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Receptor
PDB id Resolution Class Description Source Keywords
1DDV 1.9 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR RATTUS NORVEGICUS PROTEIN-LIGAND COMPLEX POLYPROLINE RECOGNITION BETA TURN PROTEIN
Ref.: STRUCTURE OF THE HOMER EVH1 DOMAIN-PEPTIDE COMPLEX NEW TWIST IN POLYPROLINE RECOGNITION. NEURON V. 26 143 2000
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
THR PRO PRO SER PRO PHE B:1001;
Valid;
none;
submit data
644.726 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1DDV 1.9 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR RATTUS NORVEGICUS PROTEIN-LIGAND COMPLEX POLYPROLINE RECOGNITION BETA TURN PROTEIN
Ref.: STRUCTURE OF THE HOMER EVH1 DOMAIN-PEPTIDE COMPLEX NEW TWIST IN POLYPROLINE RECOGNITION. NEURON V. 26 143 2000
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 1DDV - THR PRO PRO SER PRO PHE n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 1I7A - PHE C9 H11 N O2 c1ccc(cc1)....
2 1DDV - THR PRO PRO SER PRO PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: THR PRO PRO SER PRO PHE; Similar ligands found: 72
No: Ligand ECFP6 Tc MDL keys Tc
1 THR PRO PRO SER PRO PHE 1 1
2 TYR MET ASP PHE ASP ASP ASP ILE PRO PHE 0.644444 0.786885
3 ACE PRO ALA PRO PHE 0.583333 0.819672
4 01B PRO PRO ALA NH2 0.583333 0.9
5 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.548077 0.806452
6 TRP ASP ILE PRO PHE 0.548077 0.806452
7 HIS PRO PHE 0.539216 0.790323
8 LYS THR PHE PRO PRO THR GLU PRO LYS 0.51938 0.934426
9 ALA THR PRO PHE GLN GLU 0.514852 0.881356
10 PRO PHQ PHE 0.510417 0.730159
11 GLY SER ASP PRO PHE LYS 0.491379 0.916667
12 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.488889 0.835821
13 LEU ASN PHE PRO ILE SER PRO 0.483333 0.876923
14 ACE PRO ALA PRO TYR 0.480769 0.825397
15 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.477612 0.768116
16 ACE PHE PRO PRO PRO PRO THR 0.466667 0.762712
17 DPN PRO ARG 0.462963 0.75
18 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.460938 0.876923
19 LEU PRO SER PHE GLU THR ALA LEU 0.458015 0.888889
20 GLU PHE SER PRO 0.457944 0.898305
21 PHE ASN PHE PRO GLN ILE THR 0.453125 0.818182
22 SER ASP ILE LEU PHE PRO ALA ASP SER 0.449612 0.859375
23 TYR PRO PHE PHE NH2 0.449541 0.806452
24 LEU SER SER PRO VAL THR LYS SER PHE 0.447761 0.903226
25 PRO PRO PRO PRO PRO PRO PRO PRO IYR 0.446429 0.815385
26 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.445255 0.779412
27 ALA DAL PRO PHE NIT 0.443478 0.671233
28 DPN PRO DAR DTH NH2 0.440678 0.815385
29 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.440298 0.890625
30 PHE SER ALA PTR PRO SER GLU GLU ASP 0.438462 0.8
31 ARG THR PHE SER PRO THR TYR GLY LEU 0.4375 0.780822
32 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.435374 0.848485
33 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.433071 0.887097
34 MIN 0.428571 0.725806
35 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.427586 0.84058
36 ARG VAL SER PRO SER THR SER TYR THR PRO 0.42623 0.888889
37 LEU PHE GLY TYR PRO VAL TYR VAL 0.425373 0.80303
38 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.42446 0.72973
39 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.424 0.857143
40 PRO ALA PRO PHE ALA SER ALA 0.424 0.901639
41 TYR SEP PRO THR SEP PRO SER 0.422764 0.852941
42 SER PRO ILE VAL PRO SER PHE ASP MET 0.421429 0.838235
43 LEU PRO PHE GLU LYS SER THR VAL MET 0.42069 0.850746
44 PHE ASN ARG PRO VAL 0.420635 0.73913
45 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 0.420561 0.883333
46 ILE THR ASP GLN VAL PRO PHE SER VAL 0.41844 0.875
47 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.41844 0.811594
48 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.416667 0.833333
49 DPN PRO DAR CYS NH2 0.415254 0.712121
50 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.414966 0.850746
51 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.412587 0.753425
52 ACE PHE HIS PRO ALA NH2 0.411765 0.765625
53 MAA LYS PRO PHE 0.410256 0.816667
54 MAA LPH PRO PHE 4LZ 0.410072 0.72973
55 SIN ALA LEU PRO PHE NIT 0.407692 0.657895
56 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.407143 0.80303
57 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.407143 0.80303
58 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.405594 0.83871
59 1IP CYS PHE SER LYS PRO ARG 0.405594 0.811594
60 DPN PRO DAR ILE NH2 0.404959 0.716418
61 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.40458 0.809524
62 LEU PRO PHE ASP LYS SER THR ILE MET 0.403974 0.838235
63 ALA PRO THR 0.402174 0.8
64 PRO ALA PRO PHE ALA ALA ALA 0.401639 0.833333
65 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.401639 0.80597
66 ASN TRP SER HIS PRO GLN PHE GLU LYS 0.401575 0.84375
67 ALA PRO GLN PRO ALA PRO GLU ASN ALA TYR 0.40146 0.846154
68 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.401408 0.875
69 ALA PHE ARG ILE PRO LEU THR ARG 0.401408 0.811594
70 ALA CYS SEP PRO GLN PHE GLY 0.4 0.779412
71 VAL PRO LEU ARG PRO MET THR TYR 0.4 0.77027
72 PRO SER TYR SEP PRO THR SEP PRO SER 0.4 0.852941
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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