Receptor
PDB id Resolution Class Description Source Keywords
1KY7 2.15 Å NON-ENZYME: OTHER THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER PHE PHE GLU ASP ASN PHE VAL PRO GLU P:322;
 Valid;
 none;
 submit data
1084.17 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: SER PHE PHE GLU ASP ASN PHE VAL PRO GLU; Similar ligands found: 118
No: Ligand ECFP6 Tc MDL keys Tc
1 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 1 1
2 PHE GLU ASP ASN PHE VAL PRO 0.689076 0.952381
3 ILE THR ASP GLN VAL PRO PHE SER VAL 0.531034 0.893939
4 ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG 0.523077 0.72
5 SER SER LEU GLU ASN PHE ALA ALA TYR VAL 0.517986 0.731343
6 SER ASP PTR MET ASN MET THR PRO 0.517483 0.769231
7 ILE MET ASP GLN VAL PRO PHE SER VAL 0.516779 0.855072
8 ASP PHE GLU ASP TYR GLU PHE ASP 0.516667 0.617647
9 SER ILE ILE ASN PHE GLU LYS LEU 0.514925 0.753846
10 GLY ALA PHE THR PHE ASN GLU ASP PHE 0.512 0.6875
11 ALA VAL ALA PHE TYR ILE PRO ASP GLN ALA 0.503759 0.794118
12 VAL ASN ASP ILE PHE GLU ALA ILE 0.496241 0.646154
13 SER PRO ILE VAL PRO SER PHE ASP MET 0.493243 0.857143
14 SER HIS PHE ASN GLU TYR GLU 0.492857 0.73913
15 GLU ASP GLU ASP PHE GLU ILE LEU SER LEU 0.489209 0.723077
16 ASP PHE GLU GLU ILE PRO GLU GLU TYS 0.486486 0.666667
17 ASP PHE GLN GLU SER ALA ASP SER PHE LEU 0.485075 0.765625
18 ALA ILE ALA TYR PHE ILE PRO ASP GLN ALA 0.485075 0.779412
19 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.484076 0.810811
20 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.481481 0.826667
21 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.477707 0.884058
22 ASP PHE GLU GLU ILE PRO GLY GLU PTR 0.477707 0.75
23 ALA THR PRO PHE GLN GLU 0.470588 0.84375
24 GLU GLU ASN LEU LEU ASP PHE VAL ARG PHE 0.468966 0.685714
25 ACE GLY ASN CYS PHE SER LYS PRO ARG 0.468531 0.863636
26 THR ASN GLU PHE TYR ALA 0.464567 0.681818
27 GLU ILE ILE ASN PHE GLU LYS LEU 0.463768 0.681818
28 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.463576 0.893939
29 ASP PHE GLU GLU ILE PRO GLY GLU TYR LEU 0.462025 0.84058
30 ASP GLU PTR GLU ASN VAL ASP 0.461538 0.60274
31 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.461538 0.953846
32 GLU PHE SER PRO 0.459016 0.857143
33 ASP ASP LEU ASP VAL PRO SER PHE LEU GLN 0.458904 0.9375
34 ILE ASN PHE ASP PHE ASN THR ILE 0.456 0.666667
35 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.455128 0.69863
36 GLU VAL PTR GLU SER PRO 0.453237 0.808219
37 SER THR SEP PRO THR PHE ASN LYS 0.452229 0.805556
38 SER PTR VAL ASN VAL GLN ASN 0.451128 0.657534
39 ASP ILE ASN TYR TYR THR SER GLU PRO 0.449664 0.911765
40 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.448718 0.826087
41 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.448052 0.80303
42 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.446667 0.863636
43 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.445255 0.723077
44 ASP PHE ALA ASN THR PHE LEU PRO 0.444444 0.938462
45 TRP GLU TYR ILE PRO ASN VAL 0.44375 0.830986
46 ALA GLU THR PHE TYR VAL ASP GLY 0.443609 0.681818
47 LEU GLU PHE GLN GLY 0.443548 0.65625
48 ASP ALA ASP GLU GLU ASP PHE 0.441667 0.634921
49 LEU PRO SER PHE GLU THR ALA LEU 0.439189 0.907692
50 SER ILE ILE GLN PHE GLU HIS LEU 0.4375 0.764706
51 ASP ILE ASN TYR TYR ALA SER GLU PRO 0.437086 0.911765
52 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.435374 0.723077
53 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.434783 0.895522
54 ASP PHE GLU GLU ILE PRO GLY GLU TYS LEU 0.434783 0.690476
55 SER LEU PHE ASN THR VAL ALA THR LEU 0.434783 0.676923
56 MET PHE SER ILE ASP ASN ILE LEU ALA 0.434483 0.681159
57 PHE ASN PHE PRO GLN ILE THR 0.434483 0.893939
58 ARG GLU ARG SER PRO THR ARG 0.429688 0.757143
59 VAL GLN GLN GLU SER SER PHE VAL MET 0.42963 0.676471
60 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.429577 0.865672
61 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.42953 0.776119
62 LYS PRO PHE PTR VAL ASN VAL NH2 0.428571 0.797297
63 THR PRO TYR ASP ILE ASN GLN MET LEU 0.427673 0.819444
64 ALA PRO SER PTR VAL ASN VAL GLN ASN 0.427632 0.824324
65 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.427632 0.611111
66 LEU ARG ASN GLN SER VAL PHE ASN PHE 0.427586 0.728571
67 ACE GLU ASN LEU TYR PHE GLN SER GLY THR 0.427536 0.661765
68 SER PHE ALA ASN GLY 0.42623 0.698413
69 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.423841 0.938462
70 SER GLN TYR TYR TYR ASN SER LEU 0.423077 0.731343
71 ARG PRO GLY ASN PHE PHE GLN ASN ARG PRO 0.421875 0.6875
72 SER LEU PHE ASN THR VAL ALA THR LEU TYR 0.421769 0.686567
73 THR LYS ASN TYR LYS GLN PHE SER VAL 0.421429 0.787879
74 GLU GLN TYR LYS PHE TYR SER VAL 0.421429 0.746269
75 SER GLY ILE PHE LEU GLU THR SER 0.421053 0.681818
76 ASP PHE SER ILE 0.420168 0.646154
77 LEU ASN PHE PRO ILE SER PRO 0.41844 0.924242
78 GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA 0.41844 0.686567
79 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.418301 0.835821
80 GLU ASN LEU TYR PHE GLN 0.41791 0.671642
81 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.417808 0.716418
82 ACE VAL PHE PHE ALA GLU ASP NH2 0.417323 0.634921
83 VAL VAL SER HIS PHE ASN ASP 0.417266 0.772727
84 SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.417219 0.724638
85 ASP ILE ASN TYS TYS THR SER GLU PRO 0.417219 0.746988
86 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.416667 0.823529
87 GLU THR PHE TYR VAL ASP GLY 0.416058 0.742424
88 TYR ASP LEU SEP LEU PRO PHE PRO 0.415094 0.8
89 VAL SER PHE ASN FRD PRO GLN ILE THR ALA 0.415094 0.910448
90 SER LEU ARG PHE LEU TYR GLU GLY 0.413793 0.684932
91 PHE GLU ASP LEU ARG VAL SER SER PHE 0.413333 0.7
92 PHE GLU ASP LEU ARG VAL LEU SER PHE 0.413333 0.7
93 GLU THR VAL ARG PHE GLN SER ASP 0.412162 0.657143
94 GLU VAL ASN 1OL ALA GLU PHE 0.410959 0.661538
95 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.410959 0.731343
96 SER LEU LYS ILE ASP ASN GLU ASP 0.410072 0.723077
97 LEU PRO PHE ASP LYS SER THR ILE MET 0.409639 0.830986
98 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.408451 0.742424
99 SER LEU PHE ASN THR ILE ALA VAL LEU 0.408163 0.666667
100 SER GLU ILE GLU PHE ALA ARG LEU 0.408163 0.647887
101 LEU PRO PHE GLU LYS SER THR VAL MET 0.407407 0.842857
102 SER ILE ILE GLY PHE GLU LYS LEU 0.406897 0.738462
103 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.40678 0.84058
104 PHE SER HIS PRO GLN ASN THR 0.406452 0.895522
105 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.406061 0.819444
106 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.406061 0.84058
107 PHE ASN ARG PRO VAL 0.405594 0.811594
108 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.405405 0.671642
109 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.404255 0.69697
110 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.403974 0.73913
111 PHE GLU ASP LEU ARG LEU LEU SER PHE 0.402778 0.7
112 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.401575 0.646154
113 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.401316 0.910448
114 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.401316 0.648649
115 LEU PRO PHE ASP LYS THR THR ILE MET 0.401235 0.816901
116 SER SER ILE GLU PHE ALA ARG LEU 0.4 0.661972
117 TRP ASN TRP PHE ASP ILE THR ASN LYS 0.4 0.695652
118 ASP TYR ASN PRO TYR LEU LEU PHE LEU LYS 0.4 0.897059
Similar Ligands (3D)
Ligand no: 1; Ligand: SER PHE PHE GLU ASP ASN PHE VAL PRO GLU; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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