ZNN 4WL 4.89914
576 3WGT QSC 4.89914
577 3WGT FAD 4.89914
578 5ZBL AMP 4.92611
579 2GMH FAD 4.93827
580 4PIV NDP 4.93827
581 1F3L SAH 4.98442
582 1SAY PYR 4.98615
583 5A04 NDP 5.01475
584 5A04 BGC 5.01475
585 1XG5 NAP 5.01792
586 1UP7 NAD 5.03597
587 3HDY FAD 5.03778
588 3HDY FDA 5.03778
589 3HDY GDU 5.03778
590 3L4S NAD 5.05952
591 3L4S 3PG 5.05952
592 1JQ3 AAT 5.06757
593 4NTC FAD 5.07463
594 1QB7 ADE 5.08475
595 1U4J MAN 5.08475
596 3KB6 NAD 5.08982
597 6H3O FAD 5.14403
598 3GXO SAH 5.14905
599 3GWZ SAH 5.14905
600 3VPH NAD 5.16129
601 3VPH OXM 5.16129
602 3B1F NAD 5.17241
603 2BZG SAH 5.17241
604 5YU3 PRO 5.23256
605 5YU3 NAD 5.23256
606 4URF NAD 5.24194
607 3C6K MTA 5.24934
608 3C6K SPD 5.24934
609 2O4C NAD 5.26316
610 4RPL FAD 5.26316
611 4RPL 3UC 5.26316
612 4P5E N6P 5.26316
613 3LKZ SFG 5.29595
614 5JE8 NAD 5.29801
615 1W8D NAP 5.29801
616 1W73 NAP 5.29801
617 4E13 NAD 5.30035
618 2VHW NAI 5.30504
619 1GZ6 NAI 5.32915
620 1BW9 NAD 5.33708
621 1BXG NAD 5.33708
622 1I9G SAM 5.35714
623 1Z82 NDP 5.37313
624 5ZI9 FLC 5.38462
625 1X1T NAD 5.38462
626 6FDF SAH 5.38922
627 1YKF NAP 5.39773
628 4KOA NDP 5.40541
629 4JK3 NAD 5.40541
630 6CI9 NAP 5.40541
631 5X62 SAH 5.41872
632 2WA2 SAM 5.43478
633 4RLT FSE 5.44218
634 3H8V ATP 5.47945
635 3I7S PYR 5.47945
636 4XUC SAM 5.50459
637 4XUC 43G 5.50459
638 3NJ4 NAD 5.51724
639 3NJ4 AFX 5.51724
640 2JB2 PHE 5.52147
641 2JB2 FAD 5.52147
642 3LCC SAH 5.53191
643 3AD8 NAD 5.55556
644 5WGR FAD 5.55556
645 3AD8 FAD 5.55556
646 3AD8 PYC 5.55556
647 2EJU SAH 5.55556
648 1LLU NAD 5.55556
649 1AV5 AP2 5.55556
650 1L1E SAH 5.57491
651 4XGX ADP 5.58824
652 5ULP KB1 5.59701
653 4N82 FMN 5.61798
654 5YRF GLC GLC 5.6338
655 5I39 FAD 5.63725
656 3OA2 NAD 5.66038
657 5Z2F NAP 5.66038
658 1PJS NAD 5.68928
659 2IZ1 ATR 5.6962
660 4TSK NDP 5.71429
661 5KVS NAP 5.71429
662 5UAO FAD 5.73013
663 2BD0 NAP 5.7377
664 1CER NAD 5.74018
665 1R4W GSH 5.75221
666 1GPE FAD 5.76132
667 2RGO FAD 5.76132
668 4QTU SAM 5.76923
669 6FA4 D1W 5.78035
670 6GNC FAD 5.78231
671 3OJO NAD 5.80046
672 3VNM SDD 5.80205
673 2BNE U5P 5.80913
674 5EIN NAP 5.81395
675 5MTE BB2 5.83942
676 2QMC GTB 5.85106
677 3NKS FAD 5.87002
678 4CNK FAD 5.88235
679 4TQG NDP 5.88235
680 4RDH AMP 5.90278
681 4RDI ATP 5.90278
682 4XDY NAI 5.91716
683 5EOW FAD 5.92593
684 1J5P NAD 5.92885
685 2Q46 NAP 5.92885
686 1GTE FAD 5.96708
687 3AQ4 GDP 5.97826
688 1NV8 MEQ 5.98592
689 1NV8 SAM 5.98592
690 2R4J FAD 5.98802
691 2R4J 13P 5.98802
692 1VL8 NAP 5.99251
693 1IY8 NAD 5.99251
694 1JNR FAD 6
695 4KRI SAH 6.00462
696 3BAZ NAP 6.00601
697 4XFR CIT 6.08899
698 1RKX NAD 6.16247
699 5JFL NAD 6.17284
700 4ZGS NAD 6.21762
701 1FK8 NAD 6.22568
702 2A92 NAI 6.23053
703 1L7E NAI 6.25
704 1L3I SAH 6.25
705 2HNK SAH 6.27615
706 4Z9D NAD 6.28571
707 2FK8 SAM 6.28931
708 5DWQ SFG 6.30372
709 5DX1 SFG 6.30372
710 5DX8 SFG 6.30372
711 5DXA SFG 6.30372
712 5DX0 SFG 6.30372
713 5UR0 NAD 6.30372
714 1ZQ9 SAM 6.31579
715 4ITU NAI 6.3197
716 4TM3 FAD 6.32054
717 1U1I NAD 6.37755
718 2CFC NAD 6.4
719 5LD5 NAD 6.42458
720 3DAG FEG 6.42458
721 4NEC SAH 6.43939
722 5N2I NAP 6.46552
723 5W3K 9TY 6.47059
724 5W3K NDP 6.47059
725 2BGM NAJ 6.47482
726 2JAP NDP 6.47773
727 2JAH NDP 6.47773
728 6FHO FAD 6.51629
729 1P31 EPU 6.52632
730 1P3D UMA 6.52632
731 1Q7B NAP 6.55738
732 2AHR NAP 6.56371
733 4BVA NDP 6.56716
734 2E5V FAD 6.5678
735 1NW5 SAM 6.58307
736 3AYI FAD 6.58436
737 3AYI HCI 6.58436
738 6GNA FAD 6.59722
739 4AR8 IP8 GLY PRO ALA 6.59898
740 2Q1W NAD 6.60661
741 3GDH SAH 6.639
742 1GVF PGH 6.64336
743 4PLT NAI 6.64653
744 4PLT OXM 6.64653
745 3AY6 NAI 6.69145
746 2PV7 NAD 6.71141
747 5FI3 NAP 6.72269
748 4IF4 BEF 6.73077
749 1X14 NAD 6.73317
750 4YAC NAI 6.73401
751 3WLE NAD 6.74487
752 1C3X 8IG 6.76692
753 1GV0 NAD 6.77419
754 4BV6 FAD 6.79012
755 4A59 AMP 6.79012
756 3MAG SAH 6.84039
757 1GEE NAD 6.89655
758 3A4T SFG 6.93431
759 3OFK SAH 6.94444
760 5ZI2 ADP 6.95652
761 5ZI2 NAD 6.95652
762 1DRV A3D 6.95971
763 2ZWI C5P 6.97051
764 2VT3 ATP 6.97674
765 5MBX FAD 6.99588
766 5MBX SP5 6.99588
767 1OW3 GDP 7.02479
768 5HPY GDP 7.02703
769 1UJ5 5RP 7.04846
770 4MZU COA 7.05128
771 3MCT SAH 7.07071
772 1I8T FAD 7.08447
773 2XVF FAD 7.11207
774 2XVE FAD 7.11207
775 5Y8L NAD 7.11864
776 5Y8L HUI 7.11864
777 5UAV NDP 7.14286
778 5UAV TFB 7.14286
779 2V6A CAP 7.14286
780 1IR2 CAP 7.14286
781 5MZI FAD 7.15835
782 5MZI FYK 7.15835
783 2XWL CTP 7.17489
784 1LTH NAD 7.21003
785 1M2K APR 7.22892
786 3FIU AMP 7.22892
787 5NMX FAD 7.29412
788 5NMX NAP 7.29412
789 3A25 SAM 7.30897
790 5OVL NAP 7.33333
791 5Z2L NDP 7.34694
792 1YKJ FAD 7.36041
793 1YKJ PHB 7.36041
794 1RP0 AHZ 7.39437
795 1O94 ADP 7.40741
796 1DJN ADP 7.40741
797 1KGZ PRP 7.53623
798 5Z3I ADE 7.54717
799 4D79 ATP 7.6087
800 5C9P FUC 7.61155
801 3QVP FAD 7.61317
802 2Q28 ADP 7.61317
803 2NAD NAD 7.63359
804 1N1G BCP 7.65027
805 5E9W SAH 7.69231
806 1MID LAP 7.69231
807 5E8J SAH 7.69231
808 2C29 NAP 7.71513
809 1WY7 SAH 7.72947
810 3DXY SAM 7.79817
811 1WVG APR 7.79944
812 5YSS NAD 7.8125
813 4FWE FAD 7.81893
814 3MB5 SAM 7.84314
815 4NBT NAD 7.91667
816 1SC6 NAD 7.92079
817 2W58 ADP 7.92079
818 5EVY FAD 7.99087
819 5ODQ FAD 8.02469
820 4U8P FDA 8.02469
821 4U8P UDP 8.02469
822 3X0D SAH 8.02469
823 1E3W NAD 8.04598
824 2DT5 NAD 8.05687
825 1E6W NAD 8.07692
826 3O7W SAM 8.16327
827 5CIC 51R 8.16327
828 2HYQ MAN MAN 8.19672
829 1FP2 SAH 8.23864
830 3JWH SAH 8.29493
831 5TUK FAD 8.33333
832 5BWD FUM 8.33333
833 5X20 NAD 8.33333
834 1VM6 NAD 8.33333
835 5A7Y SAH 8.33333
836 2BTO GTP 8.33333
837 3H2B SAH 8.37438
838 4XQC NAD 8.42105
839 4XQC 13D 8.42105
840 2P41 SAH 8.52459
841 3QV1 NAD 8.53659
842 5FJN FAD 8.55263
843 5FJN BE2 8.55263
844 5X9D 80F 8.55263
845 1F8G NAD 8.59375
846 5OVK NDP 8.59375
847 2OQ5 BEN 8.62069
848 3CIF NAD 8.6351
849 3CIF G3H 8.6351
850 1APZ ASP 8.64198
851 4K37 SAM 8.64865
852 5KZV HCD 8.66142
853 4YRY NAD 8.76068
854 4YRY FAD 8.76068
855 1NYT NAP 8.85609
856 1Q0S SAH 8.88031
857 3KO0 TFP 8.91089
858 3T31 DCQ 8.92449
859 3T31 FAD 8.92449
860 1JG3 ADN 8.93617
861 1XCL SAH 8.93617
862 3WXB NDP 8.96057
863 5BW4 SAM 8.98876
864 2CUL FAD 9.05172
865 3EVG SAH 9.09091
866 3GFB NAD 9.14286
867 4YCA NDP 9.18367
868 3BGD SAH 9.23077
869 3BGD PM6 9.23077
870 4LFL TG6 9.25926
871 3OJF NDP 9.33852
872 1E6E FAD 9.375
873 4USR FAD 9.41828
874 2DFV NAD 9.51009
875 4ONQ SFG 9.52381
876 2II3 CAO 9.54198
877 5ZZ6 ADP 9.61539
878 5ZZ6 NAD 9.61539
879 5KKA 6V0 9.61539
880 5N6C NAD 9.66667
881 4GUT FAD 9.67742
882 4GUS FAD 9.67742
883 4HSU FAD 9.67742
884 6BWL NAD 9.7561
885 1D4O NAP 9.78261
886 1P0F NAP 9.91957
887 1XXR MAN 9.93789
888 1P9B HDA 9.95475
889 1HKU NAD 10.0559
890 4LNU GDP 10.0592
891 5EIB GTP 10.0592
892 2GAG NAD 10.101
893 2GAG FAD 10.101
894 2GAG FOA 10.101
895 5BSH PRO 10.1083
896 4Y1B NAP 10.1176
897 1Z45 NAD 10.2881
898 1ZEM NAD 10.3053
899 1SOW NAD 10.3659
900 1HE1 AF3 10.3704
901 1VE3 SAM 10.5727
902 4YSX FAD 10.6383
903 1BXK NAD 10.7042
904 5TUF TDC 10.7579
905 5TUF FAD 10.7579
906 3F4F UMP 10.7784
907 5CUQ NSC 10.8614
908 3IHG FAD 10.9053
909 2HK9 ATR 10.9091
910 2HK9 NAP 10.9091
911 5YEC ATP 10.9244
912 3CTY FAD 10.9718
913 1C1X NAD 10.9859
914 1C1X HFA 10.9859
915 1PNO NAP 11.1111
916 1DJL NAP 11.1111
917 3HVJ 705 11.3122
918 4C3Y FAD 11.3169
919 4C3Y ANB 11.3169
920 4PU6 ASP 11.4504
921 2OOR NAD 11.4943
922 2OOR TXP 11.4943
923 1U25 IHS 11.5727
924 3A28 NAD 11.6279
925 1O5I NAD 11.6466
926 2QQF A1R 11.6883
927 2OD9 A1R NCA 11.6883
928 5MVR ADP 11.7284
929 4NTD FAD 11.7647
930 1UXG NAD 11.9741
931 1UXG FUM 11.9741
932 4YMH SAH 12.0833
933 5OFW 9TW 12.1076
934 5LWY OLB 12.1495
935 1J49 NAD 12.3123
936 1I1N SAH 12.3894
937 3AFN NAP 12.4031
938 4POO SAM 12.5
939 5AOV NAP 12.5514
940 4OBW SAM 12.8405
941 3WV8 ATP 12.844
942 3CBG SAH 12.931
943 2QIE 8CS 12.987
944 4USQ FAD 13.0194
945 1E3I CXF 13.0319
946 5FA8 SAM 13.0435
947 3GD4 NAD 13.1687
948 3GD4 FAD 13.1687
949 2HMT NAI 13.1944
950 6C5B SAH 13.1965
951 1P77 ATR 13.2353
952 5F8F SFG 13.2626
953 4IMG NGF 13.3106
954 5YRI GLC GLC 13.3803
955 5N5D SAM 13.7168
956 1NM5 NAD 13.7931
957 5N53 8NB 13.8462
958 6FX2 FUC C4W NAG BMA MAN NAG GAL 13.9535
959 5JWC FAD 13.9918
960 1MFI FHC 14.0351
961 3FGZ BEF 14.0625
962 2ZFU SAH 14.4186
963 1RJW ETF 14.4543
964 2BKX F6R 14.4628
965 5C2N NAG 14.5833
966 2FKA BEF 14.7287
967 5MQ6 NDP 14.8148
968 5T9E NAP 15.1292
969 1MR3 G3D 15.4696
970 1UKG MMA 15.4762
971 1Q8S MAN MMA 15.4762
972 1Q8Q MAN MMA 15.4762
973 2PHU MAN MAN 15.4762
974 2AUY NAG MAN MMA 15.4762
975 1Q8V MAN MAN 15.4762
976 2AR6 NAG MAN 15.4762
977 2AR6 NAG MAN MAN MAN NAG 15.4762
978 2GNM MAN 15.4762
979 1Q8O MAN MMA 15.4762
980 2GMM MAN MAN 15.4762
981 2PHR MAN MAN BMA MAN 15.4762
982 5JCM FAD 15.5211
983 5JCM NAD 15.5211
984 5JCM ISD 15.5211
985 1EJ0 SAM 15.5556
986 6AA8 NAD 15.5629
987 4JNA FAD 15.5882
988 1HYE NAP 15.655
989 5WUW NAP 16.3763
990 6F5Z SAH 16.4502
991 4II2 ATP 16.5644
992 3LXD FAD 16.6265
993 3GCZ SAM 16.6667
994 1WAP TRP 17.3333
995 3CGB FAD 17.5
996 1EDO NAP 17.623
997 4YKG NAD 17.6955
998 4YKG FAD 17.6955
999 5VN0 FAD 18.107
1000 5VN0 NAI