Receptor
PDB id Resolution Class Description Source Keywords
1N7F 1.8 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF THE SIXTH PDZ DOMAIN OF GRIP1 IN COMPLEX WITH LIPRIN C-TERMINAL PEPTIDE RATTUS NORVEGICUS PDZ GRIP LIPRIN PROTEIN BINDING
Ref.: CRYSTAL STRUCTURE OF GRIP1 PDZ6-PEPTIDE COMPLEX REVEALS THE STRUCTURAL BASIS FOR CLASS II PDZ TARGET RECOGNITION AND PDZ DOMAIN-MEDIATED MULTIMERIZATION J.BIOL.CHEM. V. 278 8501 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA THR VAL ARG THR TYR SER CYS C:1;
D:1;
Valid;
Valid;
none;
none;
submit data
901.033 n/a SCC(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1N7F 1.8 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF THE SIXTH PDZ DOMAIN OF GRIP1 IN COMPLEX WITH LIPRIN C-TERMINAL PEPTIDE RATTUS NORVEGICUS PDZ GRIP LIPRIN PROTEIN BINDING
Ref.: CRYSTAL STRUCTURE OF GRIP1 PDZ6-PEPTIDE COMPLEX REVEALS THE STRUCTURAL BASIS FOR CLASS II PDZ TARGET RECOGNITION AND PDZ DOMAIN-MEDIATED MULTIMERIZATION J.BIOL.CHEM. V. 278 8501 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1N7F - ALA THR VAL ARG THR TYR SER CYS n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1N7F - ALA THR VAL ARG THR TYR SER CYS n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1N7F - ALA THR VAL ARG THR TYR SER CYS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA THR VAL ARG THR TYR SER CYS; Similar ligands found: 129
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA THR VAL ARG THR TYR SER CYS 1 1
2 ALA ARG THR GLU LEU TYR ARG SER LEU 0.661017 0.933333
3 ACE ALA ARG THR GLU VAL TYR NH2 0.567797 0.931035
4 ALA ARG THR MLY GLN THR ALA ARG TYR 0.555556 0.808824
5 GLU THR VAL ARG PHE GLN SER ASP 0.541985 0.913793
6 ALA THR ARG ASN PHE SER GLY 0.540984 0.85
7 SER ARG ILE ARG ILE ARG GLY TYR VAL ARG 0.53125 0.903226
8 LEU TYR LEU VAL CYS GLY GLU ARG VAL 0.511111 0.883333
9 SER SER ARG LYS GLU TYR TYR ALA 0.5 0.806452
10 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.492188 0.786885
11 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.491803 0.868852
12 ALA GLU THR PHE TYR VAL ASP GLY 0.487805 0.733333
13 LEU TYR LEU VAL CYS GLY GLU ARG GLY PHE 0.482517 0.854839
14 GLU VAL TYR GLU SER 0.482456 0.758621
15 GLY ALA ALA ARG ALA GLU VAL TYR LEU ARG 0.482014 0.852459
16 LEU TYR LEU VAL CYS GLY GLU ARG GLY 0.481752 0.883333
17 ALA VAL TYR ASN PHE ALA THR MET 0.480916 0.707692
18 THR LYS ASN TYR LYS GLN THR SER VAL 0.48062 0.819672
19 ALA GLN PHE SER ALA SER ALA SER ARG 0.479339 0.87931
20 SER ARG TYR TRP ALA ILE ARG THR ARG 0.47619 0.808824
21 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.473684 0.758065
22 ALA TYR ARG 0.472222 0.842105
23 SER ASP TYR GLN ARG LEU 0.471074 0.881356
24 ARG GLY TYR VAL TYR GLN GLY LEU 0.469697 0.822581
25 LEU GLU LYS ALA ARG GLY SER THR TYR 0.468966 0.903226
26 SER LEU TYR LEU THR VAL ALA THR LEU 0.467213 0.775862
27 ALA ARG THR MLY GLN 0.465517 0.705882
28 THR LYS ASN TYR LYS GLN PHE SER VAL 0.460938 0.806452
29 GLY VAL TYR ASP GLY ARG GLU HIS THR VAL 0.459459 0.820895
30 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.458647 0.822581
31 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.456522 0.868852
32 GLY GLY ARG LYS LYS TYR LYS LEU 0.456 0.822581
33 GLY GLY LYS LYS LYS TYR ARG LEU 0.456 0.822581
34 GLY GLY LYS LYS ARG TYR LYS LEU 0.456 0.822581
35 ARG HIS ARG MLY VAL LEU ARG ASP TYR 0.455782 0.706667
36 TYR HIS SEP VAL VAL ARG TYR ALA 0.455172 0.739726
37 CYS THR PHE LYS THR LYS THR ASN 0.454545 0.754098
38 ALA ARG THR 4WQ GLN THR ALA ARG LYS SER 0.452174 0.734375
39 SER LEU TYR ASN THR VAL ALA THR LEU 0.449612 0.766667
40 ALA ILE PHE GLN SER SER MET THR LYS 0.448529 0.723077
41 CYS THR GLU LEU LYS LEU SER ASP TYR 0.448529 0.833333
42 SER GLU LEU GLU ILE LYS ARG TYR 0.448529 0.887097
43 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.447552 0.83871
44 ALA ARG THR MLY GLN THR ALA ARG LYS SER 0.447368 0.779661
45 GLN ARG SER THR SEP THR 0.447154 0.753846
46 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.446667 0.753425
47 ALA THR ALA ALA ALA THR GLU ALA TYR 0.445378 0.741379
48 GLU THR PHE TYR VAL ASP GLY 0.44186 0.770492
49 PHE ARG TYR LEU GLY 0.440945 0.822581
50 PHQ LEU VAL ARG TYR 0.440298 0.854839
51 GLU LEU LYS ARG LYS MET ILE TYR MET 0.439716 0.8
52 ALA PTR ARG 0.438596 0.765625
53 ALA ARG THR M3L GLN THR ALA ARG 0.436508 0.7
54 ARG VAL ALA GLN LEU GLU GLN VAL TYR ILE 0.435714 0.85
55 SER LEU TYR ASN VAL VAL ALA THR LEU 0.435115 0.766667
56 SER SER ILE GLU PHE ALA ARG LEU 0.431655 0.866667
57 ALA ARG THR M3L GLN THR ALA ARG LYS SER 0.430894 0.685714
58 ALA ARG THR M3L GLN THR ALA 0.430894 0.685714
59 ALA ARG THR M3L GLN THR ALA 2MR LYS 0.430894 0.685714
60 GLU GLN TYR LYS PHE TYR SER VAL 0.430769 0.790323
61 GLY ALA GLU VAL PHE TYR VAL ASP GLY ALA 0.428571 0.709677
62 GLU LEU ARG ARG LYS MET MET TYR MET 0.428571 0.828125
63 ILE GLY PRO GLY ARG ALA PHE TYR THR ILE 0.428571 0.716216
64 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.427673 0.72973
65 PHE TYR ARG ALA LEU MET 0.426471 0.825397
66 MET CYS LEU ARG MET THR ALA VAL MET 0.425373 0.806452
67 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.424837 0.732394
68 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.424658 0.72973
69 ALA ARG THR ALY GLN THR ALA 0.422764 0.758065
70 LYS ALA VAL TYR ASN PHE ALA THR MET 0.422535 0.742424
71 ALA PRO ALA LEU ARG VAL VAL LYS 0.422414 0.716667
72 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.422222 0.728571
73 ALA ARG THR MLY GLN THR ALA ARG MLY SER 0.421488 0.691176
74 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.421053 0.903226
75 SER SER TYR ARG ARG PRO VAL GLY ILE 0.421053 0.753425
76 LYS GLN THR SER VAL 0.420561 0.724138
77 ALA ARG SER HIS SEP TYR PRO ALA 0.420382 0.683544
78 SER GLU ILE GLU PHE ALA ARG LEU 0.42029 0.85
79 ALA ALA LEU THR ARG ALA 0.420168 0.810345
80 ALA ARG THR MLZ GLN THR ALA ARG LYS 0.419847 0.738462
81 ALA GLU THR PHE 0.419643 0.672414
82 ALA ARG THR MLY GLN THR ALA 0.419355 0.705882
83 ALA ARG THR MLY GLN THR ALA ARG LYS TYR 0.419355 0.705882
84 ARG TYR GLY PHE VAL ALA ASN PHE 0.41844 0.854839
85 ALA ARG THR M3L GLN THR ALA ARG LYS 0.416 0.685714
86 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.415663 0.746667
87 ALA ASN SER ARG TRP GLN THR SER ILE ILE 0.414966 0.791045
88 VAL PRO LEU ARG PRO MET THR TYR 0.414474 0.756757
89 ALA ARG THR M3L GLN THR ALA ALA LYS ALA 0.413534 0.7
90 GLU LEU ASN ARG LYS MET ILE TYR MET 0.413333 0.818182
91 MET CYS LEU ARG NLE THR ALA VAL MET 0.413043 0.793651
92 ALA ARG THR LYS GLN THR ALA ARG LYS SER 0.412698 0.783333
93 LYS ALA VAL TYR ASN LEU ALA THR MET 0.412587 0.765625
94 CYS VAL ASN GLY SER CYS PHE THR VAL 0.411765 0.766667
95 VAL ARG SER ARG ARG CYS LEU ARG LEU 0.411765 0.847458
96 GLU LEU LYS TPO GLU ARG TYR 0.411348 0.794118
97 GLN SER TYR TPO VAL 0.41129 0.753846
98 SER GLN TYR TYR TYR ASN SER LEU 0.41129 0.774194
99 THR LYS CYS VAL PHE MET 0.410853 0.741935
100 ARG HIS ARG MLZ VAL LEU ARG ASP ASN TYR 0.410256 0.75
101 ARG ARG ARG GLU THR GLN VAL 0.410256 0.827586
102 THR PHE LYS LYS THR ASN 0.409836 0.721311
103 ASP ARG VAL TYR ILE HIS PRO PHE 0.409639 0.675325
104 ALA LEU TYR ASN THR ALA ALA ALA LEU 0.409449 0.716667
105 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.409449 0.816667
106 ALA ARG M3L SER THR GLY GLY ALY 0.408759 0.704225
107 ALA ARG MLY SER THR GLY GLY ALY 0.408759 0.724638
108 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.407643 0.774648
109 THR ARG ARG GLU THR GLN LEU 0.406504 0.816667
110 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.406452 0.712329
111 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.405797 0.80303
112 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 0.405405 0.854839
113 ALA ASN SER ARG TRP ALY THR SER ILE ILE 0.405229 0.742857
114 ILE LYS ARG SER MLZ LYS ASN SER LEU ALA 0.405172 0.71875
115 ALA ARG THR MLZ GLN THR ALA ARG LYS TYR 0.404762 0.707692
116 PHE LEU SER TYR LYS 0.404762 0.786885
117 GLY ASN PHE LEU GLN SER ARG 0.404412 0.852459
118 GLU ARG THR ILE PRO ILE THR ARG GLU 0.402878 0.671233
119 ARG PRO MET THR TYR LYS GLY ALA LEU 0.402439 0.723684
120 ARG THR TYR SEP GLY PRO MET ASN LYS VAL 0.402299 0.695122
121 GLU ALA GLN THR ARG LEU 0.401575 0.813559
122 ALA ARG MLZ SER THR GLY GLY ALY 0.40146 0.742424
123 TYR SER THR CYS TYR PHE ILE MET 0.40146 0.71875
124 LEU PRO PHE GLU ARG ALA THR VAL MET 0.401235 0.693333
125 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.4 0.697368
126 THR ASN GLU TYR LYS VAL 0.4 0.75
127 SER SER VAL VAL GLY VAL TRP TYR LEU 0.4 0.701493
128 OSL DLE THR ARG GLU LEU YNM VAL 0.4 0.727273
129 VAL ALA PHE ARG SER 0.4 0.842105
Similar Binding Sites (Proteins are less than 50% similar to leader)
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