Receptor
PDB id Resolution Class Description Source Keywords
1EJ4 2.25 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE MUS MUSCULUS EIF4E/4E-BP/7-METHYL-GDP TRANSLATION
Ref.: CAP-DEPENDENT TRANSLATION INITIATION IN EUKARYOTES REGULATED BY A MOLECULAR MIMIC OF EIF4G. MOL.CELL V. 3 707 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
M7G A:1000;
Valid;
none;
submit data
459.243 C11 H19 N5 O11 P2 CN1CN...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1EJ4 2.25 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE MUS MUSCULUS EIF4E/4E-BP/7-METHYL-GDP TRANSLATION
Ref.: CAP-DEPENDENT TRANSLATION INITIATION IN EUKARYOTES REGULATED BY A MOLECULAR MIMIC OF EIF4G. MOL.CELL V. 3 707 1999
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 1WKW - GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
2 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
3 2V8W Kd = 0.146 uM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
4 2V8Y Kd = 1.96 uM MGV C17 H20 F N5 O8 P c1cc(ccc1C....
5 2V8X Kd = 6.95 uM MGQ C17 H21 N5 O8 P c1ccc(cc1)....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1WKW - GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
2 3HXG Kd = 0.27 uM GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
3 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
4 2V8W Kd = 0.146 uM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
5 2V8Y Kd = 1.96 uM MGV C17 H20 F N5 O8 P c1cc(ccc1C....
6 2V8X Kd = 6.95 uM MGQ C17 H21 N5 O8 P c1ccc(cc1)....
7 3M94 - M7M C13 H23 N5 O11 P2 CN1CN(C2=C....
8 2JGB Ka = 410000 M^-1 MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: M7G; Similar ligands found: 11
No: Ligand ECFP6 Tc MDL keys Tc
1 M7G 1 1
2 MGT 0.910256 1
3 M7M 0.541667 0.963855
4 G8D 0.537634 0.914634
5 TPG 0.525 0.920455
6 8GT 0.494845 0.914634
7 CDP 0.43617 0.829268
8 UDP 0.430108 0.780488
9 8GM 0.412371 0.902439
10 8OD 0.411765 0.77907
11 8GD 0.407767 0.872093
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1EJ4; Ligand: M7G; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1ej4.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
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