Receptor
PDB id Resolution Class Description Source Keywords
1LTZ 1.4 Å EC: 1.14.16.1 CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE HAS BOUND IRON (III) A ND OXIDIZED COFACTOR 7,8-DIHYDROBIOPTERIN CHROMOBACTERIUM VIOLACEUM OXIDOREDUCTASE HYDROXYLASE PHENYLALANINE DIHYDROBIOPTERIN BACTERIAL ENZYME
Ref.: STRUCTURAL COMPARISON OF BACTERIAL AND HUMAN IRON-DEPENDENT PHENYLALANINE HYDROXYLASES: SIMILAR FOLD, DIFFERENT STABILITY AND REACTION RATES. J.MOL.BIOL. V. 320 645 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:401;
Invalid;
none;
submit data
35.453 Cl [Cl-]
FE A:400;
Part of Protein;
none;
submit data
55.845 Fe [Fe+3...
HBI A:500;
Valid;
none;
submit data
239.231 C9 H13 N5 O3 C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LTZ 1.4 Å EC: 1.14.16.1 CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE HAS BOUND IRON (III) A ND OXIDIZED COFACTOR 7,8-DIHYDROBIOPTERIN CHROMOBACTERIUM VIOLACEUM OXIDOREDUCTASE HYDROXYLASE PHENYLALANINE DIHYDROBIOPTERIN BACTERIAL ENZYME
Ref.: STRUCTURAL COMPARISON OF BACTERIAL AND HUMAN IRON-DEPENDENT PHENYLALANINE HYDROXYLASES: SIMILAR FOLD, DIFFERENT STABILITY AND REACTION RATES. J.MOL.BIOL. V. 320 645 2002
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1LTZ - HBI C9 H13 N5 O3 C[C@@H]([C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1LTZ - HBI C9 H13 N5 O3 C[C@@H]([C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1LTZ - HBI C9 H13 N5 O3 C[C@@H]([C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: HBI; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 HBI 1 1
2 44W 0.519231 0.816667
3 PH2 0.464286 0.852459
4 ZSP 0.45 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LTZ; Ligand: HBI; Similar sites found: 19
This union binding pocket(no: 1) in the query (biounit: 1ltz.bio1) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3E9I XAH 0.04039 0.40251 2.0202
2 3MKN DNB 0.002687 0.4457 2.3569
3 1NQU RDL 0.04658 0.42958 2.5974
4 4AZW ATP 0.02223 0.40489 2.6936
5 4N49 MGT 0.01108 0.40283 2.6936
6 3N0S ACO 0.04686 0.40918 2.98507
7 3BEO UDP 0.007149 0.42432 3.0303
8 4IJP 1EH 0.02393 0.40324 3.0303
9 3GDN FAD 0.02997 0.42259 3.367
10 3A5Z KAA 0.03737 0.40433 3.66492
11 4USF 6UI 0.02401 0.40789 4.0404
12 2BIF BOG 0.01983 0.40911 5.72391
13 1NP7 FAD 0.003726 0.45618 7.07071
14 4CNG SAH 0.02682 0.40953 8.23529
15 4LH7 NMN 0.01267 0.40313 8.41751
16 2J07 FAD 0.0153 0.44378 9.28571
17 2J07 HDF 0.0153 0.44378 9.28571
18 2CB8 MYA 0.008787 0.41105 16.092
19 2TOH HBI 0.000003635 0.57686 36.3636
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