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Receptor
PDB id Resolution Class Description Source Keywords
1JQD 2.28 Å EC: 2.1.1.8 CRYSTAL STRUCTURE ANALYSIS OF HUMAN HISTAMINE METHYLTRANSFER (THR105 POLYMORPHIC VARIANT) COMPLEXED WITH ADOHCY AND HIST HOMO SAPIENS CLASSIC METHYLTRANSFERASE FOLD PROTEIN-SUBSTRATE-COFACTOR CTRANSFERASE
Ref.: TWO POLYMORPHIC FORMS OF HUMAN HISTAMINE METHYLTRAN STRUCTURAL, THERMAL, AND KINETIC COMPARISONS. STRUCTURE V. 9 837 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
HSM A:600;
B:601;
Valid;
Valid;
none;
none;
submit data
111.145 C5 H9 N3 c1c(n...
SAH A:400;
B:401;
Valid;
Valid;
none;
none;
Ki = 6.9 uM
384.411 C14 H20 N6 O5 S c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1JQD 2.28 Å EC: 2.1.1.8 CRYSTAL STRUCTURE ANALYSIS OF HUMAN HISTAMINE METHYLTRANSFER (THR105 POLYMORPHIC VARIANT) COMPLEXED WITH ADOHCY AND HIST HOMO SAPIENS CLASSIC METHYLTRANSFERASE FOLD PROTEIN-SUBSTRATE-COFACTOR CTRANSFERASE
Ref.: TWO POLYMORPHIC FORMS OF HUMAN HISTAMINE METHYLTRAN STRUCTURAL, THERMAL, AND KINETIC COMPARISONS. STRUCTURE V. 9 837 2001
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1JQD Ki = 6.9 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 2AOV Ki = 91 nM C2M C11 H10 Cl2 N4 Cc1c(c(nc(....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1JQD Ki = 6.9 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 2AOV Ki = 91 nM C2M C11 H10 Cl2 N4 Cc1c(c(nc(....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1JQD Ki = 6.9 uM SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 2AOV Ki = 91 nM C2M C11 H10 Cl2 N4 Cc1c(c(nc(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: HSM; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 HSM 1 1
2 AHN 0.428571 0.72973
Ligand no: 2; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1JQD; Ligand: HSM; Similar sites found with APoc: 5
This union binding pocket(no: 1) in the query (biounit: 1jqd.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 2XCG XCG 2.39726
2 1O5Q PYR 3.08219
3 5AMH EF2 5.6
4 2X32 OTP 6.70391
5 1KPG 16A 14.9826
Pocket No.: 2; Query (leader) PDB : 1JQD; Ligand: SAH; Similar sites found with APoc: 433
This union binding pocket(no: 2) in the query (biounit: 1jqd.bio1) has 31 residues
No: Leader PDB Ligand Sequence Similarity
1 5DM1 SAH None
2 5DM1 5D7 None
3 1BC5 SAH 1.11524
4 1NW5 SAM 1.36986
5 1WG8 SAM 1.40351
6 1P1C SAH 1.50754
7 3G2O SAM 1.71233
8 4LWP SAH 1.71233
9 3VSE SAH 1.71233
10 2YX1 SFG 1.71233
11 3X0D SAH 1.71233
12 6GKV SAH 1.71233
13 5MBX FAD 1.71233
14 5MBX SP5 1.71233
15 5JGL SAM 1.7301
16 4BLW SAH 1.7301
17 4BLW AMP 1.7301
18 6DUB SAH 1.8018
19 5EEH P9P 1.8617
20 5EEH SAH 1.8617
21 5ULP KB1 1.86567
22 4NEC SAH 1.89394
23 1G60 SAM 1.92308
24 5BSZ SAH 2
25 5GM1 SAH 2.05479
26 3NDJ JHZ 2.05479
27 3NDJ SAH 2.05479
28 1N2X SAM 2.05479
29 3ICS ADP 2.05479
30 5W7R SAH 2.05479
31 3ICT ADP 2.05479
32 4XFR CIT 2.05479
33 4RSL FAD 2.05479
34 1X87 NAD 2.05479
35 3VYW SAM 2.05479
36 5WZN A2G 2.05479
37 4M52 FAD 2.05479
38 4AP3 FAD 2.05479
39 4AP3 NAP 2.05479
40 4ZNO SUC 2.05479
41 5OC1 FAD 2.05479
42 5KOX FAD 2.05479
43 5KOX RFP 2.05479
44 2V3V MGD 2.05479
45 2Q28 ADP 2.05479
46 2D2I NAP 2.05479
47 1PDZ PGA 2.05479
48 1LSS NAD 2.14286
49 5LOG SAH 2.14592
50 1P77 ATR 2.20588
51 3HVJ 705 2.26244
52 2AG8 NAP 2.28137
53 4J4H NAI 2.3166
54 3MB5 SAM 2.35294
55 3FRH SAH 2.37154
56 1FP2 SAH 2.39726
57 6C8R EQV 2.39726
58 1RJW ETF 2.39726
59 2Q1S NAI 2.39726
60 3NJ4 NAD 2.39726
61 3NJ4 AFX 2.39726
62 1V6A TRE 2.39726
63 6C8R SAH 2.39726
64 3OND ADN 2.39726
65 3OND NAD 2.39726
66 3A8U PLP 2.39726
67 5ICE 2H4 2.39726
68 5ICE SAH 2.39726
69 3BMO AX4 2.43056
70 5JCJ 6JM 2.43056
71 3BMQ AX5 2.43056
72 3JQG AX6 2.43056
73 3T7S SAM 2.61194
74 1V59 NAD 2.73973
75 1SQF SAM 2.73973
76 5DWQ SFG 2.73973
77 5DXA SFG 2.73973
78 6ARJ BW4 2.73973
79 5DX8 SFG 2.73973
80 5DX1 SFG 2.73973
81 5DX0 SFG 2.73973
82 6ARJ SAH 2.73973
83 1SC6 NAD 2.73973
84 6ER9 NAP 2.73973
85 6ER9 FAD 2.73973
86 2A8X FAD 2.73973
87 1V59 FAD 2.73973
88 1RJD SAM 2.73973
89 4EIP FAD 2.73973
90 2IVD FAD 2.73973
91 2OBF F83 2.76817
92 2OBF SAH 2.76817
93 2PXX SAH 2.7907
94 3LCV SAM 2.84698
95 1WY7 SAH 2.89855
96 3LCC SAH 2.97872
97 3NZ1 3NY 3.06513
98 2OEM 1AE 3.08219
99 1Z3C SA8 3.08219
100 2ZWA SAH 3.08219
101 2ZIF SAM 3.08219
102 1LVL NAD 3.08219
103 4XQC 13D 3.08219
104 4XQC NAD 3.08219
105 2O07 SPD 3.08219
106 2IZ1 ATR 3.08219
107 5MB4 NAG 3.08219
108 5MB4 NDG 3.08219
109 3LKZ SFG 3.08219
110 2JK0 ASP 3.08219
111 1T36 U 3.08219
112 2O07 MTA 3.08219
113 2QA1 FAD 3.08219
114 2RAB NAD 3.08219
115 4YAC NAI 3.08219
116 1R18 SAH 3.0837
117 1M2K APR 3.21285
118 3A4T SFG 3.28467
119 4YMH SAH 3.33333
120 5CUQ NSC 3.37079
121 5FUB SAH 3.42466
122 4II2 ATP 3.42466
123 2P41 SAH 3.42466
124 4RVG SAM 3.42466
125 6C5B SAH 3.42466
126 4PIO AVI 3.42466
127 4PIO SAH 3.42466
128 4RVG TYD 3.42466
129 5LD5 NAD 3.42466
130 2DKH FAD 3.42466
131 3H2B SAH 3.44828
132 2BZG SAH 3.44828
133 3FZG SAM 3.5
134 1XTP SAI 3.54331
135 5X2N ALA 3.55556
136 2CFC KPC 3.6
137 2WA2 SAM 3.62319
138 2VDV SAM 3.65854
139 3WV8 ATP 3.66972
140 3DXY SAM 3.66972
141 2PX8 SAH 3.71747
142 4TTQ ATP 3.72093
143 3GDH SAH 3.73444
144 5E9W SAH 3.76712
145 1ZGA SAH 3.76712
146 4ONQ SFG 3.76712
147 5X7Q GLC GLC GLC GLC 3.76712
148 3OJO NAD 3.76712
149 5X7Q GLC GLC GLC 3.76712
150 1VJT NAD 3.76712
151 5FWA J7C 3.76712
152 1GPE FAD 3.76712
153 5M67 3D1 3.76712
154 5M67 NAD 3.76712
155 3O7W SAM 3.76712
156 5M67 ADE 3.76712
157 2Q0L NAP 3.76712
158 6C4N NAP 4.10959
159 4OPC PGT 4.10959
160 4OPC FDA 4.10959
161 3OFK SAH 4.16667
162 4RDN 6MD 4.19162
163 3RKR NAP 4.19847
164 1X14 NAD 4.2394
165 3EVG SAH 4.36364
166 3EGI ADP 4.36893
167 3FUU ADN 4.42804
168 1EJ0 SAM 4.44444
169 5KOK SAH 4.45205
170 3DMH SAM 4.45205
171 4AZW SAM 4.45205
172 3G89 SAM 4.45205
173 3DMH GMP 4.45205
174 3MAG SAH 4.45205
175 5JJR SAH 4.45205
176 3MCT SAH 4.45205
177 2EFJ SAH 4.45205
178 5KOK S9T 4.45205
179 5U19 827 4.45205
180 5U19 SAH 4.45205
181 3H8V ATP 4.45205
182 2YVJ NAI 4.45205
183 5KOK R9T 4.45205
184 2BRY FAD 4.45205
185 4TXI FAD 4.45205
186 1V8B NAD 4.45205
187 4RDH AMP 4.51389
188 4RDI ATP 4.51389
189 2A14 SAH 4.56274
190 3PFG SAM 4.56274
191 3PFG TLO 4.56274
192 4XUC SAM 4.58716
193 4XUC 43G 4.58716
194 3N8K D1X 4.65116
195 2AF6 BRU 4.65116
196 1L3I SAH 4.6875
197 4D79 ATP 4.71014
198 2FK8 SAM 4.79452
199 5THY SAH 4.79452
200 1FP1 SAH 4.79452
201 5THZ SAH 4.79452
202 1G55 SAH 4.79452
203 4A6D SAM 4.79452
204 5X62 SAH 4.79452
205 5F2K SAH 4.79452
206 5F2K OCA 4.79452
207 2HK9 ATR 4.79452
208 5DNK SAH 4.79452
209 6HKE MLT 4.79452
210 6HKE LMR 4.79452
211 5N5D SAM 4.86726
212 3GCZ SAM 4.96454
213 5FA8 SAM 4.96894
214 1I9G SAM 5
215 3BGD SAH 5
216 3BGD PM6 5
217 1Q0S SAH 5.01931
218 3TKY SAH 5.13699
219 1KYZ SAH 5.13699
220 2UYQ SAM 5.13699
221 5W7M SAH 5.13699
222 2VL1 GLY GLY 5.13699
223 3GFB NAD 5.13699
224 6F3N ADN 5.13699
225 6F3N NAD 5.13699
226 1YKJ FAD 5.13699
227 1YKJ PHB 5.13699
228 4E70 N7I 5.13699
229 4K5S PM0 5.13699
230 3ELW SAM 5.13699
231 3ELW GP3 5.13699
232 4K5S FAD 5.13699
233 3AYI HCI 5.13699
234 3AYI FAD 5.13699
235 3SSO SAH 5.13699
236 2DFV NAD 5.13699
237 1KYZ FER 5.13699
238 6F3M NAD 5.13699
239 3U31 NAD 5.17241
240 5M58 SAH 5.21739
241 2DPM SAM 5.28169
242 2EG5 SAH 5.47945
243 4KRG SAH 5.47945
244 2JJQ SAH 5.47945
245 1F3L SAH 5.47945
246 2Q3M MLA 5.47945
247 4YNU LGC 5.47945
248 4YNU FAD 5.47945
249 5Y8L NAD 5.47945
250 5YF1 8V0 5.52486
251 5YF1 SFG 5.52486
252 1NV8 MEQ 5.6338
253 1NV8 SAM 5.6338
254 5DLY 5D7 5.6391
255 5DLY SAH 5.6391
256 3A25 SAM 5.64784
257 5FA5 MTA 5.82192
258 4X60 3XV 5.82192
259 4X60 SFG 5.82192
260 4D04 NAP 5.82192
261 4D04 FAD 5.82192
262 1Y8Q ATP 5.82192
263 4GQB 0XU 5.82192
264 6BQ6 TER 5.82192
265 4JNA FAD 5.82192
266 1KYQ NAD 5.83942
267 2VT3 ATP 6.04651
268 4XZ3 COA 6.08696
269 3QV1 NAD 6.09756
270 1QZZ SAM 6.16438
271 3TKA SAM 6.16438
272 3UCL NAP 6.16438
273 3UCL CYH 6.16438
274 3UCL FAD 6.16438
275 3IHG FAD 6.16438
276 1XDS SAM 6.16438
277 5YB7 ORN 6.16438
278 5YB7 FAD 6.16438
279 3DUW SAH 6.27803
280 1A5V Y3 6.32911
281 4URS C2E 6.38298
282 5HJM MTA 6.50685
283 4C4A SAH 6.50685
284 5BJX NAD 6.50685
285 5BJX UDP 6.50685
286 2PT9 2MH 6.54206
287 2PT9 S4M 6.54206
288 5UFN SAH 6.72269
289 1JG3 ADN 6.80851
290 3FPZ AHZ 6.84932
291 3MQ2 SAH 6.88073
292 3CBG SAH 6.89655
293 2ZFU SAH 6.97674
294 5GWX SAM 7.04225
295 5GWX SAR 7.04225
296 3GU3 SAH 7.19178
297 4PNE SAH 7.19178
298 3VC1 SAH 7.19178
299 3VC1 GST 7.19178
300 1BW9 NAD 7.19178
301 1ELI PYC 7.19178
302 1JQ3 AAT 7.19178
303 4QTU SAM 7.21154
304 5ZZ6 ADP 7.21154
305 2I7C AAT 7.42049
306 6ECT SAM 7.53425
307 3TLJ SAH 7.53425
308 5JE8 NAD 7.53425
309 2JHP SAH 7.53425
310 4OBW SAM 7.7821
311 5XLX SAH 7.80142
312 5FTW SAH 7.8125
313 4M73 M72 7.87671
314 4M73 SAH 7.87671
315 4DMG SAM 7.87671
316 5TS5 FAD 7.87671
317 3P2E SAH 8
318 6F5Z SAH 8.19672
319 5W7K SAH 8.21918
320 4KIB SAH 8.21918
321 6B92 SAH 8.21918
322 4DCM SAM 8.21918
323 5E72 SAM 8.21918
324 1REO FAD 8.21918
325 1MAI I3P 8.39695
326 1I1N SAH 8.40708
327 4POO SAM 8.5
328 3JWH SAH 8.75576
329 3FPF TNA 8.90411
330 3FPF MTA 8.90411
331 2GAG NAD 9.24658
332 5MGZ SAH 9.32203
333 2NXE SAM 9.44882
334 6GFK SAH 9.56175
335 5T67 JHZ 9.58904
336 5T67 SAH 9.58904
337 2CDU ADP 9.58904
338 4Y30 49L 9.58904
339 4Y30 SAH 9.58904
340 4OM8 NAD 9.58904
341 3G5S FAD 9.58904
342 3BXO SAM 9.62343
343 5ZW3 SAH 9.77778
344 2HYQ MAN MAN 9.83607
345 2HYR BGC GLC 9.83607
346 2GUD MAN 9.83607
347 2GUC MAN 9.83607
348 2GUD BMA 9.83607
349 2NU5 NAG 9.83607
350 3LST SAH 9.93151
351 2HNK SAH 10.0418
352 5BW4 SAM 10.1124
353 5JE0 SAH 10.1215
354 5JE0 AZ8 10.1215
355 1QAN SAH 10.2459
356 2EJU SAH 10.274
357 1XPJ TLA 10.3175
358 1G8K MGD 10.5263
359 6AIN FAD 10.5263
360 5YJF 8WO 10.5634
361 5YJF SAH 10.5634
362 5AHO TLA 10.6164
363 3I53 SAH 10.8434
364 1DL5 SAH 10.9589
365 5TWB FAD 10.9589
366 5CX6 CDP 10.9589
367 3Q87 SAM 11.2
368 5E1M SAH 11.2033
369 5E1M PRO PRO LYS ARG ILE ALA 11.2033
370 4R6W PC 11.2403
371 4R6W SAH 11.2403
372 2PWY SAH 11.2403
373 1U2Z SAH 11.3014
374 1OBB NAD 11.3014
375 1HYH NAD 11.3014
376 3PT9 SAH 11.3014
377 1VE3 SAM 11.4537
378 1L1E SAH 11.4983
379 1ZQ9 SAM 11.5789
380 5YJI 8WO 11.6197
381 5YJI SAH 11.6197
382 5ERG SAM 11.6438
383 5MW4 5JU 11.6438
384 5LWY OLB 11.6438
385 1TPY SAH 11.8467
386 5KVA SAM 12.2302
387 4YUW 4JU 12.3288
388 6B3A SAM 12.3288
389 4YUW S4M 12.3288
390 5O2J 2PO 12.4542
391 3GWZ SAH 12.6712
392 3GXO SAH 12.6712
393 5MPT SAH 12.6712
394 5N6C NAD 12.6712
395 1IM8 SAI 12.7049
396 3L9W AMP 13.0137
397 3L9W GSH 13.0137
398 2XVM SAH 13.0653
399 4M37 SAH 13.3562
400 4M38 SAH 13.3562
401 1H82 FAD 13.3562
402 1H82 GZZ 13.3562
403 3QOX SAH 13.6986
404 6ECU SAH 14.0411
405 5TVF CGQ 14.1176
406 2XYQ SAH 14.7541
407 1KPG SAH 14.9826
408 3GRU AMP 15.0685
409 3ML1 MGD 15.0685
410 3A27 SAM 15.0735
411 6ECW SAH 15.411
412 4UCI SAM 15.411
413 5YRM BGC GLC 15.493
414 5YRJ BGC GLC 15.493
415 5YRL GLC GLC 15.493
416 5YRG BGC GLC 15.493
417 5WP5 SAH 15.7534
418 5WP4 SAH 15.7534
419 5E8J SAH 15.9091
420 4FZV SAM 16.0959
421 6D6Y SAH 16.4384
422 5OFW 9TW 16.5919
423 2HMT NAI 16.6667
424 4IWN GEK 17.0306
425 3S1S SAH 17.8082
426 3B1F NAD 17.931
427 4KRI SAH 18.1507
428 1UP7 NAD 18.1507
429 5N53 8NB 18.9744
430 3OU2 SAH 19.2661
431 6FDF SAH 20.8904
432 1KPH SAH 22.9965
433 5F8F SFG 29.1096
Pocket No.: 3; Query (leader) PDB : 1JQD; Ligand: HSM; Similar sites found with APoc: 317
This union binding pocket(no: 3) in the query (biounit: 1jqd.bio2) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 5DM1 SAH None
2 5DM1 5D7 None
3 5CLO NS8 None
4 1BC5 SAH 1.11524
5 1WG8 SAM 1.40351
6 1P1C SAH 1.50754
7 3G2O SAM 1.71233
8 6GKV SAH 1.71233
9 3X0D SAH 1.71233
10 4LWP SAH 1.71233
11 3VSE SAH 1.71233
12 2YX1 SFG 1.71233
13 4WOE 3S5 1.71233
14 5JGL SAM 1.7301
15 6DUB SAH 1.8018
16 5EEH P9P 1.8617
17 5EEH SAH 1.8617
18 4NEC SAH 1.89394
19 1G60 SAM 1.92308
20 5BSZ SAH 2
21 3NDJ JHZ 2.05479
22 3NDJ SAH 2.05479
23 5GM1 SAH 2.05479
24 5W7R SAH 2.05479
25 4M52 FAD 2.05479
26 1N2X SAM 2.05479
27 4RSL FAD 2.05479
28 5W7R 9Z7 2.05479
29 4L8F MTX 2.05479
30 2V3V MGD 2.05479
31 1X87 NAD 2.05479
32 4ZNO SUC 2.05479
33 3EVF GTA 2.16606
34 3EVF SAH 2.16606
35 3HVJ 705 2.26244
36 4J4H NAI 2.3166
37 4J4H 1J1 2.3166
38 3MB5 SAM 2.35294
39 3FRH SAH 2.37154
40 1FP2 SAH 2.39726
41 6C8R SAH 2.39726
42 5ICE 2H4 2.39726
43 2Q1S NAI 2.39726
44 6C8R EQV 2.39726
45 5ICE SAH 2.39726
46 1RJW ETF 2.39726
47 3NJ4 NAD 2.39726
48 3NJ4 AFX 2.39726
49 1FP2 HMO 2.39726
50 3BMO AX4 2.43056
51 3BMN AX3 2.43056
52 3T7S SAM 2.61194
53 1V59 NAD 2.73973
54 1RJD SAM 2.73973
55 6ARJ BW4 2.73973
56 5DXA SFG 2.73973
57 6ARJ SAH 2.73973
58 5DWQ SFG 2.73973
59 5DX1 SFG 2.73973
60 1SQF SAM 2.73973
61 5DX8 SFG 2.73973
62 5DX0 SFG 2.73973
63 2OBF SAH 2.76817
64 2OBF F83 2.76817
65 2PXX SAH 2.7907
66 3LCV SAM 2.84698
67 3LCC SAH 2.97872
68 2O07 SPD 3.08219
69 1Z3C SA8 3.08219
70 2O07 MTA 3.08219
71 2ZWA SAH 3.08219
72 5MB4 NAG 3.08219
73 2ZIF SAM 3.08219
74 4XQC NAD 3.08219
75 3LKZ SFG 3.08219
76 3GGO NAI 3.08219
77 3GGO ENO 3.08219
78 4YDD MD1 3.08219
79 4YDD MGD 3.08219
80 1R18 SAH 3.0837
81 5CUQ NSC 3.37079
82 4RVG TYD 3.42466
83 4RVG SAM 3.42466
84 6C5B SAH 3.42466
85 4PIO AVI 3.42466
86 4PIO SAH 3.42466
87 2P41 SAH 3.42466
88 4ZRN UPG 3.42466
89 4II2 ATP 3.42466
90 5LD5 NAD 3.42466
91 3H2B SAH 3.44828
92 2BZG SAH 3.44828
93 3FZG SAM 3.5
94 1XTP SAI 3.54331
95 2WA2 SAM 3.62319
96 2VDV SAM 3.65854
97 3DXY SAM 3.66972
98 3WV8 ATP 3.66972
99 2PX8 SAH 3.71747
100 4TTQ ATP 3.72093
101 3GDH SAH 3.73444
102 5E9W SAH 3.76712
103 1ZGA SAH 3.76712
104 4ONQ SFG 3.76712
105 3O7W SAM 3.76712
106 6C4N NAP 4.10959
107 4OPC PGT 4.10959
108 4OPC FDA 4.10959
109 3OFK SAH 4.16667
110 3RKR NAP 4.19847
111 3EVG SAH 4.36364
112 3EGI ADP 4.36893
113 3FUU ADN 4.42804
114 3G89 SAM 4.45205
115 2EFJ SAH 4.45205
116 5KOK SAH 4.45205
117 4AZW SAM 4.45205
118 3DMH GMP 4.45205
119 5KOK R9T 4.45205
120 3DMH SAM 4.45205
121 5JJR SAH 4.45205
122 5KOK S9T 4.45205
123 5U19 SAH 4.45205
124 5U19 827 4.45205
125 3MAG SAH 4.45205
126 4RDH AMP 4.51389
127 4RDI ATP 4.51389
128 3PFG TLO 4.56274
129 3PFG SAM 4.56274
130 2A14 SAH 4.56274
131 4XUC 43G 4.58716
132 4XUC SAM 4.58716
133 4D79 ATP 4.71014
134 2FK8 SAM 4.79452
135 1FP1 SAH 4.79452
136 5THY SAH 4.79452
137 4A6D SAM 4.79452
138 5THZ SAH 4.79452
139 5X62 SAH 4.79452
140 1G55 SAH 4.79452
141 5F2K OCA 4.79452
142 5F2K SAH 4.79452
143 3P9C SAH 4.79452
144 5DNK SAH 4.79452
145 3GCZ SAM 4.96454
146 5FA8 SAM 4.96894
147 1I9G SAM 5
148 3BGD PM6 5
149 3BGD SAH 5
150 5ME4 HP4 5.10949
151 3TKY SAH 5.13699
152 1KYZ SAH 5.13699
153 2UYQ SAM 5.13699
154 2VL1 GLY GLY 5.13699
155 5W7M SAH 5.13699
156 4E70 N7I 5.13699
157 3ELW SAM 5.13699
158 3ELW GP3 5.13699
159 3L4S 3PG 5.13699
160 3L4S NAD 5.13699
161 1YKJ PHB 5.13699
162 1YKJ FAD 5.13699
163 1KYZ FER 5.13699
164 6F3N NAD 5.13699
165 6F3N ADN 5.13699
166 5M58 SAH 5.21739
167 3PMA SCR 5.40541
168 2EG5 SAH 5.47945
169 4KRG SAH 5.47945
170 1F3L SAH 5.47945
171 2JJQ SAH 5.47945
172 2VPY MGD 5.47945
173 5YF1 SFG 5.52486
174 5YF1 8V0 5.52486
175 1NV8 SAM 5.6338
176 1NV8 MEQ 5.6338
177 5DLY SAH 5.6391
178 5DLY 5D7 5.6391
179 3A25 SAM 5.64784
180 5FA5 MTA 5.82192
181 4X60 3XV 5.82192
182 4X60 SFG 5.82192
183 6BQ6 TER 5.82192
184 4D04 FAD 5.82192
185 4D04 NAP 5.82192
186 4GQB 0XU 5.82192
187 1KYQ NAD 5.83942
188 2VT3 ATP 6.04651
189 3QV1 NAD 6.09756
190 1HDR NAD 6.14754
191 1XDS SAM 6.16438
192 1QZZ SAM 6.16438
193 1OW4 2AN 6.20155
194 5BJX NAD 6.50685
195 4C4A SAH 6.50685
196 5HJM MTA 6.50685
197 5BJX UDP 6.50685
198 2PT9 2MH 6.54206
199 5UFN SAH 6.72269
200 1JG3 ADN 6.80851
201 3MQ2 SAH 6.88073
202 2ZFU SAH 6.97674
203 5GWX SAM 7.04225
204 5GWX SAR 7.04225
205 3GU3 SAH 7.19178
206 4PNE SAH 7.19178
207 1JQ3 AAT 7.19178
208 3VC1 SAH 7.19178
209 3VC1 GST 7.19178
210 1ELI PYC 7.19178
211 4QTU SAM 7.21154
212 2I7C AAT 7.42049
213 2JHP SAH 7.53425
214 6ECT SAM 7.53425
215 5MLR GRQ 7.53425
216 5MLR NAP 7.53425
217 3TLJ SAH 7.53425
218 4OBW SAM 7.7821
219 5XLX SAH 7.80142
220 5FTW SAH 7.8125
221 4M73 SAH 7.87671
222 4M73 M72 7.87671
223 1YXM ADE 7.87671
224 4DMG SAM 7.87671
225 3WMX NAD 7.87671
226 3P2E SAH 8
227 6F5Z SAH 8.19672
228 5W7K SAH 8.21918
229 4KIB SAH 8.21918
230 5E72 SAM 8.21918
231 6B92 SAH 8.21918
232 5DF1 58X 8.21918
233 5DF1 NAP 8.21918
234 4POO SAM 8.5
235 3JWH SAH 8.75576
236 3FPF TNA 8.90411
237 3FPF MTA 8.90411
238 6CZ7 MGD 8.90411
239 2GAG FOA 9.24658
240 2GAG FAD 9.24658
241 5MGZ SAH 9.32203
242 2NXE SAM 9.44882
243 6GFK SAH 9.56175
244 5G6U TRP 9.57854
245 5T67 JHZ 9.58904
246 5T67 SAH 9.58904
247 2CDU ADP 9.58904
248 4Y30 SAH 9.58904
249 4Y30 49L 9.58904
250 3BXO SAM 9.62343
251 5ZW3 SAH 9.77778
252 2HYQ MAN MAN 9.83607
253 2GUD BMA 9.83607
254 2NU5 NAG 9.83607
255 2GUC MAN 9.83607
256 2GUD MAN 9.83607
257 2HYR BGC GLC 9.83607
258 2NUO BGC 9.83607
259 3LST SAH 9.93151
260 5BW4 SAM 10.1124
261 5JE0 SAH 10.1215
262 5JE0 AZ8 10.1215
263 1QAN SAH 10.2459
264 2EJU SAH 10.274
265 1G8K MGD 10.5263
266 5YJF 8WO 10.5634
267 5YJF SAH 10.5634
268 3I53 SAH 10.8434
269 1DL5 SAH 10.9589
270 5E1M PRO PRO LYS ARG ILE ALA 11.2033
271 5E1M SAH 11.2033
272 4R6W PC 11.2403
273 2PWY SAH 11.2403
274 4R6W SAH 11.2403
275 3PT9 SAH 11.3014
276 1VE3 SAM 11.4537
277 1L1E SAH 11.4983
278 1ZQ9 SAM 11.5789
279 5YJI 8WO 11.6197
280 5YJI SAH 11.6197
281 5MW4 5JU 11.6438
282 1TPY SAH 11.8467
283 4YUW S4M 12.3288
284 4YUW 4JU 12.3288
285 6B3A SAM 12.3288
286 1JNR FAD 12.6667
287 3GWZ SAH 12.6712
288 3GXO SAH 12.6712
289 5MPT SAH 12.6712
290 1IM8 SAI 12.7049
291 3L9W AMP 13.0137
292 2XVM SAH 13.0653
293 4CVN ADP 13.1387
294 4M38 SAH 13.3562
295 4M37 SAH 13.3562
296 3QOX SAH 13.6986
297 6ECU SAH 14.0411
298 1KPG SAH 14.9826
299 3GRU AMP 15.0685
300 3ML1 MGD 15.0685
301 3A27 SAM 15.0735
302 6ECW SAH 15.411
303 5YRL GLC GLC 15.493
304 5YRM BGC GLC 15.493
305 5WP5 SAH 15.7534
306 5WP4 SAH 15.7534
307 5E8J SAH 15.9091
308 6D6Y SAH 16.4384
309 5OFW 9TW 16.5919
310 4IWN GEK 17.0306
311 4F4S EFO 17.1053
312 4KRI SAH 18.1507
313 5N53 8NB 18.9744
314 1KPH SAH 22.9965
315 5F8F SFG 29.1096
316 5ZCO CHD 29.7872
317 5W97 CHD 29.7872
Pocket No.: 4; Query (leader) PDB : 1JQD; Ligand: SAH; Similar sites found with APoc: 83
This union binding pocket(no: 4) in the query (biounit: 1jqd.bio2) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 5CLO NS8 None
2 1XCL SAH 1.2766
3 3ETG GTP 1.36986
4 3NYC IAR 1.36986
5 3NYC FAD 1.36986
6 1UWK URO 1.71233
7 1UWK NAD 1.71233
8 4TQK NAG 2.05479
9 4ZUL UN1 2.05479
10 1CT9 AMP 2.05479
11 5XNC MTA 2.05479
12 5U8U FAD 2.05479
13 4L8F MTX 2.05479
14 4J4H 1J1 2.3166
15 3ORQ ADP 2.39726
16 1Q9I FAD 2.39726
17 1Q9I TEO 2.39726
18 1FP2 HMO 2.39726
19 3BMN AX3 2.43056
20 2IV2 MGD 2.73973
21 3M89 GSP 2.73973
22 2W47 UNF 2.77778
23 1UKG MMA 2.77778
24 2PHT MAN MAN MAN 2.77778
25 3M6W SAM 3.08219
26 2RAB FAD 3.08219
27 4YDD MGD 3.08219
28 4YDD MD1 3.08219
29 2REG CHT 3.08219
30 4UP4 NDG 3.42466
31 4UP4 GAL NAG 3.42466
32 3T3Z 9PL 3.42466
33 4ZVV NAD 3.76712
34 4ZVV GN0 3.76712
35 5ZDN CDP 3.79147
36 2OG2 MLI 4.10959
37 4BJZ P3A 4.10959
38 4BJZ FAD 4.10959
39 3QJ4 FAD 4.10959
40 1NBU PH2 4.20168
41 2P3V SRT 4.29688
42 3X0V FAD 4.45205
43 5BVA FAD 4.45205
44 2IF8 ADP 4.6832
45 3P9C SAH 4.79452
46 1D4D FAD 4.79452
47 5GSN FAD 4.79452
48 5GSN NAP 4.79452
49 5GSN MMZ 4.79452
50 5ME4 HP4 5.10949
51 3L4S 3PG 5.13699
52 3L4S NAD 5.13699
53 3PMA SCR 5.40541
54 4D7E FAD 5.47945
55 1K3T BRZ 5.47945
56 2VPY MGD 5.47945
57 3UOY NAP 5.82192
58 3UOY FAD 5.82192
59 4V3C C 5.82192
60 1CER NAD 6.16438
61 1GTE FAD 6.84932
62 1MO9 FAD 6.84932
63 1MO9 KPC 6.84932
64 3E1T FAD 7.19178
65 2XVE FAD 7.53425
66 1QO8 FAD 7.87671
67 1YXM ADE 7.87671
68 4TM3 FAD 7.87671
69 2IID PHE 8.21918
70 2IID FAD 8.21918
71 6CZ7 MGD 8.90411
72 2NUO BGC 9.83607
73 3RNM FAD 11.3014
74 2F5Z FAD 11.6438
75 5J5Z FAD 11.9863
76 1SQL GUN 12.3288
77 3K6V CIT 12.4294
78 4CVN ADP 13.1387
79 1MUU NAD 13.6986
80 1MV8 NAD 14.0411
81 1KPG 16A 14.9826
82 5WGR FAD 15.7534
83 5Z84 CHD 29.7872
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