Receptor
PDB id Resolution Class Description Source Keywords
1CKA 1.5 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE- CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 D OMAIN OF C-CRK MUS MUSCULUS COMPLEX (ONCOGENE PROTEIN/PEPTIDE)
Ref.: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK. STRUCTURE V. 3 215 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG B:1;
 Valid;
 none;
 Kd = 1.9 uM
916.223 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1CKA 1.5 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE- CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 D OMAIN OF C-CRK MUS MUSCULUS COMPLEX (ONCOGENE PROTEIN/PEPTIDE)
Ref.: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK. STRUCTURE V. 3 215 1995
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 308 families.
1 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
2 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
2 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 40 families.
1 6A9C - LYS VAL ALA PRO PRO ILE PRO HIS ARG n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
4 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
5 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
6 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
7 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
8 2D0N - PRO SER ILE ASP ARG SER THR LYS PRO n/a n/a
9 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
10 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
11 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
12 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
13 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
14 4HXJ Kd ~ 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG; Similar ligands found: 23
No: Ligand ECFP6 Tc MDL keys Tc
1 PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG 1 1
2 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.561404 0.980769
3 PRO PRO LEU ALA SER LYS 0.540323 0.864407
4 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.511811 0.87931
5 PRO PRO LYS LYS LYS ARG LYS VAL 0.488372 0.862069
6 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 0.473214 0.980769
7 PRO PRO LYS ARG ILE ALA 0.471014 0.819672
8 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.460993 0.852459
9 PRO PRO PRO MET ALA GLY GLY 0.44697 0.85
10 LEU PRO PRO VAL VAL ALA LYS GLU ILE 0.441379 0.928571
11 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.438017 0.942308
12 LYS GLY PRO PRO ALA ALA LEU THR LEU 0.424658 0.866667
13 PRO GLU ALA THR ALA PRO PRO GLU GLU 0.421429 0.819672
14 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.415493 0.819672
15 PRO PRO GLY PRO ALA GLY PRO PRO GLY 0.415385 0.875
16 MET PRO PRO PRO PRO SEP PRO CYS THR 0.412214 0.75
17 GLU LEU PRO LEU VAL LYS ILE 0.411348 0.892857
18 MET PRO PRO PRO PRO TPO PRO ARG SER 0.407692 0.761905
19 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.407407 0.796875
20 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.407407 0.813559
21 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.406667 0.83871
22 LEU PRO PRO GLU GLU ARG LEU ILE 0.402778 0.822581
23 5JP PRO LYS ARG ILE ALA 0.4 0.716418
Similar Ligands (3D)
Ligand no: 1; Ligand: PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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