Receptor
PDB id Resolution Class Description Source Keywords
1FZG 2.5 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF FRAGMENT D FROM HUMAN FIBRINOGEN WITH T LIGAND GLY-HIS-ARG-PRO-AMIDE HOMO SAPIENS BLOOD COAGULATION PLASMA PLATELET FIBRINOGEN FIBRIN
Ref.: CONFORMATIONAL CHANGES IN FRAGMENTS D AND DOUBLE-D HUMAN FIBRIN(OGEN) UPON BINDING THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE. BIOCHEMISTRY V. 38 2941 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA B:2;
B:3;
C:1;
C:4;
E:2;
E:3;
F:1;
F:4;
 Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
none;
none;
none;
none;
none;
 submit data
40.078 Ca [Ca+2...
GLY HIS ARG PRO M:1;
N:1;
S:1;
T:1;
 Valid;
Valid;
Valid;
Valid;
 none;
none;
none;
none;
 submit data
466.523 n/a O=C(N...
NAG NAG H:1;
G:1;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
408.404 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3E1I 2.3 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BBETAD432A VARIANT FIBRINOGEN FRAGMENT PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE HOMO SAPIENS BLOOD COAGULATION DISEASE MUTATION GLYCOPROTEIN PHOSPHOPRSECRETED PYRROLIDONE CARBOXYLIC ACID SULFATION BLOOD CLO
Ref.: FIBRINOGEN VARIANT BBETAD432A HAS NORMAL POLYMERIZA DOES NOT BIND KNOB "B". BLOOD V. 113 4425 2009
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 1FZG - GLY HIS ARG PRO n/a n/a
2 1FZC - GLY HIS ARG PRO n/a n/a
3 3E1I - GLY HIS ARG PRO NH2 n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 1RE3 - GLY HIS ARG PRO n/a n/a
2 2OYH - GLY HIS ARG PRO n/a n/a
3 1FZG - GLY HIS ARG PRO n/a n/a
4 1FZC - GLY HIS ARG PRO n/a n/a
5 3E1I - GLY HIS ARG PRO NH2 n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 1FZG - GLY HIS ARG PRO n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLY HIS ARG PRO; Similar ligands found: 40
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY HIS ARG PRO 1 1
2 GLY HIS ARG PRO NH2 0.752577 0.966102
3 GLY PHE ARG PRO 0.701031 0.916667
4 SER HIS PRO ARG PRO ILE ARG VAL 0.522727 0.828571
5 GLY PHE GLU PRO 0.504762 0.816667
6 LYS ARG ARG ARG HIS PRO SER 0.503937 0.904762
7 LYS ARG ARG ARG HIS PRO SER GLY 0.5 0.892308
8 HIS HIS ALA SER PRO ARG LYS 0.492647 0.876923
9 HIS PRO 0.478723 0.864407
10 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.478571 0.90625
11 LEU PRO PHE GLU LEU ARG GLY HIS LEU VAL 0.47651 0.907692
12 GLY ALA ARG ALA HIS SER SER 0.474576 0.75
13 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.471831 0.907692
14 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.455696 0.867647
15 GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 0.451128 0.815385
16 GLY ASP CYS PHE SER LYS PRO ARG 0.450704 0.835821
17 ALA ARG SER HIS SEP TYR PRO ALA 0.449664 0.730769
18 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.449275 0.828571
19 PHE ASN ARG PRO VAL 0.440945 0.861538
20 SER ARG ASP HIS SER ARG THR PRO MET 0.44 0.808219
21 GLY MET PRO ARG GLY ALA 0.439024 0.791045
22 ARG LEU TYR HIS SEP LEU PRO ALA 0.437086 0.721519
23 SER THR GLY GLY VAL M3L LYS PRO HIS ARG 0.432927 0.763158
24 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.431507 0.84375
25 LYS PRO HIS SER ASP 0.428571 0.830769
26 MET TRP ARG PRO TRP 0.425532 0.797101
27 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.425 0.921875
28 ACE TRP ARG VAL PRO 0.423077 0.863636
29 ACE PHE HIS PRO ALA NH2 0.421488 0.78125
30 GLY HIS GLY 0.421053 0.711864
31 THR LYS PRO ARG 0.418182 0.898305
32 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.41791 0.80597
33 ARG SER HIS SEP SER PRO ALA SER LEU GLN 0.417722 0.773333
34 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.413333 0.811594
35 ALA LYS PHE ARG HIS ASP 0.410853 0.825397
36 PCA PHE ARG HIS ASP SER 0.407407 0.825397
37 GLY ARG LEU LEU PRO 0.405172 0.825397
38 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.401408 0.739726
39 GLY PRO ARG PRO 0.4 0.883333
40 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.4 0.782609
Similar Ligands (3D)
Ligand no: 1; Ligand: GLY HIS ARG PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3E1I; Ligand: NAG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3e1i.bio2) has 2 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3E1I; Ligand: NAG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3e1i.bio1) has 1 residues
No: Leader PDB Ligand Sequence Similarity
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