Receptor
PDB id Resolution Class Description Source Keywords
1LOX 2.4 Å EC: 1.13.11.33 RABBIT RETICULOCYTE 15-LIPOXYGENASE ORYCTOLAGUS CUNICULUS OXIDOREDUCTASE 15LO_DEPOT2
Ref.: THE STRUCTURE OF MAMMALIAN 15-LIPOXYGENASE REVEALS SIMILARITY TO THE LIPASES AND THE DETERMINANTS OF S SPECIFICITY. NAT.STRUCT.BIOL. V. 4 1003 1997
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FE2 A:840;
Part of Protein;
none;
submit data
55.845 Fe [Fe+2...
RS7 A:841;
Valid;
none;
Ki = 3 uM
256.339 C17 H20 O2 CCCCC...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LOX 2.4 Å EC: 1.13.11.33 RABBIT RETICULOCYTE 15-LIPOXYGENASE ORYCTOLAGUS CUNICULUS OXIDOREDUCTASE 15LO_DEPOT2
Ref.: THE STRUCTURE OF MAMMALIAN 15-LIPOXYGENASE REVEALS SIMILARITY TO THE LIPASES AND THE DETERMINANTS OF S SPECIFICITY. NAT.STRUCT.BIOL. V. 4 1003 1997
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2P0M - RS7 C17 H20 O2 CCCCCCC#Cc....
2 1LOX Ki = 3 uM RS7 C17 H20 O2 CCCCCCC#Cc....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2P0M - RS7 C17 H20 O2 CCCCCCC#Cc....
2 1LOX Ki = 3 uM RS7 C17 H20 O2 CCCCCCC#Cc....
3 3RDE - OYP C23 H34 O3 CCCCCCCCCC....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3FG4 - ACD C20 H32 O2 CCCCCC=C/C....
2 4QWT - ACD C20 H32 O2 CCCCCC=C/C....
3 2P0M - RS7 C17 H20 O2 CCCCCCC#Cc....
4 1LOX Ki = 3 uM RS7 C17 H20 O2 CCCCCCC#Cc....
5 3RDE - OYP C23 H34 O3 CCCCCCCCCC....
6 3V99 - ACD C20 H32 O2 CCCCCC=C/C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RS7; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 RS7 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LOX; Ligand: RS7; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1lox.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
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