Receptor
PDB id Resolution Class Description Source Keywords
1KYD 2 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLY SER ASP PRO TRP LYS P:341;
Valid;
none;
submit data
631.687 n/a O=C([...
SO4 A:200;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1KYU 1.8 Å NON-ENZYME: OTHER AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE MUS MUSCULUS PROTEIN-PEPTIDE COMPLEX ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: ACCESSORY PROTEIN RECRUITMENT MOTIFS IN CLATHRIN-MEDIATED ENDOCYTOSIS. STRUCTURE V. 10 797 2002
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 1KYU - GLY SER ASP PRO PHE LYS n/a n/a
2 1KYF - GLY SER ASP PRO PHE LYS n/a n/a
3 1KY6 - PHE SER ASP PRO TRP GLY GLY n/a n/a
4 1KYD - GLY SER ASP PRO TRP LYS n/a n/a
5 1KY7 - SER PHE PHE GLU ASP ASN PHE VAL PRO GLU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLY SER ASP PRO TRP LYS; Similar ligands found: 106
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY SER ASP PRO TRP LYS 1 1
2 GLY SER ASP PRO PHE LYS 0.723214 0.933333
3 PHE SER ASP PRO TRP GLY GLY 0.619403 0.983607
4 SER TRP PHE PRO 0.591667 0.95082
5 SER ASN TRP SER HIS PRO GLN PHE GLU LYS 0.576159 0.921875
6 TRP PRO TRP 0.566372 0.836066
7 THR LEU PRO TRP ASP LEU TRP THR THR 0.565217 0.878788
8 LYS TRP LYS 0.560748 0.75
9 MET TYR TRP TYR PRO TYR 0.555556 0.757143
10 SER PRO LEU ASP SER LEU TRP TRP ILE 0.553191 0.909091
11 ALA VAL PRO TRP 0.541667 0.809524
12 ASN ASP TRP LEU LEU PRO SER TYR 0.54 0.857143
13 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.537931 0.875
14 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.531034 0.782609
15 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.528662 0.791667
16 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.528302 0.848485
17 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.526667 0.888889
18 LYS PRO HIS SER ASP 0.507692 0.919355
19 MET TRP ARG PRO TRP 0.507042 0.689189
20 PRO GLN PRO VAL ASP SER TRP VAL 0.506579 0.9375
21 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.50365 0.84375
22 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.503067 0.8
23 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.5 0.722222
24 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.5 0.753425
25 MET VAL TRP GLY PRO ASP PRO LEU TYR VAL 0.49697 0.791667
26 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.496504 0.805556
27 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.49359 0.797297
28 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.490909 0.8
29 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.490798 0.818182
30 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.488372 0.753623
31 GLU PRO GLN ALA PRO TRP MET GLU 0.486667 0.782609
32 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.483221 0.878788
33 MDL 0.48062 0.7
34 LYS TRP 0.477064 0.7
35 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.475309 0.857143
36 ARG PHE PRO LEU THR PHE GLY TRP 0.475309 0.794521
37 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.474026 0.830769
38 ASP GLU ASP LYS TRP ASP ASP PHE 0.472868 0.770492
39 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.471698 0.882353
40 ALA PRO ALA TRP LEU PHE GLU ALA 0.464052 0.80303
41 GLU LEU ASP LYS TRP ALA SER 0.463768 0.796875
42 ACE TRP ARG VAL PRO 0.463768 0.746479
43 ALA LEU ASP LYS TRP ALA SER 0.462687 0.796875
44 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.461988 0.773333
45 ALA LEU ASP LYS TRP ASP 0.460938 0.734375
46 ASP TRP ASN 0.46087 0.693548
47 GLU ASP ASN ASP TRP ASN 0.46087 0.693548
48 GLU ALA ASP LYS TRP GLN SER 0.460432 0.83871
49 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.460123 0.791667
50 GLU LYS PRO SER SER SER 0.459016 0.9
51 ARG TYR PRO LEU THR PHE GLY TRP 0.458333 0.773333
52 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.457831 0.771429
53 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.456647 0.797297
54 MET HIS PRO ALA GLN THR SER GLN TRP 0.454545 0.84507
55 GLU ASN ASP LYS TRP ALA SER 0.453237 0.825397
56 TRP GLU TYR ILE PRO ASN VAL 0.452229 0.788732
57 ILE SER PRO ARG THR LEU ASP ALA TRP 0.450292 0.821918
58 GLU GLN ASP LYS TRP ALA SER 0.45 0.83871
59 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.447674 0.779221
60 GLU LEU ASP ORN TRP ALA SER 0.446809 0.78125
61 GLU LEU GLU LYS TRP ALA SER 0.445255 0.78125
62 PCA LYS TRP 0.444444 0.770492
63 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.443038 0.830769
64 SER LEU ILE PRO TPO PRO ASP LYS 0.442177 0.753425
65 LYS PRO LYS 0.441441 0.733333
66 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.441341 0.776316
67 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.441176 0.904762
68 ARG LEU TRP SER 0.438462 0.661972
69 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.435374 0.8125
70 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.435028 0.769231
71 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.429487 0.850746
72 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.427778 0.769231
73 PHE ALA PRO GLY ASN TYR PRO ALA TRP 0.427711 0.84058
74 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.426667 0.848485
75 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.424658 0.705882
76 LYS ARG ARG ARG HIS PRO SER GLY 0.424658 0.823529
77 LEU PRO PHE ASP LYS THR THR ILE MET 0.424051 0.771429
78 LEU PRO PHE ASP LYS SER THR ILE MET 0.423313 0.8
79 GLU LEU ASP HIS TRP ALA SER 0.421769 0.742424
80 SER ARG ASP HIS SER ARG THR PRO MET 0.419753 0.75
81 GLU LEU ASP LYS TRP ALA ASN 0.41958 0.727273
82 GLU LEU ASP LYS TRP ALA GLY 0.41844 0.723077
83 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.416667 0.643836
84 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.415301 0.763158
85 SER ASP ILE LEU PHE PRO ALA ASP SER 0.414966 0.846154
86 TRP GLU GLU LEU 0.414634 0.65625
87 LYS ARG ARG ARG HIS PRO SER 0.413793 0.779412
88 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.413174 0.75
89 LEU PRO PHE GLU LYS SER THR VAL MET 0.4125 0.811594
90 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.410072 0.796875
91 PHE PRO THR LYS ASP VAL ALA LEU 0.407895 0.830769
92 LEU SER SER PRO VAL THR LYS SER PHE 0.406667 0.846154
93 ASP SER LYS ASP VAL LYS GLU TRP TYR VAL ZN 0.406452 0.757143
94 SER SER CYS SER SER CYS PRO LEU SER LYS 0.406452 0.760563
95 LYS THR PHE PRO PRO THR GLU PRO LYS 0.406452 0.873016
96 ALA LEU ASP LYS TRP GLN ASN 0.406015 0.71875
97 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.405882 0.76
98 GLU LEU ASP HOX TRP ALA SER 0.405405 0.705882
99 ASP ASN TRP GLN ASN GLY THR SER 0.405405 0.796875
100 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.40411 0.892308
101 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.403974 0.838235
102 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.401316 0.708333
103 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.401274 0.769231
104 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.401099 0.753425
105 SER SER GLY LYS VAL PRO LEU 0.4 0.828125
106 VAL LYS PRO GLY 0.4 0.746032
Similar Binding Sites (Proteins are less than 50% similar to leader)
Feedback