Receptor
PDB id Resolution Class Description Source Keywords
1H2K 2.15 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FR PEPTIDE HOMO SAPIENS TRANSCRIPTION ACTIVATOR-INHIBITOR COMPLEX FIH HIF DSBH OTRANSCRIPTION HYPOXIA 2- OXOGLUTARATE ASPARAGINYL HYDROXPHOSPHORYLATION
Ref.: STRUCTURE OF FACTOR-INHIBITING HYPOXIA-INDUCIBLE FA (HIF) REVEALS MECHANISM OF OXIDATIVE MODIFICATION O HIF-1ALPHA J.BIOL.CHEM. V. 278 1802 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FE2 A:1350;
Part of Protein;
none;
submit data
55.845 Fe [Fe+2...
OGA A:1351;
Valid;
none;
submit data
147.086 C4 H5 N O5 C(C(=...
SO4 A:1352;
A:1353;
Invalid;
Invalid;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1H2K 2.15 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FR PEPTIDE HOMO SAPIENS TRANSCRIPTION ACTIVATOR-INHIBITOR COMPLEX FIH HIF DSBH OTRANSCRIPTION HYPOXIA 2- OXOGLUTARATE ASPARAGINYL HYDROXPHOSPHORYLATION
Ref.: STRUCTURE OF FACTOR-INHIBITING HYPOXIA-INDUCIBLE FA (HIF) REVEALS MECHANISM OF OXIDATIVE MODIFICATION O HIF-1ALPHA J.BIOL.CHEM. V. 278 1802 2003
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 1H2K - OGA C4 H5 N O5 C(C(=O)O)N....
2 1H2L - AKG C5 H6 O5 C(CC(=O)O)....
3 2ILM - AKG C5 H6 O5 C(CC(=O)O)....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1H2M - OGA C4 H5 N O5 C(C(=O)O)N....
2 1H2K - OGA C4 H5 N O5 C(C(=O)O)N....
3 1H2L - AKG C5 H6 O5 C(CC(=O)O)....
4 2ILM - AKG C5 H6 O5 C(CC(=O)O)....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1H2M - OGA C4 H5 N O5 C(C(=O)O)N....
2 1H2K - OGA C4 H5 N O5 C(C(=O)O)N....
3 1H2L - AKG C5 H6 O5 C(CC(=O)O)....
4 2ILM - AKG C5 H6 O5 C(CC(=O)O)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OGA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OGA 1 1
2 AAC 0.461538 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1H2K; Ligand: OGA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1h2k.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1H2K; Ligand: OGA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1h2k.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
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