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Receptor
PDB id Resolution Class Description Source Keywords
1LES 1.9 Å NON-ENZYME: BINDING LENTIL LECTIN COMPLEXED WITH SUCROSE LENS CULINARIS PROTEIN-SUGAR INTERACTIONS LECTIN
Ref.: NMR, MOLECULAR MODELING, AND CRYSTALLOGRAPHIC STUDI LENTIL LECTIN-SUCROSE INTERACTION. J.BIOL.CHEM. V. 270 25619 1995
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:203;
C:201;
Part of Protein;
Part of Protein;
none;
none;
submit data
40.078 Ca [Ca+2...
GLC FRU A:205;
C:207;
Valid;
Valid;
none;
none;
submit data
342.297 n/a O(C1C...
MN A:204;
C:202;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LES 1.9 Å NON-ENZYME: BINDING LENTIL LECTIN COMPLEXED WITH SUCROSE LENS CULINARIS PROTEIN-SUGAR INTERACTIONS LECTIN
Ref.: NMR, MOLECULAR MODELING, AND CRYSTALLOGRAPHIC STUDI LENTIL LECTIN-SUCROSE INTERACTION. J.BIOL.CHEM. V. 270 25619 1995
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 1LES - GLC FRU n/a n/a
70% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 1LES - GLC FRU n/a n/a
2 1BQP - MAN C6 H12 O6 C([C@@H]1[....
3 1OFS - SUC C12 H22 O11 C([C@@H]1[....
4 1HKD - GYP C7 H14 O6 CO[C@@H]1[....
5 1LOA - GYP C7 H14 O6 CO[C@@H]1[....
6 1LOC - MDP DAL ZGL n/a n/a
7 1LOB - MMA C7 H14 O6 CO[C@@H]1[....
8 1LOG - MAN BMA NAG n/a n/a
9 1LOD - MUR C9 H17 N O7 C[C@H](C(=....
50% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 1LES - GLC FRU n/a n/a
2 1BQP - MAN C6 H12 O6 C([C@@H]1[....
3 1OFS - SUC C12 H22 O11 C([C@@H]1[....
4 1HKD - GYP C7 H14 O6 CO[C@@H]1[....
5 1LOA - GYP C7 H14 O6 CO[C@@H]1[....
6 1LOC - MDP DAL ZGL n/a n/a
7 1LOB - MMA C7 H14 O6 CO[C@@H]1[....
8 1LOG - MAN BMA NAG n/a n/a
9 1LOD - MUR C9 H17 N O7 C[C@H](C(=....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLC FRU; Similar ligands found: 41
No: Ligand ECFP6 Tc MDL keys Tc
1 TUR 1 1
2 GLC FRU 1 1
3 BTU 1 1
4 GLC BDF 0.583333 0.871795
5 BMA FRU 0.551724 1
6 FRU GAL 0.551724 1
7 TRE 0.520833 0.842105
8 BGC BGC BGC FRU 0.477612 0.973684
9 BQZ 0.462963 0.763158
10 RZM 0.42623 0.777778
11 GLA MBG 0.423729 0.8
12 LAT GLA 0.423729 0.842105
13 2M4 0.423729 0.842105
14 B2G 0.416667 0.842105
15 CBI 0.416667 0.842105
16 LAT 0.416667 0.842105
17 CBK 0.416667 0.842105
18 MAB 0.416667 0.842105
19 N9S 0.416667 0.842105
20 GAL BGC 0.416667 0.842105
21 M3M 0.416667 0.842105
22 LBT 0.416667 0.842105
23 BMA GAL 0.416667 0.842105
24 LB2 0.416667 0.842105
25 GLA GLA 0.416667 0.842105
26 MAL 0.416667 0.842105
27 GLA GAL 0.416667 0.842105
28 BGC BMA 0.416667 0.842105
29 BGC GAL 0.416667 0.842105
30 GLC GAL 0.416667 0.842105
31 MAN GLC 0.416667 0.842105
32 NGR 0.416667 0.842105
33 GLC IFM 0.415385 0.666667
34 MAN IFM 0.415385 0.666667
35 5QP 0.40625 0.794872
36 GAL MBG 0.403226 0.8
37 T6P 0.403226 0.702128
38 M13 0.403226 0.8
39 MDM 0.403226 0.8
40 DR5 0.403226 0.8
41 MMA MAN 0.403226 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LES; Ligand: GLC FRU; Similar sites found with APoc: 226
This union binding pocket(no: 1) in the query (biounit: 1les.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 2NU5 NAG None
2 2GUC MAN None
3 2HYQ MAN MAN None
4 2GUD MAN None
5 2HYR BGC GLC None
6 2NUO BGC None
7 2GUD BMA None
8 2GUE NAG None
9 3LL2 MAN MAN MAN MAN MAN MAN MAN MAN None
10 4FG8 ATP None
11 3HGM ATP None
12 4J5R A1R None
13 3A4T SFG 1.10497
14 3X1Z GNP 1.1976
15 3VPH OXM 1.65746
16 3VPH NAD 1.65746
17 5GM1 SAH 1.65746
18 2JG1 ANP 2.76243
19 1PZG A3D 2.76243
20 5OYH T99 3.31492
21 5EB4 FAD 3.31492
22 1AG9 FMN 3.42857
23 3BY8 MLT 3.52113
24 2DUR MAN MAN 3.84615
25 4I54 1C1 3.84615
26 2ZC0 PMP 3.8674
27 4QTB 38Z 3.8674
28 2VHW NAI 3.8674
29 1RM0 NAI 3.8674
30 4OBW SAM 3.8674
31 5VM6 9EG 4.37956
32 1BW9 NAD 4.41989
33 1WPQ NAD 4.41989
34 3HDY FAD 4.41989
35 1BXG HCI 4.41989
36 1BXG NAD 4.41989
37 3HDY GDU 4.41989
38 3ABI NAD 4.41989
39 1C1D PHE 4.41989
40 5A5W GUO 4.41989
41 1BW9 PPY 4.41989
42 5ZZ6 NAD 4.41989
43 2C6Q IMP 4.41989
44 2JK0 ASP 4.41989
45 1C1X HFA 4.41989
46 4YCA NDP 4.97238
47 1J49 NAD 4.97238
48 1SQF SAM 4.97238
49 6BKA FMN 4.97238
50 2FWP ICR 4.97238
51 9LDB NAD 5.52486
52 9LDT NAD 5.52486
53 4UP3 FAD 5.52486
54 4UP3 NDP 5.52486
55 5YRI GLC GLC 5.76923
56 5YRL GLC GLC 5.76923
57 5YRG BGC GLC 5.76923
58 5YRM BGC GLC 5.76923
59 5YRF GLC GLC 5.76923
60 5YRJ BGC GLC 5.76923
61 6AM8 TRP 5.76923
62 4GLL NAD 5.76923
63 1DQX BMP 5.76923
64 2FLI DX5 5.76923
65 4FBL SPD 5.76923
66 1FFU FAD 5.76923
67 5LD5 NAD 5.76923
68 1WY7 SAH 6.07735
69 1V59 FAD 6.48536
70 2ZXI FAD 6.62983
71 3GF4 FAD 6.62983
72 3GF4 UPG 6.62983
73 1LVL FAD 6.62983
74 4Z87 GDP 6.62983
75 6FA4 GNP 6.93642
76 5WDR GNP 7.01754
77 2NPX NAD 7.18232
78 2NPX FAD 7.18232
79 3ZBQ GDP 7.18232
80 2VAP GDP 7.18232
81 3OA2 NAD 7.18232
82 3TA2 AKG 7.62712
83 1LTH NAD 7.69231
84 5LXT GTP 7.69231
85 1JXZ BCA 7.69231
86 1YJQ NAP 7.69231
87 3RYC GTP 7.69231
88 5JWC FAD 7.69231
89 1F74 NAY 7.69231
90 1NZY BCA 7.69231
91 5Z21 NAI 7.69231
92 3S5W NAP 7.69231
93 4ZRN NAD 7.69231
94 4X6I 3Y1 7.69231
95 4AT0 FAD 7.73481
96 3GDN HBX 7.73481
97 3GDN FAD 7.73481
98 5OC1 FAD 7.73481
99 1FEC FAD 7.73481
100 4IMG NGF 7.73481
101 3CR3 ADP 8.26446
102 6AA8 NAD 8.28729
103 4YNU FAD 8.83978
104 4YNU LGC 8.83978
105 3VY6 BGC BGC 9.21986
106 3R51 MMA 9.375
107 4RPL FAD 9.39227
108 4ZGS NAD 9.61539
109 5KDS A2G THR ALA PRO GLY GLY NAG SIA 9.61539
110 5ODQ FAD 9.61539
111 4HA6 FAD 9.61539
112 2A92 NAI 9.61539
113 5Z20 NAI 9.61539
114 3BF1 ADP 9.61539
115 1LVW TYD 9.61539
116 5BSH PRO 9.94475
117 3LAD FAD 9.94475
118 1LBZ FBP 9.94475
119 3AFN NAP 10.4972
120 2Q0L NAP 10.4972
121 1H5R THM 11.0497
122 1KEV NDP 11.5385
123 4L3L 5FI 11.5385
124 3QVP FAD 11.5385
125 6CI9 NAP 11.5385
126 2O2C G6Q 11.5385
127 4FL3 ANP 11.5385
128 3FVQ ATP 11.5385
129 4R74 F6P 11.5385
130 1FWV SGA MAG FUC 11.5385
131 5JE8 NAD 11.5385
132 6ER9 NAP 11.6022
133 6ER9 FAD 11.6022
134 2HJR APR 11.6022
135 4CZG ADP 11.7816
136 4CZG QH3 11.7816
137 4JBI NDP 12.1547
138 1IIM TTP 12.7072
139 6D5E GNP 13.1737
140 1DLJ NAI 13.2597
141 1DLJ UGA 13.2597
142 4ZNO SUC 13.4615
143 5EIB GTP 13.4615
144 3IES M24 13.4615
145 4YUW 4JU 13.4615
146 4YUW S4M 13.4615
147 2I7C AAT 13.4615
148 2D1S SLU 13.4615
149 1HKU NAD 13.4615
150 2PT9 S4M 13.4615
151 2PT9 2MH 13.4615
152 5ITZ GTP 13.4615
153 3UCL NAP 13.4615
154 5EYP GTP 13.4615
155 5N5S NAP 13.4615
156 4LNU GTP 13.4615
157 1I8T FAD 13.4615
158 1ELI PYC 13.4615
159 1GJW GLC 13.4615
160 2OD9 A1R NCA 14.3646
161 1SZD APR 14.3646
162 1LDN NAD 14.9171
163 5WPJ NDP 14.9171
164 5TQZ GLC 15.3846
165 6F97 FAD 15.3846
166 1LYX PGA 15.3846
167 3I3X U22 15.3846
168 1SOW NAD 15.3846
169 1MV8 NAD 15.3846
170 3CTY FAD 15.3846
171 1RP0 AHZ 15.3846
172 3ACL 3F1 15.3846
173 4I3V NAD 15.3846
174 4HKP TKW 15.3846
175 1MUU NAD 15.3846
176 5ZI9 FLC 15.3846
177 2GAG NAD 15.3846
178 4EHU ANP 15.3846
179 2CXS F6P 15.3846
180 3CB2 GDP 16.0221
181 5F52 ASP 16.5746
182 2IVF MGD 17.1271
183 1OFD AKG 17.1271
184 1OFD FMN 17.1271
185 4Q4K FMN 17.3077
186 5TWB FAD 17.3077
187 5KZD RCJ 17.3077
188 4PLG OXM 17.3077
189 4PLG NAI 17.3077
190 3L4S NAD 17.3077
191 3L4S 3PG 17.3077
192 2V7B BEZ 17.3077
193 1P9B HDA 18.232
194 1I36 NAP 19.2308
195 4FZV SAM 19.2308
196 1NVM NAD 19.2308
197 4MO2 FAD 19.2308
198 3M89 GSP 19.2308
199 4MO2 FDA 19.2308
200 3RNM FAD 21.1538
201 2Z6J FMN 21.1538
202 2F5Z FAD 21.1538
203 5AB7 MLC 21.1538
204 2BTO GTP 23.0769
205 3C6K MTA 23.0769
206 3C6K SPD 23.0769
207 2YVJ NAI 23.0769
208 3ZKI WZV 23.0769
209 5OE4 3UK 23.0769
210 2UYT LRH 25
211 2UYT ADP 25
212 4YRY FAD 25
213 1CER NAD 25
214 1WP4 NDP 25
215 4N02 FNR 25.9669
216 3QV1 NAD 26.9231
217 4Z24 FAD 26.9231
218 3F8K COA 26.9231
219 2BEK ATP 26.9231
220 4C3Y ANB 28.8462
221 3WYF GTP 28.8462
222 4D57 ARG AMP 32.6923
223 5XFH NAG MAN BMA MAN NAG GAL 36.5385
224 1O94 ADP 36.5385
225 3AD8 NAD 38.4615
226 3WGT QSC 42.3077
Pocket No.: 2; Query (leader) PDB : 1LES; Ligand: GLC FRU; Similar sites found with APoc: 83
This union binding pocket(no: 2) in the query (biounit: 1les.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 1GUA GNP 1.1976
2 6D6L FY4 2.35294
3 5L4S 6KX 3.31492
4 5L4S NAP 3.31492
5 5U8U FAD 3.31492
6 6CGD AKN 3.31492
7 6CGD GNP 3.31492
8 3RFV NAI 3.31492
9 3RFV 15L 3.31492
10 1GAD NAD 3.31492
11 2CM4 RCL 3.33333
12 2RHO GDP 3.38462
13 3OID NDP 3.84615
14 5B4T NAD 3.84615
15 5B4T 3HR 3.84615
16 2Y4O DLL 3.8674
17 1RM0 D6P 3.8674
18 2CUL FAD 3.8674
19 3P7N FMN 3.8674
20 1C1X NAD 4.41989
21 1VG8 GNP 4.41989
22 1D4D FAD 4.41989
23 1QO8 FAD 5.76923
24 1N5D NDP 5.76923
25 4TM3 FAD 5.76923
26 4RLQ 3SK 5.76923
27 4DXD 9PC 5.76923
28 5XDT ZI7 5.76923
29 6AMI TRP 5.76923
30 5ESO TDP 6.07735
31 5ESO ISC 6.07735
32 5GVH FMN 6.07735
33 1V59 NAD 6.48536
34 3TKA SAM 6.62983
35 3AB1 FAD 6.62983
36 3ITJ FAD 6.62983
37 2CUN 3PG 7.18232
38 5O98 NAP 7.69231
39 3F8D FAD 7.73481
40 1UAD GNP 8
41 1WPY BTN 8.28729
42 2Y7G AAE 8.28729
43 1RQL VSO 9.61539
44 4E5N NAD 9.61539
45 1Q1R FAD 9.61539
46 1SB8 NAD 9.61539
47 2HQM FAD 9.61539
48 3NT6 FAD 9.61539
49 1GQ2 NAP 11.0497
50 1H5T DAU 11.0497
51 1H5S TMP 11.0497
52 4HDO GNP 11.0497
53 1JQ3 AAT 11.5385
54 5OVL NAP 11.5385
55 3HAZ NAD 11.5385
56 1QAN SAH 11.5385
57 5J7X FAD 11.5385
58 4PKI ATP 12.1547
59 3MN7 ATP 12.7072
60 3U4L ATP 12.7072
61 3SJH ATP 12.963
62 6D5G GNP 13.1737
63 6D56 GNP 13.1737
64 6BVI GNP 13.1737
65 3UCL FAD 13.4615
66 3UCL CYH 13.4615
67 5XVR TRH 13.4615
68 4LNU GDP 13.4615
69 3IWK NAD 13.4615
70 1W5F G2P 13.4615
71 1TZJ A3B 13.4615
72 1P0F NAP 13.4615
73 2UZ1 TPP 16.5746
74 3TDV GDP 17.3077
75 2C5L GTP 19.6581
76 4PLT NAI 21.1538
77 4PLT OXM 21.1538
78 2HMT NAI 21.1538
79 2Z6I FMN 21.1538
80 2Q3O FMN 21.1538
81 2YVJ FAD 23.0769
82 1TB3 FMN 32.6923
83 3WGT FAD 42.3077
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