Receptor
PDB id Resolution Class Description Source Keywords
1CKB 1.9 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE- CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 D OMAIN OF C-CRK MUS MUSCULUS COMPLEX (ONCOGENE PROTEIN/PEPTIDE)
Ref.: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK. STRUCTURE V. 3 215 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG B:1;
Valid;
none;
Kd = 5.2 uM
801.027 n/a O=C(N...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1CKA 1.5 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE- CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 D OMAIN OF C-CRK MUS MUSCULUS COMPLEX (ONCOGENE PROTEIN/PEPTIDE)
Ref.: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK. STRUCTURE V. 3 215 1995
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
2 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
2 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG; Similar ligands found: 49
No: Ligand ECFP6 Tc MDL keys Tc
1 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 1 1
2 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.61165 0.859649
3 PRO PRO GLY PRO ARG GLY PRO PRO GLY 0.583333 0.9
4 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.581818 0.949153
5 PRO PRO LYS ARG ILE ALA 0.535433 0.901639
6 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.533835 0.876923
7 LEU PRO PRO GLU GLU ARG LEU ILE 0.527559 0.903226
8 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.512397 0.982759
9 PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG 0.511811 0.87931
10 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.504425 0.862069
11 PRO PRO PRO MET ALA GLY GLY 0.5 0.757576
12 SER PRO ARG LEU PRO LEU LEU GLU SER 0.491935 0.965517
13 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.483607 0.885246
14 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.482517 0.8
15 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 0.481132 0.862069
16 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.479675 0.931035
17 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.461538 0.890625
18 MET PRO PRO PRO PRO TPO PRO ARG SER 0.458333 0.731343
19 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 0.455357 0.836066
20 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.453237 0.904762
21 PRO PRO PRO VAL NMC PRO ARG ARG ARG 0.45082 0.833333
22 DPN PRO DAR ILE NH2 0.448 0.868852
23 DPN PRO DAR DTH NH2 0.448 0.8
24 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.440298 0.757576
25 MET PRO PRO PRO PRO SEP PRO CYS THR 0.439024 0.720588
26 SER PRO LYS ARG ILE ALA 0.4375 0.84375
27 5JP PRO LYS ARG ILE ALA 0.434426 0.830769
28 ACE PRO PRO PRO VAL IPG PRO ARG ARG 0.433071 0.933333
29 ACE GLN GLU ARG GLU VAL PRO CYS 0.431818 0.887097
30 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.431507 0.904762
31 GLY MET PRO ARG GLY ALA 0.430769 0.818182
32 CYS THR PRO SER ARG 0.428571 0.80303
33 THR PRO ARG VAL THR GLY GLY GLY ALA MET 0.427586 0.788732
34 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.427536 0.820895
35 PRO GLU ALA THR ALA PRO PRO GLU GLU 0.425373 0.757576
36 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.423358 0.846154
37 THR PRO ARG ARG SER MLZ SER ALA 0.423077 0.797101
38 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.416667 0.78125
39 DPN PRO DAR CYS NH2 0.412698 0.836066
40 MET CYS PRO ARG MET THR ALA VAL MET 0.412162 0.811594
41 PRO SER ARG VAL 0.408696 0.75
42 PHE ASN ARG PRO VAL 0.407407 0.830769
43 ARG PRO LYS ARG ILE ALA 0.407407 0.901639
44 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.406667 0.904762
45 PRO PRO PRO PRO PRO PRO PRO PRO IYR 0.406504 0.671429
46 PRO THR PRO SER ALA PRO VAL PRO LEU 0.404762 0.761194
47 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.40411 0.876923
48 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.401408 0.863636
49 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.4 0.901639
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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