Receptor
PDB id Resolution Class Description Source Keywords
1H2T 2.1 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN WITH A CAP ANALOGUE M7GPPPG HOMO SAPIENS M7GCAP CAP-BINDING-COMPLEX RNP DOMAIN MIF4G DOMAIN RNA MATURATION RNA EXPORT NUCLEAR PROTEIN RNA-BINDING
Ref.: LARGE-SCALE INDUCED FIT RECOGNITION OF AN M(7)GPPPG ANALOGUE BY THE HUMAN NUCLEAR CAP-BINDING COMPLEX EMBO J. V. 21 5548 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP 7MG Z:1151;
Valid;
none;
Kd ~ 13 nM
800.421 n/a [P+](...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1H2T 2.1 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN WITH A CAP ANALOGUE M7GPPPG HOMO SAPIENS M7GCAP CAP-BINDING-COMPLEX RNP DOMAIN MIF4G DOMAIN RNA MATURATION RNA EXPORT NUCLEAR PROTEIN RNA-BINDING
Ref.: LARGE-SCALE INDUCED FIT RECOGNITION OF AN M(7)GPPPG ANALOGUE BY THE HUMAN NUCLEAR CAP-BINDING COMPLEX EMBO J. V. 21 5548 2002
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 257 families.
1 1H2T Kd ~ 13 nM GDP 7MG n/a n/a
2 1H2U Kd ~ 13 nM GDP 7MG n/a n/a
3 1N52 - GTG C21 H30 N10 O18 P3 C[n+]1cn(c....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 222 families.
1 1H2T Kd ~ 13 nM GDP 7MG n/a n/a
2 1H2U Kd ~ 13 nM GDP 7MG n/a n/a
3 1N52 - GTG C21 H30 N10 O18 P3 C[n+]1cn(c....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 185 families.
1 1H2T Kd ~ 13 nM GDP 7MG n/a n/a
2 1H2U Kd ~ 13 nM GDP 7MG n/a n/a
3 1N52 - GTG C21 H30 N10 O18 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP 7MG; Similar ligands found: 100
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 7MG 1 1
2 GTG 0.79798 0.974684
3 GTP MG 0.768421 0.9125
4 GDP MG 0.726316 0.9125
5 GDP BEF 0.71875 0.890244
6 GDP AF3 0.71 0.879518
7 GDP ALF 0.71 0.879518
8 BEF GDP 0.69697 0.879518
9 ALF 5GP 0.666667 0.879518
10 GDP 0.636364 0.911392
11 5GP 0.635417 0.923077
12 G 0.635417 0.923077
13 GP3 0.626263 0.936709
14 G7M 0.625 0.961538
15 GP2 0.62 0.878049
16 GNH 0.613861 0.9
17 G G 0.611111 0.974026
18 GCP G 0.609524 0.924051
19 G2P 0.605769 0.878049
20 GTP 0.601942 0.911392
21 G1R 0.596154 0.9
22 GCP 0.596154 0.888889
23 MGP 0.592233 0.949367
24 GNP 0.590476 0.888889
25 GSP 0.590476 0.86747
26 6G0 0.586538 0.949367
27 GMV 0.586538 0.888889
28 GAV 0.579439 0.878049
29 G2R 0.563636 0.878049
30 G1R G1R 0.5625 0.9375
31 Y9Z 0.552632 0.848837
32 GFB 0.547826 0.925
33 GDR 0.547826 0.925
34 GTA 0.547009 0.974684
35 PGD O 0.546154 0.822222
36 GPG 0.544643 0.925
37 YGP 0.54386 0.891566
38 GDC 0.53913 0.901235
39 GKE 0.53913 0.901235
40 GDD 0.53913 0.901235
41 GMP 0.536842 0.822785
42 JB2 0.533898 0.925
43 GKD 0.533898 0.901235
44 G3A 0.529915 0.936709
45 6CK 0.529915 0.879518
46 GPD 0.529412 0.891566
47 NGD 0.528455 0.949367
48 MG7 0.526316 0.860759
49 G5P 0.525424 0.936709
50 I2C FE2 CMO CMO 0.523438 0.842697
51 U A G G 0.519685 0.974026
52 GDX 0.516667 0.9125
53 G A A A 0.511811 0.961538
54 JB3 0.508065 0.91358
55 G3D 0.504505 0.898734
56 FEG 0.504 0.892857
57 ZGP 0.5 0.882353
58 G4P 0.495575 0.898734
59 CAG 0.492308 0.894118
60 3GP 0.490385 0.886076
61 CG2 0.484375 0.879518
62 G G U 0.483607 0.948718
63 2MD 0.48062 0.83908
64 U2G 0.480315 0.879518
65 0O2 0.478632 0.898734
66 MD1 0.477612 0.83908
67 MGD 0.469697 0.83908
68 G C 0.469231 0.91358
69 TPG 0.459854 0.833333
70 DBG 0.459854 0.91358
71 FE9 0.459259 0.789474
72 PGD 0.455882 0.869048
73 2GP 0.448598 0.875
74 G G G C 0.448529 0.925926
75 BGO 0.446154 0.9375
76 U G A 0.442177 0.925926
77 GPX 0.440678 0.8625
78 G4M 0.438356 0.872093
79 G G G RPC 0.43609 0.9125
80 A G C C 0.434783 0.925
81 G C C C 0.432624 0.91358
82 ADP PO3 0.428571 0.883117
83 GGM 0.425373 0.914634
84 ATP MG 0.424779 0.85
85 GH3 0.423729 0.8875
86 APC G U 0.423358 0.924051
87 DGI 0.421053 0.843373
88 G1G 0.42029 0.9625
89 MGQ 0.420168 0.949367
90 DG DG 0.418033 0.902439
91 P2G 0.414414 0.82716
92 OMC OMU OMG OMG U 0.410596 0.950617
93 MGV 0.409836 0.903614
94 P1G 0.40708 0.817073
95 DGT 0.40678 0.843373
96 A G U 0.406667 0.925926
97 DG 0.405405 0.853659
98 DGP 0.405405 0.853659
99 IDP 0.403509 0.886076
100 4TA 0.40146 0.825581
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1H2T; Ligand: GDP 7MG; Similar sites found: 13
This union binding pocket(no: 1) in the query (biounit: 1h2t.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4LH7 1X8 0.009495 0.42451 3.84615
2 4CC6 L5Y 0.0142 0.40483 3.84615
3 5UQD AKG 0.02206 0.40443 4.0724
4 3CMJ SRT 0.001835 0.45554 4.08602
5 5FAL SKT 0.03631 0.41076 5.76923
6 5FAL COA 0.03631 0.41076 5.76923
7 4PZ6 GMP 0.003969 0.44075 6.41026
8 2CBZ ATP 0.02946 0.40207 6.75105
9 2Q7D ANP 0.01532 0.40146 6.93642
10 4GLW 0XT 0.01723 0.40069 7.05128
11 3QTP 2PG 0.01299 0.40673 11.5385
12 2G30 ALA ALA PHE 0.01184 0.41569 18.75
13 3LQV ADE 0.0005771 0.51421 34.7826
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