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Receptor
PDB id Resolution Class Description Source Keywords
1H2T 2.1 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN WITH A CAP ANALOGUE M7GPPPG HOMO SAPIENS M7GCAP CAP-BINDING-COMPLEX RNP DOMAIN MIF4G DOMAIN RNA MATURATION RNA EXPORT NUCLEAR PROTEIN RNA-BINDING
Ref.: LARGE-SCALE INDUCED FIT RECOGNITION OF AN M(7)GPPPG ANALOGUE BY THE HUMAN NUCLEAR CAP-BINDING COMPLEX EMBO J. V. 21 5548 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP 7MG Z:1151;
Valid;
none;
Kd ~ 13 nM
800.421 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1H2T 2.1 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN WITH A CAP ANALOGUE M7GPPPG HOMO SAPIENS M7GCAP CAP-BINDING-COMPLEX RNP DOMAIN MIF4G DOMAIN RNA MATURATION RNA EXPORT NUCLEAR PROTEIN RNA-BINDING
Ref.: LARGE-SCALE INDUCED FIT RECOGNITION OF AN M(7)GPPPG ANALOGUE BY THE HUMAN NUCLEAR CAP-BINDING COMPLEX EMBO J. V. 21 5548 2002
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 1H2T Kd ~ 13 nM GDP 7MG n/a n/a
2 1H2U Kd ~ 13 nM GDP 7MG n/a n/a
3 1N52 - GTG C21 H30 N10 O18 P3 C[n+]1cn(c....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 1H2T Kd ~ 13 nM GDP 7MG n/a n/a
2 1H2U Kd ~ 13 nM GDP 7MG n/a n/a
3 1N52 - GTG C21 H30 N10 O18 P3 C[n+]1cn(c....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1H2T Kd ~ 13 nM GDP 7MG n/a n/a
2 1H2U Kd ~ 13 nM GDP 7MG n/a n/a
3 1N52 - GTG C21 H30 N10 O18 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP 7MG; Similar ligands found: 97
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 7MG 1 1
2 GTG 0.79798 0.974684
3 GDP AF3 0.71 0.879518
4 GDP ALF 0.71 0.879518
5 ALF GDP 0.71 0.879518
6 ALF 5GP 0.666667 0.879518
7 GDP 0.636364 0.911392
8 5GP 0.635417 0.923077
9 G 0.635417 0.923077
10 GP3 0.626263 0.936709
11 G7M 0.625 0.961538
12 GP2 0.62 0.878049
13 GNH 0.613861 0.9
14 G2P 0.605769 0.878049
15 G G 0.603604 0.961538
16 GTP 0.601942 0.911392
17 G1R 0.596154 0.9
18 GCP 0.596154 0.888889
19 MGP 0.592233 0.949367
20 GNP 0.590476 0.888889
21 GSP 0.590476 0.86747
22 9GM 0.590476 0.888889
23 6G0 0.586538 0.949367
24 GMV 0.586538 0.888889
25 GAV 0.579439 0.878049
26 G2R 0.563636 0.878049
27 G1R G1R 0.5625 0.9375
28 Y9Z 0.552632 0.848837
29 GFB 0.547826 0.925
30 GDR 0.547826 0.925
31 GTA 0.547009 0.974684
32 PGD O 0.546154 0.822222
33 GPG 0.544643 0.925
34 YGP 0.54386 0.891566
35 GCP G 0.539823 0.910256
36 GDD 0.53913 0.901235
37 GKE 0.53913 0.901235
38 GDC 0.53913 0.901235
39 GMP 0.536842 0.822785
40 GKD 0.533898 0.901235
41 JB2 0.533898 0.925
42 G3A 0.529915 0.936709
43 6CK 0.529915 0.879518
44 GPD 0.529412 0.891566
45 NGD 0.528455 0.949367
46 MG7 0.526316 0.860759
47 G5P 0.525424 0.936709
48 A G 0.52381 0.974026
49 U A G G 0.519685 0.974026
50 GDX 0.516667 0.9125
51 G A A A 0.511811 0.961538
52 JB3 0.508065 0.91358
53 G3D 0.504505 0.898734
54 FEG 0.504 0.892857
55 ZGP 0.5 0.882353
56 G4P 0.495575 0.898734
57 CAG 0.492308 0.894118
58 3GP 0.490385 0.886076
59 CG2 0.484375 0.879518
60 2MD 0.48062 0.83908
61 U2G 0.480315 0.879518
62 AKW 0.480315 0.926829
63 0O2 0.478632 0.898734
64 MD1 0.477612 0.83908
65 G U 0.476562 0.91358
66 MGD 0.469697 0.83908
67 G C 0.469231 0.91358
68 DBG 0.459854 0.91358
69 TPG 0.459854 0.833333
70 FE9 0.459259 0.789474
71 PGD 0.455882 0.869048
72 AJQ 0.453846 0.926829
73 2GP 0.448598 0.875
74 G G G C 0.448529 0.925926
75 BGO 0.446154 0.9375
76 GPX 0.440678 0.8625
77 G4M 0.438356 0.872093
78 G G G RPC 0.43609 0.9125
79 A G C C 0.434783 0.925
80 G C C C 0.432624 0.91358
81 ADP PO3 0.428571 0.883117
82 GGM 0.425373 0.914634
83 GH3 0.423729 0.8875
84 APC G U 0.423358 0.924051
85 DGI 0.421053 0.843373
86 G1G 0.42029 0.9625
87 MGQ 0.420168 0.949367
88 DG DG 0.418033 0.902439
89 P2G 0.414414 0.82716
90 MGV 0.409836 0.903614
91 P1G 0.40708 0.817073
92 DGT 0.40678 0.843373
93 A G U 0.406667 0.925926
94 DG 0.405405 0.853659
95 DGP 0.405405 0.853659
96 IDP 0.403509 0.886076
97 4TA 0.40146 0.825581
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1H2T; Ligand: GDP 7MG; Similar sites found with APoc: 35
This union binding pocket(no: 1) in the query (biounit: 1h2t.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5H9Y BGC BGC BGC BGC BGC 2.5641
2 5BOE PEP 3.84615
3 4LH7 1X8 3.84615
4 4CC6 L5Y 3.84615
5 1T9D FAD 3.84615
6 5WKC FAD 3.84615
7 5UQD AKG 4.0724
8 3CMJ SRT 4.08602
9 5EO8 TFU 5.12821
10 3T1A 5MA 5.12821
11 2IO8 ADP 5.12821
12 3WUD GLC GAL 5.14706
13 4PZ6 GMP 6.41026
14 2FB3 MET 6.47059
15 2CBZ ATP 6.75105
16 5C1P ADP 6.86275
17 2Q7D ANP 6.93642
18 1DKU AP2 6.94006
19 4GLW 0XT 7.05128
20 1QF5 RPL 7.19258
21 1QF5 GDP 7.19258
22 3CV6 NAP 7.43034
23 3CV6 HXS 7.43034
24 4JJF N2I 8.43023
25 1SWG BTN 9.375
26 5VGS 9A7 10.828
27 4URS C2E 10.8974
28 3TM0 ANP 10.8974
29 3TM0 B31 10.8974
30 3QTP 2PG 11.5385
31 2V58 LZJ 11.5385
32 6C1S EFV 12.1795
33 5DZT AMP 18.5897
34 2G30 ALA ALA PHE 18.75
35 3LQV ADE 34.7826
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