Receptor
PDB id Resolution Class Description Source Keywords
1C39 1.85 Å NON-ENZYME: SIGNAL_HORMONE STRUCTURE OF CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR B PENTAMANNOSYL PHOSPHATE BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECT TRANSPORT SIGNALING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECOGNITION OF PHOSPHORYLATED MANNOSE OLIGOSACCHARIDES BY THE CATION-DEPENDENT MA 6-PHOSPHATE RECEPTOR. J.BIOL.CHEM. V. 274 29889 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MN A:199;
B:199;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
NAG NAG A:201;
B:201;
Part of Protein;
Part of Protein;
none;
none;
submit data
408.404 n/a O=C(N...
P3M A:1200;
B:2200;
Valid;
Valid;
none;
none;
submit data
584.417 C18 H33 O19 P C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTIN TRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Members (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1C39 - P3M C18 H33 O19 P C([C@@H]1[....
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - M6P MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: P3M; Similar ligands found: 137
No: Ligand ECFP6 Tc MDL keys Tc
1 P3M 1 1
2 BGC BGC BGC BGC BGC 0.754386 0.767442
3 BGC BGC BGC ASO BGC BGC ASO 0.754386 0.767442
4 BGC BGC BGC 0.754386 0.767442
5 BGC BGC BGC GLC BGC BGC 0.754386 0.767442
6 GLC BGC BGC BGC 0.754386 0.767442
7 GLC BGC BGC BGC BGC BGC BGC 0.754386 0.767442
8 LB2 0.666667 0.767442
9 MAN GLC 0.666667 0.767442
10 M3M 0.666667 0.767442
11 T6P 0.616667 1
12 BGC BGC GLC 0.584615 0.767442
13 GLA GAL GAL 0.552239 0.767442
14 BMA MAN MAN 0.552239 0.767442
15 GLA GAL BGC 0.552239 0.767442
16 GLC GLC GLC GLC 0.542857 0.767442
17 BGC BGC BGC BGC BGC BGC BGC BGC 0.542857 0.767442
18 BGC BGC BGC BGC 0.542857 0.767442
19 M5S 0.534247 0.767442
20 MAN BMA MAN MAN MAN 0.534247 0.767442
21 GAL GAL SO4 0.528571 0.764706
22 GLA GAL NAG 0.5 0.6
23 MAN BMA NAG 0.5 0.6
24 NAG GAL GAL 0.5 0.6
25 MAN MAN MAN GLC 0.493151 0.767442
26 MDM 0.492308 0.733333
27 GAL MBG 0.492308 0.733333
28 M13 0.492308 0.733333
29 MAN MAN BMA MAN 0.48 0.767442
30 MAN MAN MAN MAN 0.48 0.767442
31 CGC 0.471429 0.727273
32 BG6 0.466667 0.906977
33 BGP 0.466667 0.906977
34 M6P 0.466667 0.906977
35 G6P 0.466667 0.906977
36 A6P 0.466667 0.906977
37 M6D 0.466667 0.906977
38 NGA GAL 0.465753 0.6
39 NAG GAL 0.465753 0.6
40 GAL NAG 0.465753 0.6
41 M6P MAN MAN 0.461538 0.931818
42 GAL NAG GAL BGC 0.457831 0.6
43 BGC GAL NAG GAL 0.457831 0.6
44 LAT NAG GAL 0.457831 0.6
45 BMA BMA MAN 0.455882 0.75
46 GAL NGA GLA BGC GAL 0.453488 0.6
47 GLC GAL NAG GAL 0.447059 0.6
48 2M4 0.446154 0.767442
49 G16 0.446154 0.866667
50 BGC BGC 0.446154 0.767442
51 MAN MAN 0.446154 0.767442
52 NGA GLA GAL BGC 0.44186 0.6
53 ABF 0.440678 0.822222
54 RP5 0.440678 0.822222
55 HSX 0.440678 0.822222
56 MAN MAN MAN BMA MAN 0.439024 0.767442
57 GAL AAL GAL AAL GAL AAL 0.435294 0.702128
58 AAL GAL AAL GAL 0.435294 0.702128
59 AAL GAL AAL GLA 0.435294 0.702128
60 GAL FUC 0.434783 0.727273
61 NAG GAL BGC 0.433735 0.6
62 NAG BMA MAN MAN MAN MAN 0.433333 0.6
63 PRP 0.426471 0.804348
64 MAN MMA MAN 0.421053 0.733333
65 GAL A2G 0.418919 0.6
66 GAL NGA 0.418919 0.6
67 A2G GAL 0.418919 0.6
68 GLA GAL 0.41791 0.767442
69 BGC BMA 0.41791 0.767442
70 BMA BMA 0.41791 0.767442
71 GLC BGC 0.41791 0.767442
72 BGC GAL 0.41791 0.767442
73 GLC GAL 0.41791 0.767442
74 MAB 0.41791 0.767442
75 LBT 0.41791 0.767442
76 N9S 0.41791 0.767442
77 BGC GLC 0.41791 0.767442
78 CBI 0.41791 0.767442
79 GLA GLA 0.41791 0.767442
80 B2G 0.41791 0.767442
81 GAL GLC 0.41791 0.767442
82 CBK 0.41791 0.767442
83 MAL MAL 0.41791 0.75
84 LAT 0.41791 0.767442
85 BMA GAL 0.41791 0.767442
86 GAL BGC 0.41791 0.767442
87 MAL 0.41791 0.767442
88 CT3 0.414286 0.767442
89 BGC GLC GLC GLC GLC 0.414286 0.767442
90 GLC GLC GLC GLC GLC 0.414286 0.767442
91 GLC BGC GLC 0.414286 0.767442
92 GLC GLC GLC GLC GLC GLC GLC 0.414286 0.767442
93 BGC GLC GLC 0.414286 0.767442
94 MAN BMA BMA 0.414286 0.767442
95 MAN MAN BMA BMA BMA BMA 0.414286 0.767442
96 BMA BMA BMA 0.414286 0.767442
97 B4G 0.414286 0.767442
98 DXI 0.414286 0.767442
99 GLC BGC BGC BGC BGC BGC 0.414286 0.767442
100 MAN BMA BMA BMA BMA 0.414286 0.767442
101 CTT 0.414286 0.767442
102 BMA BMA BMA BMA BMA 0.414286 0.767442
103 GLC GAL GAL 0.414286 0.767442
104 GLC GLC BGC 0.414286 0.767442
105 CTR 0.414286 0.767442
106 GLC GLC BGC GLC GLC GLC GLC 0.414286 0.767442
107 CEX 0.414286 0.767442
108 GAL GAL GAL 0.414286 0.767442
109 GLA GAL GLC 0.414286 0.767442
110 GLC GLC GLC GLC GLC GLC GLC GLC 0.414286 0.767442
111 MT7 0.414286 0.767442
112 GLC BGC BGC BGC BGC 0.414286 0.767442
113 CE6 0.414286 0.767442
114 BGC BGC BGC BGC BGC BGC 0.414286 0.767442
115 BMA BMA BMA BMA BMA BMA 0.414286 0.767442
116 BGC GLC GLC GLC GLC GLC GLC 0.414286 0.767442
117 MTT 0.414286 0.767442
118 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.414286 0.767442
119 BMA MAN BMA 0.414286 0.767442
120 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.414286 0.767442
121 GLC BGC BGC 0.414286 0.767442
122 CEY 0.414286 0.767442
123 BGC GLC GLC GLC 0.414286 0.767442
124 CE8 0.414286 0.767442
125 BGC BGC BGC GLC 0.414286 0.767442
126 CE5 0.414286 0.767442
127 MLR 0.414286 0.767442
128 MAN BMA BMA BMA BMA BMA 0.410959 0.75
129 BMA BMA BMA BMA BMA BMA MAN 0.410959 0.75
130 GLC GLC GLC GLC GLC GLC 0.410256 0.767442
131 PPC 0.405797 0.791667
132 47N 0.405405 0.702128
133 AAL GAL 0.405405 0.702128
134 MAN MAN MAN MAN MAN MAN MAN MAN 0.404255 0.708333
135 FUC BGC GAL 0.402597 0.75
136 BMA MAN 0.4 0.711111
137 GLC GLC GLC BGC 0.4 0.767442
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found: 50
This union binding pocket(no: 1) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4ZU4 4TG 0.005937 0.42839 1.35135
2 4P5Z Q7M 0.04868 0.40551 1.97368
3 3AIH BMA MAN MAN 0.000003486 0.58045 2.41935
4 2JF4 VDM 0.01109 0.42381 2.63158
5 2A4W BLM 0.008857 0.43634 2.89855
6 3Q60 ATP 0.0143 0.40914 3.28947
7 1GP6 SIN 0.0252 0.40824 3.28947
8 1GP6 DH2 0.0252 0.40824 3.28947
9 3T7V MD0 0.002264 0.43633 3.94737
10 4KYS VIB 0.01185 0.40141 3.94737
11 1AJS PLA 0.03304 0.40061 3.94737
12 4IGH FMN 0.01879 0.44762 4.60526
13 4IGH ORO 0.01879 0.44762 4.60526
14 4IGH 1EA 0.01879 0.44762 4.60526
15 4X5S AZM 0.003818 0.43269 4.60526
16 1UMZ BGC BGC XYS BGC XYS GAL 0.008148 0.41207 4.60526
17 1TLL FMN 0.02056 0.41142 4.60526
18 1DMY AZM 0.01214 0.40608 5.26316
19 1GQG DCD 0.02661 0.40249 5.26316
20 1PZ1 NAP 0.04066 0.40115 5.26316
21 4Q0L V14 0.01078 0.42758 5.92105
22 1W3T 3GR 0.008329 0.41366 5.92105
23 4C2V YJA 0.02807 0.411 5.92105
24 3MF2 AMP 0.02765 0.40318 5.92105
25 4H2V AMP 0.0269 0.40224 5.92105
26 5EYK 5U5 0.03684 0.40219 5.92105
27 1NN5 ANP 0.04486 0.40121 5.92105
28 3ML5 AZM 0.007962 0.40108 5.92105
29 5OO5 UUA 0.008109 0.42157 6.45161
30 5GQF GAL NAG 0.01101 0.41277 6.57895
31 3CU0 UDP 0.02183 0.40356 6.57895
32 4COQ SAN 0.004149 0.43072 7.23684
33 1HDC CBO 0.01894 0.40848 7.23684
34 4IOK ADP 0.03504 0.40334 7.23684
35 4TMK T5A 0.0459 0.40288 7.23684
36 2CJ9 SSA 0.01946 0.40612 7.89474
37 4MLO PAM 0.01862 0.40131 7.89474
38 5D48 L96 0.03455 0.40236 8.55263
39 4PSB GA3 0.009384 0.44128 9.21053
40 2X4Z X4Z 0.03098 0.41325 9.21053
41 5W4W 9WG 0.02219 0.40968 10.5263
42 4P7X YCP 0.01044 0.41804 11.1842
43 4P7X AKG 0.01044 0.41804 11.1842
44 4N8I COA 0.03337 0.40316 11.1842
45 2VUT NAD 0.0213 0.41061 14.4737
46 3W7T BMA 0.02648 0.40416 14.4737
47 4XQM MAN 0.0000002032 0.51637 21.2766
48 5IH1 GDP 0.02899 0.42742 22.3684
49 5IH1 6BQ 0.02899 0.42742 22.3684
50 1SZ0 M6P 0.000006714 0.50619 34.2105
Pocket No.: 2; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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