Receptor
PDB id Resolution Class Description Source Keywords
1O9U 2.4 Å EC: 2.7.1.37 GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE HOMO SAPIENS TRANSFERASE-TRANSFERASE SUBSTRATE COMPLEX KINASE INSULIN PTRANSFERASE SERINE/THREONINE-PROTEIN KINASE ATP-BINDING FAMILY PHOSPHORYLATION DEVELOPMENTAL PROTEIN ANTI-ONCOGEAPOPTOSIS TRANSFERASE- TRANSFERASE SUBSTRATE COMPLEX
Ref.: STRUCTURAL BASIS FOR RECRUITMENT OF GLYCOGEN SYNTHA 3BETA TO THE AXIN-APC SCAFFOLD COMPLEX EMBO J. V. 22 494 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ADZ A:1386;
 Valid;
 none;
 submit data
149.153 C6 H7 N5 Cn1cn...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1O9U 2.4 Å EC: 2.7.1.37 GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE HOMO SAPIENS TRANSFERASE-TRANSFERASE SUBSTRATE COMPLEX KINASE INSULIN PTRANSFERASE SERINE/THREONINE-PROTEIN KINASE ATP-BINDING FAMILY PHOSPHORYLATION DEVELOPMENTAL PROTEIN ANTI-ONCOGEAPOPTOSIS TRANSFERASE- TRANSFERASE SUBSTRATE COMPLEX
Ref.: STRUCTURAL BASIS FOR RECRUITMENT OF GLYCOGEN SYNTHA 3BETA TO THE AXIN-APC SCAFFOLD COMPLEX EMBO J. V. 22 494 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 1O9U - ADZ C6 H7 N5 Cn1cnc2c1n....
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1O9U - ADZ C6 H7 N5 Cn1cnc2c1n....
2 4NM5 - MET PRO PRO PRO PRO TPO PRO ARG SER n/a n/a
3 4NM0 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
4 4NU1 - AF3 Al F3 F[Al](F)F
5 4NM3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
6 4NM7 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1O9U - ADZ C6 H7 N5 Cn1cnc2c1n....
2 4NM5 - MET PRO PRO PRO PRO TPO PRO ARG SER n/a n/a
3 4NM0 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
4 4NU1 - AF3 Al F3 F[Al](F)F
5 4NM3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
6 4NM7 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ADZ; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 ADZ 1 1
2 ADK 0.6 0.785714
3 2EC 0.478261 0.871795
4 APS 0.431373 0.723404
5 ARP 0.431373 0.723404
6 5AD 0.425926 0.618182
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1O9U; Ligand: ADZ; Similar sites found with APoc: 56
This union binding pocket(no: 1) in the query (biounit: 1o9u.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 6G34 5ID 14.2857
2 3RI1 3RH 19.1693
3 3RI1 3RH 19.1693
4 5UR1 YY9 19.2926
5 5UR1 YY9 19.2926
6 4ASE AV9 21.1429
7 3VHE 42Q 21.1429
8 4AG8 AXI 23.4177
9 5VC5 96M 23.5294
10 4P5Z Q7M 26
11 4E93 GUI 27.7143
12 3PP0 03Q 27.8107
13 5EOB 5QQ 29.7806
14 5MJA 7O3 29.8361
15 6NSP L0P 30.6397
16 5NKB 8ZT 30.719
17 1U5R ATP 31.3218
18 5UPK ANP 31.7919
19 4AT3 LTI 32.107
20 2XVD AS6 32.1192
21 5M06 ADP 32.2464
22 6ES0 BW8 33.3333
23 5TA6 79D 33.4286
24 2J7T 274 33.7748
25 3DAK ANP 33.7931
26 1RE8 BD2 34
27 6GQM F8H 34.7561
28 4G31 0WH 35.4515
29 3FC2 IBI 35.5224
30 3G5D 1N1 35.6643
31 5TO8 7FM 35.8156
32 5XVG 8FX 36.5188
33 2WEL K88 37.3089
34 2Z7R STU 38.0062
35 6HP9 GKB 38.0952
36 6N0P K81 38.0952
37 6N0P K81 38.0952
38 4QMN DB8 38.8889
39 4CLI 5P8 38.8889
40 4TWP AXI 39.1144
41 4TWP AXI 39.1144
42 5DEY 59T 40.7407
43 5DEY 59T 40.7407
44 4WNP 3RJ 41.8118
45 4WNP 3RJ 41.8118
46 3E8N ATP 42.522
47 3E8N VRA 42.522
48 3E8N ATP 42.522
49 3E8N VRA 42.522
50 5Y86 HRM 43.4286
51 3E7O 35F 45.4286
52 3E7O 35F 45.4286
53 3E7O 35F 45.4286
54 3E7O 35F 45.4286
55 6A1G 9OL 47.1429
56 1OUK 084 47.7143
Pocket No.: 2; Query (leader) PDB : 1O9U; Ligand: ADZ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1o9u.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
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