Receptor
PDB id Resolution Class Description Source Keywords
1I31 2.5 Å NON-ENZYME: OTHER MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION RATTUS NORVEGICUS BETA-SANDWICH PEPTIDE-BINDING SITE PROTEIN-PEPTIDE COMPLEX CLATHRIN ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION TO BE PUBLISHED
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PHE TYR ARG ALA LEU MET P:1;
Valid;
none;
submit data
801.003 n/a S(CCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1I31 2.5 Å NON-ENZYME: OTHER MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION RATTUS NORVEGICUS BETA-SANDWICH PEPTIDE-BINDING SITE PROTEIN-PEPTIDE COMPLEX CLATHRIN ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION TO BE PUBLISHED
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 1I31 - PHE TYR ARG ALA LEU MET n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PHE TYR ARG ALA LEU MET; Similar ligands found: 175
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE TYR ARG ALA LEU MET 1 1
2 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.716667 0.885246
3 PHE ARG TYR LEU GLY 0.675439 0.9
4 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.674419 0.885246
5 GLU LEU ARG ARG LYS MET MET TYR MET 0.658537 0.903226
6 PHE LEU ALA TYR LYS 0.640351 0.813559
7 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.630631 0.844828
8 ASN ALA LEU LEU ARG TYR LEU LEU ASP 0.614754 0.825397
9 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.606061 0.857143
10 GLU LEU LYS ARG LYS MET ILE TYR MET 0.6 0.903226
11 SER LEU ARG PHE LEU TYR GLU GLY 0.59375 0.84375
12 ARG VAL LEU PHE GLU ALA MET 0.592308 0.836066
13 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.569444 0.830769
14 GLU LEU ASN ARG LYS MET ILE TYR MET 0.5625 0.861538
15 PHE LEU SER TYR LYS 0.558333 0.761905
16 PHE GLU ASP LEU ARG LEU LEU SER PHE 0.534351 0.78125
17 TYR GLY GLY PHE MET 0.533333 0.803279
18 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.531034 0.901639
19 SER ASP TYR GLN ARG LEU 0.52459 0.866667
20 ASP ALA GLU PHE ARG HIS ASP 0.52381 0.75
21 ALA GLN PHE SER ALA SER ALA SER ARG 0.52 0.71875
22 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.519685 0.796875
23 SER GLU ILE GLU PHE ALA ARG LEU 0.514706 0.75
24 LEU PRO PHE GLU ARG ALA THR VAL MET 0.512821 0.706667
25 LEU PRO PHE GLU ARG ALA THR ILE MET 0.506329 0.697368
26 ARG GLY TYR LEU TYR GLN GLY LEU 0.503759 0.9
27 SER SER ILE GLU PHE ALA ARG LEU 0.503597 0.738462
28 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.5 0.75
29 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.5 0.725806
30 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.496855 0.865672
31 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.496454 0.866667
32 PHE GLU ASP LEU ARG VAL SER SER PHE 0.496454 0.78125
33 PHE GLU ASP LEU ARG VAL LEU SER PHE 0.496454 0.78125
34 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.493671 0.753247
35 ILE GLY PRO GLY ARG ALA PHE TYR ALA 0.493421 0.736111
36 ALA ARG THR GLU LEU TYR ARG SER LEU 0.492754 0.8
37 GLY ASN PHE LEU GLN SER ARG 0.492537 0.727273
38 GLY GLY LYS LYS ARG TYR LYS LEU 0.492308 0.83871
39 GLY GLY ARG LYS LYS TYR LYS LEU 0.492308 0.83871
40 GLY GLY LYS LYS LYS TYR ARG LEU 0.492308 0.83871
41 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.490909 0.780822
42 VAL MET ALA PRO ARG THR LEU PHE LEU 0.490196 0.706667
43 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.489655 0.83871
44 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.489655 0.868852
45 ARG TYR GLY PHE VAL ALA ASN PHE 0.489362 0.84127
46 ALA VAL TYR ASN PHE ALA THR MET 0.488889 0.75
47 GLU ASN LEU TYR PHE GLN 0.488189 0.725806
48 VAL ALA PHE ARG SER 0.487805 0.766667
49 ACE PHE LYS PHE TA2 ALA LEU ARG NH2 0.482269 0.769231
50 MET ABA LEU ARG MET THR ALA VAL MET 0.481481 0.793651
51 ILE GLY PRO GLY ARG ALA PHE TYR THR 0.480769 0.726027
52 ILE GLY PRO GLY ARG ALA PHE TYR VAL 0.480769 0.75
53 THR PHE GLN ALA PSA LEU ARG GLU 0.48 0.784615
54 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.478571 0.734375
55 ARG ARG PHE AIB ALA MET LEU ALA 0.478571 0.822581
56 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.477419 0.776119
57 LEU TYR LEU VAL CYS GLY GLU ARG GLY 0.475862 0.868852
58 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.475524 0.825397
59 LEU GLU LYS ALA ARG GLY SER THR TYR 0.473684 0.776119
60 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.472973 0.815385
61 SER SER ARG LYS GLU TYR TYR ALA 0.472868 0.852459
62 MET CYS LEU ARG MET THR ALA VAL MET 0.471014 0.793651
63 GLU LEU LYS TPO GLU ARG TYR 0.468966 0.732394
64 ASP ALA GLU PHE ARG HIS ASP SER 0.468085 0.686567
65 ARG PRO MET THR TYR LYS GLY ALA LEU 0.466667 0.736842
66 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.466216 0.701493
67 SER GLU LEU GLU ILE LYS ARG TYR 0.464789 0.787879
68 TYR GLY GLY PHE LEU 0.463415 0.754098
69 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.463415 0.675676
70 LEU PRO PHE ASP ARG THR THR ILE MET 0.462025 0.688312
71 SER ARG TYR TRP ALA ILE ARG THR ARG 0.461538 0.746479
72 MET CYS LEU ARG NLE THR ALA VAL MET 0.460993 0.78125
73 ARG PRO MET THR PHE LYS GLY ALA LEU 0.460606 0.697368
74 ILE GLY PRO GLY ARG ALA PHE TYR THR ILE 0.460123 0.706667
75 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.459459 0.710145
76 PHE LEU GLU LYS 0.458333 0.683333
77 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.458333 0.707692
78 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.457516 0.662338
79 ARG ARG LEU LEU ARG GLY HIS ASN GLN TYR 0.456954 0.757143
80 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.456954 0.652778
81 ARG ARG LEU ILE PHE NH2 0.456693 0.75
82 ARG PRO GLY ASN PHE LEU GLN ASN ARG PRO 0.456522 0.714286
83 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.455172 0.653333
84 PTR LEU ARG VAL ALA 0.454545 0.772727
85 GLY ASN TYR SER PHE TYR ALA LEU 0.453846 0.681818
86 ACE PHE ALA TYR M3L SER NH2 0.453125 0.714286
87 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.452941 0.736842
88 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.452055 0.793651
89 GLU LEU ASP LYS TYR ALA SER 0.451852 0.71875
90 LEU ARG ASN GLN SER VAL PHE ASN PHE 0.450704 0.784615
91 ARG HIS LYS ALY LEU MET PHE LYS 0.450331 0.761194
92 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.450331 0.648649
93 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.450331 0.723077
94 ALA MET TYR LYS 0.45 0.830508
95 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.449275 0.730159
96 PHQ LEU VAL ARG TYR 0.448529 0.870968
97 ALA PHE ARG ILE PRO LEU THR ARG 0.447368 0.644737
98 CYS VAL PHE MET 0.445378 0.711864
99 VAL PRO LEU ARG PRO MET THR TYR 0.445161 0.746667
100 ARG GLY TYR VAL TYR GLN GLY LEU 0.443662 0.9
101 ASN ARG LEU MET LEU THR GLY 0.44186 0.78125
102 FME TYR PHE ILE ASN ILE LEU THR LEU 0.441379 0.753846
103 ASP ALA ASP GLU TYR LEU 0.440945 0.688525
104 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 0.440945 0.651515
105 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.440559 0.746032
106 GLY ALA ASP ILE PHE TYR LEU ASP GLY ALA 0.440298 0.721311
107 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.438272 0.685714
108 MET ALA ARG 0.4375 0.810345
109 GLY ASN CYS PHE SER LYS ARG ARG ALA ALA 0.43662 0.69697
110 TYR GLN PHE 0.434783 0.677966
111 ALA ARG THR MLY GLN THR ALA ARG TYR 0.433566 0.797101
112 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.433566 0.680556
113 ASP TYR ASN PRO TYR LEU LEU PHE LEU LYS 0.430464 0.631579
114 ASP GLU LEU GLU ILE LYS ALA TYR 0.429577 0.730159
115 ALA THR ILE GLY THR ALA MET TYR LYS 0.42953 0.753846
116 GLY LEU MET TRP LEU SER TYR PHE VAL 0.427632 0.728571
117 ALA ALA SER LEU TYR GLU LYS LYS ALA ALA 0.427536 0.707692
118 PHE LEU PRO HIS ALY TYR ASP VAL LYS LEU 0.426035 0.662162
119 HIS LEU TYR PHE SER SEP ASN 0.425676 0.602564
120 ACE CSO ARG ALA THR LYS MET LEU 0.425532 0.694444
121 ARG THR PHE SER PRO THR TYR GLY LEU 0.425 0.710526
122 LYS ALA ARG VAL LEU ALA GLU ALA MET SER 0.42446 0.813559
123 ASP PHE GLN GLU SER ALA ASP SER PHE LEU 0.42446 0.6875
124 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.423313 0.648649
125 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.423313 0.788732
126 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.421769 0.647059
127 ALA LYS PHE ARG HIS ASP 0.421429 0.676471
128 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.421053 0.652778
129 ACE ALA ARG THR GLU VAL TYR NH2 0.42029 0.822581
130 SER ARG ILE ARG ILE ARG GLY TYR VAL ARG 0.41958 0.776119
131 ARG ABA PHE ILE PHE ALA ASN ILE 0.41844 0.761905
132 THR ASN LEU TYR MET LEU 0.41791 0.71875
133 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.417722 0.767123
134 ALA ALA LEU THR ARG ALA 0.416 0.737705
135 LEU LEU TYR GLY PHE VAL ASN TYR VAL 0.415493 0.730159
136 PHE GLU ALA ASN GLY ASN LEU ILE 0.415493 0.630769
137 THR LYS CYS VAL PHE MET 0.414815 0.746032
138 ALA PTR ARG 0.414634 0.727273
139 TYR GLN SER LYS LEU 0.414062 0.71875
140 SER GLY ILE PHE LEU GLU THR SER 0.413534 0.630769
141 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.413333 0.657143
142 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.412903 0.657534
143 TYR HIS SEP VAL VAL ARG TYR ALA 0.412903 0.684211
144 LEU ALA ILE TYR SER 0.412698 0.704918
145 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.410853 0.745763
146 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.410714 0.675325
147 MET LEU TRP GLY TYR LEU GLN TYR VAL 0.410256 0.787879
148 ARG ABA VAL ILE PHE ALA ASN ILE 0.409722 0.746032
149 ARG ARG GLU VAL HIS THR TYR TYR 0.409091 0.757143
150 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.409091 0.625
151 ILE SER TYR GLY ASN ASP ALA LEU MET PRO 0.408537 0.641026
152 ALA TYR ARG 0.408333 0.827586
153 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.407643 0.623377
154 PHE ALA GLY LEU ARG GLN ALA VAL THR GLN 0.407407 0.730159
155 ARG GLY PHE ALA LEU M3L SER THR HIS GLY 0.407186 0.670886
156 BP4 CYS DAR TYR PEA 0.407143 0.806452
157 ARG ARG ALA ALA 0.40708 0.711864
158 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.40625 0.613333
159 DTY ILE ARG LEU LPD 0.405594 0.71831
160 GLU THR VAL ARG PHE GLN SER ASP 0.405405 0.761905
161 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.405405 0.661538
162 GLN TYR PHE MET TPO GLU PTR VAL ALA 0.404908 0.732394
163 ARG LEU TRP SER 0.404412 0.757576
164 LEU LEU TYR GLY PHE VAL ASN TYR ILE 0.40411 0.71875
165 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.403974 0.727273
166 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.403509 0.679487
167 ASP PHE GLU ASP TYR GLU PHE ASP 0.403101 0.693548
168 GLY LEU TYR ALA SER LYS LEU ALA 0.402985 0.692308
169 ARG ARG ALA THR LYS MET NH2 0.402985 0.75
170 THR ASN GLU PHE TYR ALA 0.401515 0.65625
171 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.401361 0.73913
172 ASP PHE GLU LYS GLU GLY TYR SER LEU 0.401316 0.716418
173 GLU ALA GLN THR ARG LEU 0.4 0.741935
174 MET LEU ILE TYR SER MET TRP GLY LYS 0.4 0.712329
175 SER LEU TYR LEU THR VAL ALA THR LEU 0.4 0.666667
Similar Ligands (3D)
Ligand no: 1; Ligand: PHE TYR ARG ALA LEU MET; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
Feedback