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Receptor
PDB id Resolution Class Description Source Keywords
1LCP 1.65 Å EC: 3.4.11.1 BOVINE LENS LEUCINE AMINOPEPTIDASE COMPLEXED WITH L-LEUCINE ACID BOS TAURUS HYDROLASE (ALPHA-AMINOACYLPEPTIDE)
Ref.: TRANSITION STATE ANALOGUE L-LEUCINEPHOSPHONIC ACID BOVINE LENS LEUCINE AMINOPEPTIDASE: X-RAY STRUCTURE A RESOLUTION IN A NEW CRYSTAL FORM. BIOCHEMISTRY V. 34 9200 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MRD A:501;
A:502;
A:503;
B:501;
B:502;
B:503;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
118.174 C6 H14 O2 C[C@H...
PLU A:500;
B:500;
Valid;
Valid;
none;
none;
Ki = 0.23 uM
167.143 C5 H14 N O3 P CC(C)...
ZN A:488;
A:489;
A:490;
B:488;
B:489;
B:490;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LAN 1.9 Å EC: 3.4.11.1 LEUCINE AMINOPEPTIDASE COMPLEX WITH L-LEUCINAL BOS TAURUS AMINOPEPTIDASE EXOPEPTIDASE METALLOPEPTIDASE HYDROLASE (AAMINOACYLPEPTIDE)
Ref.: TWO-METAL ION MECHANISM OF BOVINE LENS LEUCINE AMINOPEPTIDASE: ACTIVE SITE SOLVENT STRUCTURE AND B MODE OF L-LEUCINAL, A GEM-DIOLATE TRANSITION STATE BY X-RAY CRYSTALLOGRAPHY. BIOCHEMISTRY V. 34 14792 1995
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PLU; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 PLU 1 1
2 NLP 0.419355 0.805556
3 MPH 0.40625 0.74359
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: 34
This union binding pocket(no: 2) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5BUK FAD 0.888889
2 2VHW NAI 1.59151
3 2J4K U5P 2.21239
4 2BLE 5GP 2.45232
5 1Q3Q ANP 2.47934
6 4O08 PO6 2.49221
7 2P3V SRT 2.73438
8 5NQR 958 2.73973
9 2E5V FAD 2.75424
10 3HQP OXL 2.89256
11 6AMI TRP 3.0303
12 5TIV A3P 3.55731
13 4R8L ASP 3.63636
14 5HGZ ACO 3.7037
15 4AF0 IMP 3.71901
16 2PT9 2MH 3.73832
17 1WOG 16D 3.93443
18 4FK7 P34 4.36681
19 2J0W ASP 4.45434
20 2ED4 NAD 4.69799
21 5WS9 OXL 4.84211
22 5X9D 80F 4.93421
23 3LLZ GAL NGA 5.26316
24 2BO4 FLC 5.79345
25 4M0R 644 5.80475
26 1QSM ACO 5.92105
27 1JXN MFU 6.19835
28 4US3 TRP 6.81319
29 1YRO GDU 7.31707
30 4PPF FLC 7.42857
31 2HIM ASP 8.10056
32 6FFK D7Z 11.1111
33 5NTD BES 31.405
34 5NTH BB2 39.2193
Pocket No.: 3; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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