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Receptor
PDB id Resolution Class Description Source Keywords
1LTZ 1.4 Å EC: 1.14.16.1 CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE HAS BOUND IRON (III) AND OXIDIZED CO8 -DIHYDROBIOPTERIN CHROMOBACTERIUM VIOLACEUM OXIDOREDUCTASE HYDROXYLASE PHENYLALANINE DIHYDROBIOPTERINBACTERIAL ENZYME
Ref.: STRUCTURAL COMPARISON OF BACTERIAL AND HUMAN IRON-D PHENYLALANINE HYDROXYLASES: SIMILAR FOLD, DIFFERENT STABILITY AND REACTION RATES. J.MOL.BIOL. V. 320 645 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:401;
Invalid;
none;
submit data
35.453 Cl [Cl-]
FE A:400;
Part of Protein;
none;
submit data
55.845 Fe [Fe+3...
HBI A:500;
Valid;
none;
submit data
239.231 C9 H13 N5 O3 C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LTZ 1.4 Å EC: 1.14.16.1 CRYSTAL STRUCTURE OF CHROMOBACTERIUM VIOLACEUM PHENYLALANINE HYDROXYLASE, STRUCTURE HAS BOUND IRON (III) AND OXIDIZED CO8 -DIHYDROBIOPTERIN CHROMOBACTERIUM VIOLACEUM OXIDOREDUCTASE HYDROXYLASE PHENYLALANINE DIHYDROBIOPTERINBACTERIAL ENZYME
Ref.: STRUCTURAL COMPARISON OF BACTERIAL AND HUMAN IRON-D PHENYLALANINE HYDROXYLASES: SIMILAR FOLD, DIFFERENT STABILITY AND REACTION RATES. J.MOL.BIOL. V. 320 645 2002
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1LTZ - HBI C9 H13 N5 O3 C[C@@H]([C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1LTZ - HBI C9 H13 N5 O3 C[C@@H]([C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1LTZ - HBI C9 H13 N5 O3 C[C@@H]([C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: HBI; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 HBI 1 1
2 44W 0.519231 0.816667
3 PH2 0.464286 0.852459
4 ZSP 0.45 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LTZ; Ligand: HBI; Similar sites found with APoc: 39
This union binding pocket(no: 1) in the query (biounit: 1ltz.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 1OYB FMN 2.0202
2 3E9I XAH 2.0202
3 3MKN DNB 2.3569
4 4CNE SAH 2.62172
5 4TMC FMN 2.6936
6 4AZW ATP 2.6936
7 4N49 MGT 2.6936
8 4V36 LYN 2.6936
9 3BEO UDP 3.0303
10 5CB3 APR 3.27869
11 3GDN FAD 3.367
12 3A5Z KAA 3.66492
13 5X8I SQZ 3.7037
14 4USF 6UI 4.0404
15 5XVR TRH 4.3771
16 1HBK MYR 4.49438
17 4CDN FAD 4.7138
18 5AE2 FAD 4.7138
19 1EJB INJ 4.7619
20 2BIF BOG 5.72391
21 1N62 FAD 5.90278
22 5ENZ UDP 6.06061
23 5LXT ACP 6.06061
24 2C94 TSF 6.25
25 4ELG 52J 6.62651
26 1NP7 FAD 7.07071
27 3BJU ATP 7.74411
28 4CNG SAH 8.23529
29 4LH7 NMN 8.41751
30 4I6G FAD 8.75421
31 2J07 FAD 9.28571
32 2J07 HDF 9.28571
33 1KJ8 ATP 9.42761
34 1KJ8 GAR 9.42761
35 3REU ATP 12.9252
36 2CB8 MYA 16.092
37 5WXK TYD 22.8571
38 2TOH HBI 36.3636
39 5J6D 6H5 36.3636
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