Receptor
PDB id Resolution Class Description Source Keywords
1DDV 1.9 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE RATTUS NORVEGICUS PROTEIN-LIGAND COMPLEX POLYPROLINE RECOGNITION BETA TURN SIGNALING PROTEIN
Ref.: STRUCTURE OF THE HOMER EVH1 DOMAIN-PEPTIDE COMPLEX REVEALS A NEW TWIST IN POLYPROLINE RECOGNITION. NEURON V. 26 143 2000
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
THR PRO PRO SER PRO PHE B:1001;
Valid;
none;
submit data
644.726 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1DDV 1.9 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE RATTUS NORVEGICUS PROTEIN-LIGAND COMPLEX POLYPROLINE RECOGNITION BETA TURN SIGNALING PROTEIN
Ref.: STRUCTURE OF THE HOMER EVH1 DOMAIN-PEPTIDE COMPLEX REVEALS A NEW TWIST IN POLYPROLINE RECOGNITION. NEURON V. 26 143 2000
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1DDV - THR PRO PRO SER PRO PHE n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: THR PRO PRO SER PRO PHE; Similar ligands found: 46
No: Ligand ECFP6 Tc MDL keys Tc
1 THR PRO PRO SER PRO PHE 1 1
2 TYR MET ASP PHE ASP ASP ASP ILE PRO PHE 0.62766 0.766667
3 01B PRO PRO ALA NH2 0.543689 0.864407
4 TRP ASP ILE PRO PHE 0.527778 0.786885
5 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.527778 0.786885
6 LYS THR PHE PRO PRO THR GLU PRO LYS 0.511278 0.916667
7 ACE PRO ALA PRO PHE 0.504505 0.833333
8 ALA THR PRO PHE GLN GLU 0.495238 0.87931
9 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.492647 0.820895
10 GLY SER ASP PRO PHE LYS 0.491525 0.915254
11 TYR PRO TYR 0.485149 0.803279
12 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.481481 0.753623
13 LEU SER SER PRO VAL THR LYS SER PHE 0.480916 0.918033
14 DPN PRO ARG 0.458716 0.734375
15 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.457364 0.875
16 LEU ASN PHE PRO ILE SER PRO 0.448819 0.861538
17 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.448529 0.888889
18 PHE ASN PHE PRO GLN ILE THR 0.442748 0.80303
19 GLU PHE SER PRO 0.436364 0.896552
20 SER ASP ILE LEU PHE PRO ALA ASP SER 0.43609 0.857143
21 DPN PRO DAR DTH NH2 0.433333 0.8125
22 PHE SER HIS PRO GLN ASN THR 0.42446 0.890625
23 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 0.423423 0.881356
24 ALA DAL PRO PHE NIT 0.421488 0.666667
25 PHE ASN ARG PRO VAL 0.420635 0.724638
26 ARG VAL SER PRO SER THR SER TYR THR PRO 0.420635 0.887097
27 TYR SEP PRO THR SEP PRO SER 0.420635 0.850746
28 ACE PRO ALA PRO TYR 0.420168 0.83871
29 PRO PRO PRO PRO PRO PRO PRO PRO IYR 0.418803 0.796875
30 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.417266 0.818182
31 ILE THR ASP GLN VAL PRO PHE SER VAL 0.416667 0.859375
32 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.416107 0.838235
33 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.414474 0.833333
34 ACE PHE PRO PRO PRO PRO THR 0.414414 0.741379
35 TYR PRO PHE PHE NH2 0.413793 0.803279
36 MIN 0.412844 0.709677
37 LEU PRO PHE GLU LYS SER THR VAL MET 0.412162 0.848485
38 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.407692 0.854839
39 MAA LYS PRO PHE 0.40678 0.779661
40 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.402778 0.716216
41 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.402685 0.835821
42 PHE SER ALA PTR PRO SER GLU GLU ASP 0.401361 0.8
43 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.4 0.790323
44 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.4 0.797101
45 LEU PHE GLY TYR PRO VAL TYR VAL 0.4 0.8
46 SER SER PHE TYR PRO SEP ALA GLU GLY 0.4 0.797101
Similar Binding Sites (Proteins are less than 50% similar to leader)
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