Receptor
PDB id Resolution Class Description Source Keywords
1LCP 1.65 Å EC: 3.4.11.1 BOVINE LENS LEUCINE AMINOPEPTIDASE COMPLEXED WITH L-LEUCINE ACID BOS TAURUS HYDROLASE (ALPHA-AMINOACYLPEPTIDE)
Ref.: TRANSITION STATE ANALOGUE L-LEUCINEPHOSPHONIC ACID BOVINE LENS LEUCINE AMINOPEPTIDASE: X-RAY STRUCTURE A RESOLUTION IN A NEW CRYSTAL FORM. BIOCHEMISTRY V. 34 9200 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MRD A:501;
A:502;
A:503;
B:501;
B:502;
B:503;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
118.174 C6 H14 O2 C[C@H...
PLU A:500;
B:500;
Valid;
Valid;
none;
none;
Ki = 0.23 uM
167.143 C5 H14 N O3 P CC(C)...
ZN A:488;
A:489;
A:490;
B:488;
B:489;
B:490;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LAN 1.9 Å EC: 3.4.11.1 LEUCINE AMINOPEPTIDASE COMPLEX WITH L-LEUCINAL BOS TAURUS AMINOPEPTIDASE EXOPEPTIDASE METALLOPEPTIDASE HYDROLASE (AAMINOACYLPEPTIDE)
Ref.: TWO-METAL ION MECHANISM OF BOVINE LENS LEUCINE AMINOPEPTIDASE: ACTIVE SITE SOLVENT STRUCTURE AND B MODE OF L-LEUCINAL, A GEM-DIOLATE TRANSITION STATE BY X-RAY CRYSTALLOGRAPHY. BIOCHEMISTRY V. 34 14792 1995
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PLU; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 PLU 1 1
2 NLP 0.419355 0.805556
3 MPH 0.40625 0.74359
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: 1
This union binding pocket(no: 2) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5NTD BES 31.405
Pocket No.: 3; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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